The active form of Helicobacter pylori vacuolating cytotoxin induces decay‐accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa

• Published in: The Journal of pathology Vol. 258; no. 2; pp. 199 - 209
• Main Authors: Kaneko, Kazuyo, Zaitoun, Abed M, Letley, Darren P, Rhead, Joanne L, Torres, Javier, Spendlove, Ian, Atherton, John C, Robinson, Karen
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2022; Wiley Subscription Services, Inc
• Subjects: Antigens, Bacterial - genetics; Antigens, Bacterial - metabolism; Atrophy; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biopsy; CD55; CD55 Antigens - genetics; CD55 Antigens - metabolism; Cytotoxicity; Cytotoxins - metabolism; decay‐accelerating factor; Enzyme-linked immunosorbent assay; Epithelial cells; Gastric cancer; Gastric mucosa; Gastric Mucosa - pathology; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - genetics; Humans; intestinal metaplasia; Intestine; Metaplasia; Metaplasia - pathology; mRNA; Pathology; Patients; RNA, Messenger - metabolism; siRNA; Stomach Neoplasms - pathology; Strains (organisms); vacuolating cytotoxin; virulence factor; Virulence factors; vacuolating cytotoxin; decay-accelerating factor; Helicobacter pylori; gastric cancer; intestinal metaplasia; virulence factor; CD55

High‐level expression of decay‐accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicobacter pylori infection and virulence factors in th...