Two‐year outcomes on bone density and fracture incidence in patients with T2DM randomized to bariatric surgery versus intensive medical therapy

Objective To determine the 2‐year outcomes of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial. Methods 54 subjects (BMI: 36 ± 1 kg/m2, age: 48 ± 4 years...

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Published inObesity (Silver Spring, Md.) Vol. 23; no. 12; pp. 2344 - 2348
Main Authors Maghrabi, Adam H., Wolski, Kathy, Abood, Beth, Licata, Angelo, Pothier, Claire, Bhatt, Deepak L., Nissen, Steven, Brethauer, Stacy A., Kirwan, John P., Schauer, Philip R., Kashyap, Sangeeta R.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.12.2015
Subjects
Adult
Bariatric Surgery - statistics & numerical data
Body Composition - physiology
Body mass index
Bone Density
Diabetes
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - surgery
Diabetes Mellitus, Type 2 - therapy
Female
Follow-Up Studies
Fractures
Fractures, Bone - epidemiology
Gastrointestinal surgery
Humans
Hyperglycemia
Hypoglycemic Agents - administration & dosage
Incidence
Male
Metabolism
Middle Aged
Obesity
Osteoporosis
Studies
Treatment Outcome
Vitamin D
Weight control
Online AccessGet full text
ISSN1930-7381
1930-739X
DOI10.1002/oby.21150

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Abstract Objective To determine the 2‐year outcomes of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial. Methods 54 subjects (BMI: 36 ± 1 kg/m2, age: 48 ± 4 years) with type 2 diabetes (T2DM) (HbA1c: 9.7 ± 2%) were randomized to IMT, RYGB, or SG and underwent DXA at baseline and at 1 and 2 years. Results At 2 years, the reduction in BMI was similar after RYGB and SG and was greater than IMT (P < 0.001). Lean mass was reduced by ∼10%, total bone mineral content reduced by ∼8%, and hip BMD reduced by ∼9% in both surgical groups and was significantly greater than IMT despite increases in vitamin D intake in all groups. The change in hip BMD correlated with weight loss (r = 0.84, P < 0.0001) and changes in lean mass (r = 0.74, P < 0.0001) and leptin (r = 0.53, P < 0.0001). Peripheral fractures were self‐reported in RYGB (4/18 patients), SG (2/19 patients), and IMT (4/16 patients). Conclusions Surgically induced weight loss is associated with modest reductions in lean mass, bone mineral content, and BMD, despite calcium and vitamin D supplementation in patients with T2DM. Awareness for bone loss is indicated for patients undergoing bariatric procedures.
AbstractList OBJECTIVETo determine the 2-year outcomes of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial.METHODS54 subjects (BMI: 36 ± 1 kg/m(2) , age: 48 ± 4 years) with type 2 diabetes (T2DM) (HbA1c : 9.7 ± 2%) were randomized to IMT, RYGB, or SG and underwent DXA at baseline and at 1 and 2 years.RESULTSAt 2 years, the reduction in BMI was similar after RYGB and SG and was greater than IMT (P < 0.001). Lean mass was reduced by ∼10%, total bone mineral content reduced by ∼8%, and hip BMD reduced by ∼9% in both surgical groups and was significantly greater than IMT despite increases in vitamin D intake in all groups. The change in hip BMD correlated with weight loss (r = 0.84, P < 0.0001) and changes in lean mass (r = 0.74, P < 0.0001) and leptin (r = 0.53, P < 0.0001). Peripheral fractures were self-reported in RYGB (4/18 patients), SG (2/19 patients), and IMT (4/16 patients).CONCLUSIONSSurgically induced weight loss is associated with modest reductions in lean mass, bone mineral content, and BMD, despite calcium and vitamin D supplementation in patients with T2DM. Awareness for bone loss is indicated for patients undergoing bariatric procedures.
