The active form of Helicobacter pylori vacuolating cytotoxin induces decay‐accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa
High‐level expression of decay‐accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicobacter pylori infection and virulence factors in th...
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Published in | The Journal of pathology Vol. 258; no. 2; pp. 199 - 209 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Chichester, UK
John Wiley & Sons, Ltd
01.10.2022
Wiley Subscription Services, Inc |
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Abstract | High‐level expression of decay‐accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicobacter pylori infection and virulence factors in the induction of CD55 and its association with histological changes of the human gastric mucosa remain incompletely understood. We hypothesised that CD55 would be increased during infection with more virulent strains of H. pylori, and with more marked gastric mucosal pathology. RT‐qPCR and immunohistochemical analyses of gastric biopsy samples from 42 H. pylori‐infected and 42 uninfected patients revealed that CD55 mRNA and protein were significantly higher in the gastric antrum of H. pylori‐infected patients, and this was associated with the presence of IM, but not atrophy, or inflammation. Increased gastric CD55 and IM were both linked with colonisation by vacA i1‐type strains independently of cagA status, and in vitro studies using isogenic mutants of vacA confirmed the ability of VacA to induce CD55 and sCD55 in gastric epithelial cell lines. siRNA experiments to investigate the function of H. pylori‐induced CD55 showed that CD55 knockdown in gastric epithelial cells partially reduced IL‐8 secretion in response to H. pylori, but this was not due to modulation of bacterial adhesion or cytotoxicity. Finally, plasma samples taken from the same patients were analysed for the soluble form of CD55 (sCD55) by ELISA. sCD55 levels were not influenced by IM and did not correlate with gastric CD55 mRNA levels. These results suggest a new link between active vacA i1‐type H. pylori, IM, and CD55, and identify CD55 as a molecule of potential interest in the management of IM as well as GC treatment. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. |
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AbstractList | High‐level expression of decay‐accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicobacter pylori infection and virulence factors in the induction of CD55 and its association with histological changes of the human gastric mucosa remain incompletely understood. We hypothesised that CD55 would be increased during infection with more virulent strains of H. pylori, and with more marked gastric mucosal pathology. RT‐qPCR and immunohistochemical analyses of gastric biopsy samples from 42 H. pylori‐infected and 42 uninfected patients revealed that CD55 mRNA and protein were significantly higher in the gastric antrum of H. pylori‐infected patients, and this was associated with the presence of IM, but not atrophy, or inflammation. Increased gastric CD55 and IM were both linked with colonisation by vacA i1‐type strains independently of cagA status, and in vitro studies using isogenic mutants of vacA confirmed the ability of VacA to induce CD55 and sCD55 in gastric epithelial cell lines. siRNA experiments to investigate the function of H. pylori‐induced CD55 showed that CD55 knockdown in gastric epithelial cells partially reduced IL‐8 secretion in response to H. pylori, but this was not due to modulation of bacterial adhesion or cytotoxicity. Finally, plasma samples taken from the same patients were analysed for the soluble form of CD55 (sCD55) by ELISA. sCD55 levels were not influenced by IM and did not correlate with gastric CD55 mRNA levels. These results suggest a new link between active vacA i1‐type H. pylori, IM, and CD55, and identify CD55 as a molecule of potential interest in the management of IM as well as GC treatment. