Does the accumulated antiepileptic drug load in chronic epilepsy reflect disease severity?

• Published in: Epilepsia (Copenhagen) Vol. 61; no. 12; pp. 2685 - 2695
• Main Authors: Witt, Juri‐Alexander, Nass, Robert D., Baumgartner, Tobias, Wrede, Randi, Elger, Christian E., Surges, Rainer, Helmstaedter, Christoph
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2020
• Subjects: Adolescent; Adult; Aged; Anticonvulsants - administration & dosage; Anticonvulsants - therapeutic use; Antiepileptic agents; antiepileptic drugs; Chronic Disease; Convulsions & seizures; Cross-Sectional Studies; disease severity; drug load; Epilepsy; Epilepsy - drug therapy; Female; Hippocampus; Humans; Lesions; Male; Middle Aged; pharmacotherapy; Retrospective Studies; Sclerosis; Seizures; Severity of Illness Index; Young Adult; epilepsy; antiepileptic drugs; drug load; disease severity; pharmacotherapy

Objective To ascertain factors that are related to the antiepileptic drug load in epilepsy. Methods In this cross‐sectional study, we analyzed a large cohort of conservatively treated patients with epilepsy (n = 1135) and a smaller homogeneous group of presurgical patients with neuropathologically c...