To determine the 2-year outcomes of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial. 54 subjects (BMI: 36 ± 1 kg/m(2) , age: 48 ± 4 years) with type 2 diabetes (T2DM) (HbA1c : 9.7 ± 2%) were randomized to IMT, RYGB, or SG and underwent DXA at baseline and at 1 and 2 years. At 2 years, the reduction in BMI was similar after RYGB and SG and was greater than IMT (P < 0.001). Lean mass was reduced by ∼10%, total bone mineral content reduced by ∼8%, and hip BMD reduced by ∼9% in both surgical groups and was significantly greater than IMT despite increases in vitamin D intake in all groups. The change in hip BMD correlated with weight loss (r = 0.84, P < 0.0001) and changes in lean mass (r = 0.74, P < 0.0001) and leptin (r = 0.53, P < 0.0001). Peripheral fractures were self-reported in RYGB (4/18 patients), SG (2/19 patients), and IMT (4/16 patients). Surgically induced weight loss is associated with modest reductions in lean mass, bone mineral content, and BMD, despite calcium and vitamin D supplementation in patients with T2DM. Awareness for bone loss is indicated for patients undergoing bariatric procedures.
Objective To determine the 2‐year outcomes of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial. Methods 54 subjects (BMI: 36 ± 1 kg/m2, age: 48 ± 4 years) with type 2 diabetes (T2DM) (HbA1c: 9.7 ± 2%) were randomized to IMT, RYGB, or SG and underwent DXA at baseline and at 1 and 2 years. Results At 2 years, the reduction in BMI was similar after RYGB and SG and was greater than IMT (P < 0.001). Lean mass was reduced by ∼10%, total bone mineral content reduced by ∼8%, and hip BMD reduced by ∼9% in both surgical groups and was significantly greater than IMT despite increases in vitamin D intake in all groups. The change in hip BMD correlated with weight loss (r = 0.84, P < 0.0001) and changes in lean mass (r = 0.74, P < 0.0001) and leptin (r = 0.53, P < 0.0001). Peripheral fractures were self‐reported in RYGB (4/18 patients), SG (2/19 patients), and IMT (4/16 patients). Conclusions Surgically induced weight loss is associated with modest reductions in lean mass, bone mineral content, and BMD, despite calcium and vitamin D supplementation in patients with T2DM. Awareness for bone loss is indicated for patients undergoing bariatric procedures.
To determine the 2-year outcomes of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial. 54 subjects (BMI: 36 ± 1 kg/m^sup 2^, age: 48 ± 4 years) with type 2 diabetes (T2DM) (HbA^sub 1c^: 9.7 ± 2%) were randomized to IMT, RYGB, or SG and underwent DXA at baseline and at 1 and 2 years. At 2 years, the reduction in BMI was similar after RYGB and SG and was greater than IMT (P < 0.001). Lean mass was reduced by ~10%, total bone mineral content reduced by ~8%, and hip BMD reduced by ~9% in both surgical groups and was significantly greater than IMT despite increases in vitamin D intake in all groups. The change in hip BMD correlated with weight loss (r = 0.84, P < 0.0001) and changes in lean mass (r = 0.74, P < 0.0001) and leptin (r = 0.53, P < 0.0001). Peripheral fractures were self-reported in RYGB (4/18 patients), SG (2/19 patients), and IMT (4/16 patients). Surgically induced weight loss is associated with modest reductions in lean mass, bone mineral content, and BMD, despite calcium and vitamin D supplementation in patients with T2DM. Awareness for bone loss is indicated for patients undergoing bariatric procedures.
Author Licata, Angelo
Kirwan, John P.
Kashyap, Sangeeta R.
Maghrabi, Adam H.
Wolski, Kathy
Schauer, Philip R.
Nissen, Steven
Abood, Beth
Brethauer, Stacy A.
Pothier, Claire
Bhatt, Deepak L.