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. High‐level expression of decay‐accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported. However, the role of Helicobacter pylori infection and virulence factors in the induction of CD55 and its association with histological changes of the human gastric mucosa remain incompletely understood. We hypothesised that CD55 would be increased during infection with more virulent strains of H. pylori , and with more marked gastric mucosal pathology. RT‐qPCR and immunohistochemical analyses of gastric biopsy samples from 42 H. pylori ‐infected and 42 uninfected patients revealed that CD55 mRNA and protein were significantly higher in the gastric antrum of H. pylori ‐infected patients, and this was associated with the presence of IM, but not atrophy, or inflammation. Increased gastric CD55 and IM were both linked with colonisation by vacA i1‐type strains independently of cagA status, and in vitro studies using isogenic mutants of vacA confirmed the ability of VacA to induce CD55 and sCD55 in gastric epithelial cell lines. siRNA experiments to investigate the function of H. pylori ‐induced CD55 showed that CD55 knockdown in gastric epithelial cells partially reduced IL‐8 secretion in response to H. pylori , but this was not due to modulation of bacterial adhesion or cytotoxicity. Finally, plasma samples taken from the same patients were analysed for the soluble form of CD55 (sCD55) by ELISA. sCD55 levels were not influenced by IM and did not correlate with gastric CD55 mRNA levels. These results suggest a new link between active vacA i1‐type H. pylori , IM, and CD55, and identify CD55 as a molecule of potential interest in the management of IM as well as GC treatment. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. |
Author | Zaitoun, Abed M Rhead, Joanne L Letley, Darren P Torres, Javier Kaneko, Kazuyo Robinson, Karen Spendlove, Ian Atherton, John C |
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Cites_doi | 10.1074/jbc.M304071200 10.4049/jimmunol.0900664 10.1084/jem.20040863 10.1097/00000478-199610000-00001 10.1074/jbc.M801144200 10.1111/j.1440-1746.2005.03876.x 10.1146/annurev.iy.07.040189.000343 10.1093/nar/29.9.e45 10.1136/gutjnl-2018-318126 10.1111/j.1398-9995.1994.tb02656.x 10.1053/j.gastro.2004.06.006 10.1093/infdis/jiu154 10.1053/gast.2002.31902 10.1099/jmm.0.001123 10.3892/or.2014.2987 10.1016/S0140-6736(75)90498-5 10.1074/jbc.270.30.17771 10.4049/jimmunol.177.2.1070 10.1128/IAI.00790-19 10.1084/jem.165.3.848 10.1097/MEG.0b013e328364b53e 10.1002/ijc.28003 10.1074/jbc.M100236200 10.1016/j.gie.2009.12.029 10.1007/978-3-030-62658-7_3 10.1136/gutjnl-2013-306253 10.1016/S0006-291X(02)00480-1 10.1097/MOG.0000000000000472 10.1016/S0304-3835(01)00753-4 10.3322/caac.21660 10.1093/jnci/djm120 10.1007/s10120-015-0462-7 10.1053/j.gastro.2019.12.004 10.1177/1753425916681077 10.1046/j.1365-2559.2002.01350.x 10.1046/j.1365-2559.1998.00539.x 10.1371/journal.pgen.1001069 10.1136/gut.42.4.522 10.1074/jbc.M510275200 10.1074/jbc.M308898200 10.1053/j.gastro.2007.06.056 10.1053/j.gastro.2005.09.056 10.1055/a-0859-1883 10.1152/ajpgi.00281.2007 10.1053/j.gastro.2008.03.041 10.3389/fimmu.2020.599647 10.1146/annurev-pathol-032520-024949 10.4110/in.2018.18.e11 10.1111/hel.12544 |
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Keywords | vacuolating cytotoxin decay-accelerating factor Helicobacter pylori gastric cancer intestinal metaplasia virulence factor CD55 |
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References | 2004; 127 2013; 25 2019; 51 2005; 20 2020; 11 2014; 63 2021; 71 2014; 210 2003; 278 1998; 42 2006; 177 2017; 30 2002; 40 2019; 68 2019; 24 2007; 133 1975; 2 2020; 88 2006; 281 2018; 34 2010; 6 1996; 20 2010; 71 1987; 165 2016; 19 2002; 176 2002; 294 1989; 7 2017; 23 2001; 29 2007; 99 1995; 270 2008; 283 2001; 276 2021; 16 2018; 18 2021; 1302 2004; 279 2019; 42 2005; 201 2002; 122 2005; 129 2013; 133 2020; 69 2009; 183 2020; 158 2008; 135 1998; 33 2008; 294 2014; 31 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_17_1 Rokkas T (e_1_2_7_10_1) 2017; 30 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_37_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_46_1 e_1_2_7_48_1 e_1_2_7_27_1 e_1_2_7_29_1 Dho SH (e_1_2_7_52_1) 2019; 42 e_1_2_7_51_1 e_1_2_7_30_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_38_1 |