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  organization: The Cleveland Clinic
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  givenname: Sangeeta R.
  surname: Kashyap
  fullname: Kashyap, Sangeeta R.
  organization: The Cleveland Clinic
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26193177$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1007/s11695-012-0654-8
10.2337/diacare.24.7.1198
10.1210/jc.2008-0481
10.1111/j.1463-1326.2009.01172.x
10.2337/dc12-1168
10.2337/dc12-1596
10.1007/s11695-012-0687-z
10.1136/bmj.e5085
10.1507/endocrj.EJ11-0063
10.1007/s00198-012-1940-y
10.1097/BOR.0b013e328346f832
10.1002/jbmr.2226
10.1007/BF03351073
10.1038/nrendo.2012.48
10.1007/s11695-008-9638-0
10.1089/met.2009.0012
10.1007/s11695-012-0596-1
10.1056/NEJMoa1200225
10.1097/MED.0b013e328350a6e1
10.1038/oby.2009.28
10.1210/jc.2011-0047
10.1016/j.soard.2010.04.002
10.1210/jc.2012-2394
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2015 The Obesity Society.
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Notes Drs. Kashyap and Maghrabi and the Cleveland Clinic Coordinating Center for Clinical Research had full and independent access to all of the data in the study, and Dr. Kashyap takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Kashyap, Maghrabi, Schauer, Brethauer, Bhatt, Nissen, and Pothier. Acquisition of data: Maghrabi and Kashyap. Analysis and interpretation of data: Maghrabi, Kashyap, Wolski, Schauer, Nissen, Bhatt, Kirwan, and Licata. Drafting of the manuscript: Maghrabi and Kashyap. Statistical analysis: Wolski. Obtained funding: Schauer and Kashyap.
Advisory panel of Medscape, LLC. Board member of Boston VA Research Institute, Society of Chest Pain Centers. Chair of American Heart Association Get with the Guidelines Science Subcommittee. Honoraria from the American College of Cardiology, Duke Clinical Research Institute, Slack Publications, WebMD. Research support from Amarin, AstraZeneca/Bristol‐Meyers Squibb, Eisai, Inc., Ethicon, Medtronic, Sanofi, The Medicines Company.
JPK
This research was supported by a grant from Ethicon Endo‐Surgery, American Diabetes Association, and NIH and conducted with support from the Investigator‐Initiated Study Program of LifeScan Inc. and the Cleveland Clinic. The sponsor participated in discussions regarding study design and protocol development and provided logistical support during the trial. The database, statistical analysis, and monitoring were all performed by the Cleveland Clinic Coordinating Center for Clinical Research. The manuscript was prepared by the corresponding author and modified after consultation with coauthors. The sponsor was permitted to review the manuscript and suggest changes, but the final decision on content and submission was exclusively retained by the academic authors.
Research support from Ethicon EndoSurgery. The other authors declare no conflict of interest.
Disclosure
Funding agencies
SRK
Honoraria from Covidien as a speaker and from Ethicon Endo‐Surgery as a scientific advisory board member, consultant, speaker.
PRS
Research support from Nestle, Inc., and ScottCare.
Consultant for Orexigen Therapeutics, Inc., Vivus, Inc. Unfunded research from PLx Pharma, Takeda.
SAB
Research support from Ethicon EndoSurgery, Bard‐Davol. Educational grants from Stryker Endoscopy, Gore, Baxter, Covidien, Allergan. Honoraria from Ethicon Endo‐Surgery as a scientific advisory board member, consultant, speaker. Consultant/advisory board member for RemedyMD, Stryker Endoscopy, Bard‐Davol, Gore, Barosense, Surgiquest, Carefusion.
SN
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References 2010; 12
2013; 36
2012; 366
2012
2013; 98
2011; 96
2012; 19
2011; 23
2014
2012; ;345
2011; 58
2012; 345
2009; 19
2012; 23
2001; 24
2008; 93
2012; 22
2010; 6
2012; 8
2009; 17
2010; 8
e_1_2_6_10_1
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22271358 - Obes Surg. 2012 Apr;22(4):654-67
22525731 - Nat Rev Endocrinol. 2012 Sep;8(9):544-56
20655033 - Surg Obes Relat Dis. 2010 Jul-Aug;6(4):461-2
23295461 - J Clin Endocrinol Metab. 2013 Feb;98(2):541-9
22692668 - Obes Surg. 2012 Aug;22(8):1287-92
11423502 - Diabetes Care. 2001 Jul;24(7):1198-203
20415694 - Diabetes Obes Metab. 2010 May;12(5):452-4
23200926 - Clin Nutr. 2013 Aug;32(4):550-5
23439632 - Diabetes Care. 2013 Aug;36(8):2175-82
19929598 - Metab Syndr Relat Disord. 2010 Feb;8(1):15-20
21532486 - Curr Opin Rheumatol. 2011 Jul;23(4):396-405
18647809 - J Clin Endocrinol Metab. 2008 Oct;93(10):3735-40
23248194 - Diabetes Care. 2013 May;36(5):1153-8
24677277 - J Bone Miner Res. 2014 Jul;29(7):1507-18
22349964 - Osteoporos Int. 2012 Aug;23(8):2081-92
26524609 - Obesity (Silver Spring). 2015 Dec;23(12):2323
18683014 - Obes Surg. 2009 Jan;19(1):41-6
22555865 - Obes Surg. 2012 Jul;22(7):1068-76
21778223 - J Clin Endocrinol Metab. 2011 Sep;96(9):2703-13
21743287 - Aging Clin Exp Res. 2011 Apr;23(2):84-90
22449319 - N Engl J Med. 2012 Apr 26;366(17):1567-76
22867649 - BMJ. 2012;345:e5085
19319140 - Obesity (Silver Spring). 2009 Apr;17 Suppl 1:S1-70, v
22262002 - Curr Opin Endocrinol Diabetes Obes. 2012 Apr;19(2):128-35
21778617 - Endocr J. 2011;58(8):613-24
References_xml – volume: 366
  start-page: 1567
  year: 2012
  end-page: 1576
  article-title: Bariatric surgery versus intensive medical therapy in obese patients with diabetes
  publication-title: N Engl J Med
– volume: 22
  start-page: 1287
  year: 2012
  end-page: 1292
  article-title: Changes in bone mineral density in women following 1‐year gastric bypass surgery
  publication-title: Obes Surg
– volume: 23
  start-page: 396
  year: 2011
  end-page: 405
  article-title: Obesity, bariatric surgery, and bone
  publication-title: Curr Opin Rheumatol
– volume: 96
  start-page: 2703
  year: 2011
  end-page: 2713
  article-title: Influence of adipokines and ghrelin on bone mineral density and fracture risk: A systematic review and meta‐analysis
  publication-title: J Clin Endocrinol Metab
– volume: 8
  start-page: 544
  year: 2012
  end-page: 556
  article-title: Nutritional deficiencies after bariatric surgery
  publication-title: Nat Rev Endocrinol
– volume: 93
  start-page: 3735
  year: 2008
  end-page: 3740
  article-title: The decline in hip bone density after gastric bypass surgery is associated with extent of weight loss
  publication-title: J Clin Endocrinol Metab
– volume: 19
  start-page: 128
  year: 2012
  end-page: 135
  article-title: Type 2 diabetes and bone fractures
  publication-title: Curr Opin Endocrinol Diabetes Obes
– volume: 8
  start-page: 15
  year: 2010
  end-page: 20
  article-title: Differential loss of fat and lean mass in the morbidly obese after bariatric surgery
  publication-title: Metab Syndr Relat Disord
– volume: 22
  start-page: 654
  year: 2012
  end-page: 667
  article-title: Examining the link between bariatric surgery, bone loss, and osteoporosis: A review of bone density studies
  publication-title: Obes Surg
– volume: 17
  start-page: S1
  year: 2009
  end-page: 70
  article-title: American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery medical guidelines for clinical practice for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient
  publication-title: Obesity (Silver Spring)
– volume: 6
  start-page: 461