References_xml | – volume: 122: start-page: 689 year: 2002 end-page: 696 article-title: Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice publication-title: Gastroenterology – volume: 19: start-page: 166 year: 2016 end-page: 175 article-title: eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta‐analysis publication-title: Gastric Cancer – volume: 6: year: 2010 article-title: A global overview of the genetic and functional diversity in the pathogenicity island publication-title: PLoS Genet – volume: 71: start-page: 209 year: 2021 end-page: 249 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J Clin – volume: 270: start-page: 17771 year: 1995 end-page: 17777 article-title: Mosaicism in vacuolating cytotoxin alleles of . Association of specific types with cytotoxin production and peptic ulceration publication-title: J Biol Chem – volume: 68: start-page: 1545 year: 2019 end-page: 1575 article-title: British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma publication-title: Gut – volume: 63: start-page: 1550 year: 2014 end-page: 1559 article-title: CCL20/CCR6‐mediated migration of regulatory T cells to the ‐infected human gastric mucosa publication-title: Gut – volume: 1302: start-page: 25 year: 2021 end-page: 39 article-title: CXCL8 signaling in the tumor microenvironment publication-title: Adv Exp Med Biol – volume: 20: start-page: 1161 year: 1996 end-page: 1181 article-title: Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994 publication-title: Am J Surg Pathol – volume: 23: start-page: 165 year: 2017 end-page: 174 article-title: Inflammatory signaling pathways induced by in primary human gastric epithelial cells publication-title: Innate Immun – volume: 165: start-page: 848 year: 1987 end-page: 864 article-title: Identification of the complement decay‐accelerating factor (DAF) on epithelium and glandular cells and in body fluids publication-title: J Exp Med – volume: 133: start-page: 1023 year: 2013 end-page: 1032 article-title: Utility of subtyping intestinal metaplasia as marker of gastric cancer risk. A review of the evidence publication-title: Int J Cancer – volume: 135: start-page: 91 year: 2008 end-page: 99 article-title: Clinical relevance of and gene polymorphisms publication-title: Gastroenterology – volume: 11: year: 2020 article-title: Regulation of decay accelerating factor primes human germinal center B cells for phagocytosis publication-title: Front Immunol – volume: 71: start-page: 1150 year: 2010 end-page: 1158 article-title: The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis publication-title: Gastrointest Endosc – volume: 18: year: 2018 article-title: Beyond the role of CD55 as a complement component publication-title: Immune Netw – volume: 30: start-page: 414 year: 2017 end-page: 423 article-title: A systematic review and meta‐analysis of the role of eradication in preventing gastric cancer publication-title: Ann Gastroenterol – volume: 34: start-page: 458 year: 2018 end-page: 464 article-title: Guilt by association: intestinal metaplasia does not progress to gastric cancer publication-title: Curr Opin Gastroenterol – volume: 69: start-page: 218 year: 2020 end-page: 227 article-title: Presence of PAI genes and characterization of s, i and m regions in isolated from Alaskans and their association with clinical pathologies publication-title: J Med Microbiol – volume: 183: start-page: 8099 year: 2009 end-page: 8109 article-title: induces MAPK phosphorylation and AP‐1 activation via a NOD1‐dependent mechanism publication-title: J Immunol – volume: 7: start-page: 35 year: 1989 end-page: 58 article-title: Decay‐accelerating factor: biochemistry, molecular biology, and function publication-title: Annu Rev Immunol – volume: 40: start-page: 339 year: 2002 end-page: 347 article-title: Enhanced expression of decay‐accelerating factor and CD59/homologous restriction factor 20 in intestinal metaplasia, gastric adenomas and intestinal‐type gastric carcinomas but not in diffuse‐type carcinomas publication-title: Histopathology – volume: 20: start-page: 1344 year: 2005 end-page: 1351 article-title: eradication decreases the expression of glycosylphosphatidylinositol‐anchored complement regulators, decay‐accelerating factor and homologous restriction factor 20, in human gastric epithelium publication-title: J Gastroenterol Hepatol – volume: 127: start-page: 514 year: 2004 end-page: 523 article-title: Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of publication-title: Gastroenterology – volume: 283: start-page: 23922 year: 2008 end-page: 23930 article-title: Regulation of the cellular receptor decay‐accelerating factor publication-title: J Biol Chem – volume: 210: start-page: 954 year: 2014 end-page: 963 article-title: A role for the vacuolating cytotoxin, VacA, in colonization and ‐induced metaplasia in the stomach publication-title: J Infect Dis – volume: 281: start-page: 13317 