  year: 2010
  end-page: 462
  article-title: Bariatric surgery, proton pump inhibitors, and possibility of osteoporosis
  publication-title: Surg Obes Relat Dis
– volume: 22
  start-page: 1068
  year: 2012
  end-page: 1076
  article-title: Bone mineral changes in spine and proximal femur in individual obese women after laparoscopic sleeve gastrectomy: A short‐term study
  publication-title: Obes Surg
– volume: 23
  start-page: 2081
  year: 2012
  end-page: 2092
  article-title: The effects of smoking on bone metabolism
  publication-title: Osteoporos Int
– volume: 98
  start-page: 541
  year: 2013
  end-page: 549
  article-title: Bariatric surgery results in cortical bone loss
  publication-title: J Clin Endocrinol Metab
– volume: 345
  start-page: e5085
  year: 2012
  article-title: Risk of fracture after bariatric surgery in the united kingdom:population based, retrospective cohort study
  publication-title: BMJ
– volume: 24
  start-page: 1198
  year: 2001
  end-page: 1203
  article-title: Diabetes and risk of fracture: The blue mountains eye study
  publication-title: Diabetes Care
– volume: 23
  start-page: 84
  year: 2011
  end-page: 90
  article-title: Osteoporosis and risk of fracture in patients with diabetes: An update
  publication-title: Aging Clin Exp Res
– volume: 36
  start-page: 2175
  year: 2013
  end-page: 2182
  article-title: Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: Analysis of a randomized control trial comparing surgery vs. intensive medical treatment
  publication-title: Diabetes Care
– volume: 19
  start-page: 41
  year: 2009
  end-page: 46
  article-title: Changes in bone mineral density, body composition and adiponectin levels in morbidly obese patients after bariatric surgery
  publication-title: Obes Surg
– start-page: S0261
  year: 2012
  end-page: 5614
  article-title: Protein intake and lean tissue mass retention following bariatric surgery
  publication-title: Clin Nutr
– start-page: 1507
  year: 2014
  end-page: 1518
  article-title: Bone metabolism after bariatric surgery
  publication-title: J Bone Miner Res
– volume: 12
  start-page: 452
  year: 2010
  end-page: 454
  article-title: Bariatric surgery vs. Advanced practice medical management in the treatment of type 2 diabetes mellitus: rationale and design of the surgical therapy and medications potentially eradicate diabetes efficiently trial (STAMPEDE)
  publication-title: Diabetes Obes Metab
– volume: 58
  start-page: 613
  year: 2011
  end-page: 624
  article-title: Bone metabolism and fracture risk in type 2 diabetes mellitus
  publication-title: Endocr J
– volume: ;345
  start-page: e5085
  year: 2012
  article-title: Risk of fracture after bariatric surgery in the United Kingdom: population based, retrospective cohort study
  publication-title: BMJ
– volume: 36
  start-page: 1153
  year: 2013
  end-page: 1158
  article-title: Diabetes and risk of fracture‐related hospitalization
  publication-title: Diabetes Care
– ident: e_1_2_6_17_1
  doi: 10.1007/s11695-012-0654-8
– ident: e_1_2_6_23_1
  doi: 10.2337/diacare.24.7.1198
– ident: e_1_2_6_12_1
  doi: 10.1210/jc.2008-0481
– ident: e_1_2_6_3_1
  doi: 10.1111/j.1463-1326.2009.01172.x
– ident: e_1_2_6_22_1
  doi: 10.2337/dc12-1168
– ident: e_1_2_6_2_1
  doi: 10.2337/dc12-1596
– ident: e_1_2_6_18_1
  doi: 10.1007/s11695-012-0687-z
– start-page: S0261
  year: 2012
  ident: e_1_2_6_11_1
  article-title: Protein intake and lean tissue mass retention following bariatric surgery
  publication-title: Clin Nutr
– ident: e_1_2_6_26_1
  doi: 10.1136/bmj.e5085
– ident: e_1_2_6_8_1
  doi: 10.1507/endocrj.EJ11-0063
– ident: e_1_2_6_20_1
  doi: 10.1007/s00198-012-1940-y
– ident: e_1_2_6_13_1