year: 2006 end-page: 13323 article-title: The role of decay‐accelerating factor as a receptor for and a mediator of gastric inflammation publication-title: J Biol Chem – volume: 24: year: 2019 article-title: VacA, a distinct toxin exerts diverse functionalities in numerous cells: an overview publication-title: Helicobacter – volume: 29: year: 2001 article-title: A new mathematical model for relative quantification in real‐time RT‐PCR publication-title: Nucleic Acids Res – volume: 294: start-page: 470 year: 2002 end-page: 479 article-title: Conversion of gastric mucosa to intestinal metaplasia in Cdx2‐expressing transgenic mice publication-title: Biochem Biophys Res Commun – volume: 201: start-page: 567 year: 2005 end-page: 577 article-title: The complement inhibitory protein DAF (CD55) suppresses T cell immunity publication-title: J Exp Med – volume: 33: start-page: 554 year: 1998 end-page: 560 article-title: Altered expression of membrane inhibitors of complement in human gastric epithelium during Helicobacter‐associated gastritis publication-title: Histopathology – volume: 25: start-page: 1431 year: 2013 end-page: 1441 article-title: and genotypes and gastric phenotype: a meta‐analysis publication-title: Eur J Gastroenterol Hepatol – volume: 16: start-page: 123 year: 2021 end-page: 144 article-title: The spectrum of ‐mediated diseases publication-title: Annu Rev Pathol – volume: 158: start-page: 745 year: 2020 end-page: 750 article-title: Histologic subtyping of gastric intestinal metaplasia: overview and considerations for clinical practice publication-title: Gastroenterology – volume: 88: year: 2020 article-title: Bacterial energetic requirements for Cag type IV secretion system‐dependent alterations in gastric epithelial cells publication-title: Infect Immun – volume: 2: start-page: 58 year: 1975 end-page: 60 article-title: A model for gastric cancer epidemiology publication-title: Lancet – volume: 129: start-page: 1807 year: 2005 end-page: 1808 article-title: Staging gastritis: an international proposal publication-title: Gastroenterology – volume: 176: start-page: 47 year: 2002 end-page: 55 article-title: Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach publication-title: Cancer Lett – volume: 276: start-page: 21885 year: 2001 end-page: 21894 article-title: Intestinal epithelial cell differentiation involves activation of p38 mitogen‐activated protein kinase that regulates the homeobox transcription factor CDX2 publication-title: J Biol Chem – volume: 42: start-page: 2686 year: 2019 end-page: 2693 article-title: A novel therapeutic anti‐CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells publication-title: Oncol Rep – volume: 294: start-page: G635 year: 2008 end-page: G647 article-title: Differential regulation of ERK1/2 and p38 MAP kinases in VacA‐induced apoptosis of gastric epithelial cells publication-title: Am J Physiol Gastrointest Liver Physiol – volume: 31: start-page: 1059 year: 2014 end-page: 1066 article-title: Ten‐year follow‐up of a prospective trial for the targeted therapy of gastric cancer with the human monoclonal antibody PAT‐SC1 publication-title: Oncol Rep – volume: 177: start-page: 1070 year: 2006 end-page: 1077 article-title: Costimulation via CD55 on human CD4 T cells mediated by CD97 publication-title: J Immunol – volume: 278: start-page: 26734 year: 2003 end-page: 26741 article-title: Determinants of non‐toxicity in the gastric pathogen publication-title: J Biol Chem – volume: 99: start-page: 1328 year: 2007 end-page: 1334 article-title: cytotoxin‐associated genotype and gastric precancerous lesions publication-title: J Natl Cancer Inst – volume: 279: start-page: 7024 year: 2004 end-page: 7028 article-title: VacA activates the p38/activating transcription factor 2‐mediated signal pathway in AZ‐521 cells publication-title: J Biol Chem – volume: 51: start-page: 365 year: 2019 end-page: 388 article-title: Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019 publication-title: Endoscopy – volume: 42: start-page: 522 year: 1998 end-page: 529 article-title: Expression of cell membrane complement regulatory glycoproteins along the normal and diseased human gastrointestinal tract publication-title: Gut – volume: 281: start-page: 11637 year: 2006 end-page: 11648 article-title: Nucleotide‐binding oligomerization domain‐1 and epidermal growth factor receptor: critical regulators of beta‐defensins during infection publication-title: J Biol Chem – volume: 133: start-page: 926 year: 2007 end-page: 936 article-title: A new vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer publication-title: Gastroenterology – volume: 30 start-page: 414 year: 2017 ident: e_1_2_7_10_1 article-title: A systematic review and meta‐analysis of the role of Helicobacter pylori eradication in preventing gastric cancer publication-title: Ann Gastroenterol contributor: fullname: Rokkas T – ident: e_1_2_7_32_1 doi: 10.1074/jbc.M304071200 – volume: 42 start-page: 2686 year: 2019 ident: e_1_2_7_52_1 article-title: A novel therapeutic anti‐CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells publication-title: Oncol Rep contributor: fullname: Dho SH – ident: e_1_2_7_40_1 doi: 10.4049/jimmunol.0900664 – ident: e_1_2_7_24_1 doi: 10.1084/jem.20040863 – ident: e_1_2_7_34_1 doi: 10.1097/00000478-199610000-00001 – ident: e_1_2_7_28_1 doi: 10.1074/jbc.M801144200 – ident: e_1_2_7_38_1 doi: 10.1111/j.1440-1746.2005.03876.x – ident: e_1_2_7_49_1 doi: 10.1146/annurev.iy.07.040189.000343 – ident: e_1_2_7_33_1 doi: 10.1093/nar/29.9.e45 – ident: e_1_2_7_8_1 doi: 10.1136/gutjnl-2018-318126 – ident: e_1_2_7_27_1 doi: 10.1111/j.1398-9995.1994.tb02656.x – ident: e_1_2_7_12_1 doi: 10.1053/j.gastro.2004.06.006 – ident: e_1_2_7_21_1 doi: 10.1093/infdis/jiu154 – ident: e_1_2_7_48_1 doi: 10.1053/gast.2002.31902 – ident: e_1_2_7_14_1 doi: 10.1099/jmm.0.001123 – ident: e_1_2_7_50_1 doi: 10.3892/or.2014.2987 – ident: e_1_2_7_4_1 doi: 10.1016/S0140-6736(75)90498-5 – ident: e_1_2_7_20_1 doi: 10.1074/jbc.270.30.17771 – ident: e_1_2_7_23_1 doi: 10.4049/jimmunol.177.2.1070 – ident: e_1_2_7_11_1 doi: 10.1128/IAI.00790-19 – ident: e_1_2_7_30_1 doi: 10.1084/jem.165.3.848 – ident: e_1_2_7_17_1 doi: 10.1097/MEG.0b013e328364b53e – ident: e_1_2_7_7_1 doi: 10.1002/ijc.28003 – ident: e_1_2_7_45_1 doi: 10.1074/jbc.M100236200 – ident: e_1_2_7_37_1 doi: 10.1016/j.gie.2009.12.029 – ident: e_1_2_7_42_1 doi: 10.1007/978-3-030-62658-7_3 – ident: e_1_2_7_35_1 doi: 10.1136/gutjnl-2013-306253 – ident: e_1_2_7_47_1 doi: 10.1016/S0006-291X(02)00480-1 – ident: e_1_2_7_51_1 doi: 10.1097/MOG.0000000000000472 – ident: e_1_2_7_46_1 doi: 10.1016/S0304-3835(01)00753-4 – ident: e_1_2_7_2_1 doi: 10.3322/caac.21660 – ident: e_1_2_7_15_1 doi: 10.1093/jnci/djm120 – ident: e_1_2_7_9_1 doi: 10.1007/s10120-015-0462-7 – ident: e_1_2_7_5_1 doi: 10.1053/j.gastro.2019.12.004 – ident: e_1_2_7_41_1 doi: 10.1177/1753425916681077 – ident: e_1_2_7_26_1 doi: 10.1046/j.1365-2559.2002.01350.x – ident: e_1_2_7_29_1 doi: 10.1046/j.1365-2559.1998.00539.x – ident: e_1_2_7_13_1 doi: 10.1371/journal.pgen.1001069 – ident: e_1_2_7_25_1 doi: 10.1136/gut.42.4.522 – ident: e_1_2_7_31_1 doi: 10.1074/jbc.M510275200 – ident: e_1_2_7_44_1 doi: 10.1074/jbc.M308898200 – ident: e_1_2_7_19_1 doi: 10.1053/j.gastro.2007.06.056 – ident: e_1_2_7_36_1 doi: 10.1053/j.gastro.2005.09.056 – ident: e_1_2_7_6_1 doi: 10.1055/a-0859-1883 – ident: e_1_2_7_43_1 doi: 10.1152/ajpgi.00281.2007 – ident: e_1_2_7_16_1 doi: 10.1053/j.gastro.2008.03.041 – ident: e_1_2_7_39_1 doi: 10.3389/fimmu.2020.599647 – ident: e_1_2_7_3_1 doi: 10.1146/annurev-pathol-032520-024949 – ident: e_1_2_7_22_1 doi: 10.4110/in.2018.18.e11 – ident: e_1_2_7_18_1 doi: 10.1111/hel.12544 |
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Snippet | High‐level expression of decay‐accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues.... High-level expression of decay-accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues.... |
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SubjectTerms | Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Atrophy Bacterial Proteins - genetics Bacterial Proteins - metabolism Biopsy CD55 CD55 Antigens - genetics CD55 Antigens - metabolism Cytotoxicity Cytotoxins - metabolism decay‐accelerating factor Enzyme-linked immunosorbent assay Epithelial cells Gastric cancer Gastric mucosa Gastric Mucosa - pathology Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - genetics Humans intestinal metaplasia Intestine Metaplasia Metaplasia - pathology mRNA Pathology Patients RNA, Messenger - metabolism siRNA Stomach Neoplasms - pathology Strains (organisms) vacuolating cytotoxin virulence factor Virulence factors |
Title | The active form of Helicobacter pylori vacuolating cytotoxin induces decay‐accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa |
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