  doi: 10.1097/BOR.0b013e328346f832
– ident: e_1_2_6_27_1
  doi: 10.1002/jbmr.2226
– ident: e_1_2_6_25_1
  doi: 10.1007/BF03351073
– ident: e_1_2_6_9_1
  doi: 10.1038/nrendo.2012.48
– ident: e_1_2_6_6_1
  doi: 10.1007/s11695-008-9638-0
– ident: e_1_2_6_10_1
  doi: 10.1089/met.2009.0012
– ident: e_1_2_6_7_1
  doi: 10.1136/bmj.e5085
– ident: e_1_2_6_16_1
  doi: 10.1007/s11695-012-0596-1
– ident: e_1_2_6_4_1
  doi: 10.1056/NEJMoa1200225
– ident: e_1_2_6_14_1
  doi: 10.1097/MED.0b013e328350a6e1
– ident: e_1_2_6_24_1
  doi: 10.1097/MED.0b013e328350a6e1
– ident: e_1_2_6_5_1
  doi: 10.1038/oby.2009.28
– ident: e_1_2_6_21_1
  doi: 10.1210/jc.2011-0047
– ident: e_1_2_6_15_1
  doi: 10.1016/j.soard.2010.04.002
– ident: e_1_2_6_19_1
  doi: 10.1210/jc.2012-2394
– reference: 23248194 - Diabetes Care. 2013 May;36(5):1153-8
– reference: 21778617 - Endocr J. 2011;58(8):613-24
– reference: 11423502 - Diabetes Care. 2001 Jul;24(7):1198-203
– reference: 22555865 - Obes Surg. 2012 Jul;22(7):1068-76
– reference: 22867649 - BMJ. 2012;345:e5085
– reference: 19929598 - Metab Syndr Relat Disord. 2010 Feb;8(1):15-20
– reference: 22262002 - Curr Opin Endocrinol Diabetes Obes. 2012 Apr;19(2):128-35
– reference: 23439632 - Diabetes Care. 2013 Aug;36(8):2175-82
– reference: 22349964 - Osteoporos Int. 2012 Aug;23(8):2081-92
– reference: 26524609 - Obesity (Silver Spring). 2015 Dec;23(12):2323
– reference: 18647809 - J Clin Endocrinol Metab. 2008 Oct;93(10):3735-40
– reference: 22525731 - Nat Rev Endocrinol. 2012 Sep;8(9):544-56
– reference: 18683014 - Obes Surg. 2009 Jan;19(1):41-6
– reference: 21778223 - J Clin Endocrinol Metab. 2011 Sep;96(9):2703-13
– reference: 20655033 - Surg Obes Relat Dis. 2010 Jul-Aug;6(4):461-2
– reference: 22692668 - Obes Surg. 2012 Aug;22(8):1287-92
– reference: 22271358 - Obes Surg. 2012 Apr;22(4):654-67
– reference: 21743287 - Aging Clin Exp Res. 2011 Apr;23(2):84-90
– reference: 20415694 - Diabetes Obes Metab. 2010 May;12(5):452-4
– reference: 21532486 - Curr Opin Rheumatol. 2011 Jul;23(4):396-405
– reference: 23295461 - J Clin Endocrinol Metab. 2013 Feb;98(2):541-9
– reference: 22449319 - N Engl J Med. 2012 Apr 26;366(17):1567-76
– reference: 23200926 - Clin Nutr. 2013 Aug;32(4):550-5
– reference: 24677277 - J Bone Miner Res. 2014 Jul;29(7):1507-18
– reference: 19319140 - Obesity (Silver Spring). 2009 Apr;17 Suppl 1:S1-70, v
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Snippet Objective To determine the 2‐year outcomes of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body...
To determine the 2-year outcomes of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total...
OBJECTIVETo determine the 2-year outcomes of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass,...
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SubjectTerms Adult
Bariatric Surgery - statistics & numerical data
Body Composition - physiology
Body mass index
Bone Density
Diabetes
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - surgery
Diabetes Mellitus, Type 2 - therapy
Female
Follow-Up Studies
Fractures
Fractures, Bone - epidemiology
Gastrointestinal surgery
Humans
Hyperglycemia
Hypoglycemic Agents - administration & dosage
Incidence
Male
Metabolism
Middle Aged
Obesity
Osteoporosis
Studies
Treatment Outcome
Vitamin D
Weight control
Title Two‐year outcomes on bone density and fracture incidence in patients with T2DM randomized to bariatric surgery versus intensive medical therapy
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Foby.21150
https://www.ncbi.nlm.nih.gov/pubmed/26193177
https://www.proquest.com/docview/1764883382
https://www.proquest.com/docview/1754086836
Volume 23
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