Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 72; no. 8; pp. 1278 - 1288
• Main Authors: Weber, Alexander E., Jalali, Omid, Limfat, Sean, Shkhyan, Ruzanna, Van Der Horst, Robert, Lee, Siyoung, Lin, Yucheng, Li, Liangliang, Mayer, Erik N., Wang, Liming, Liu, Nancy Q., Petrigliano, Frank A., Lieberman, Jay R., Evseenko, Denis
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2020
• Subjects: Adult; Agonists; Animal models; Animals; Arthritis; Biomedical materials; Cartilage; Cartilage (articular); Cartilage diseases; Cartilage, Articular - drug effects; Cell Culture Techniques; Chondrocytes; Chondrocytes - metabolism; Cyclic AMP response element-binding protein; Cyclic AMP Response Element-Binding Protein - metabolism; Degeneration; Disease Models, Animal; Explants; Female; Hedgehog protein; Hedgehog Proteins - antagonists & inhibitors; Homeostasis; Humans; In vivo methods and tests; Indentation; Injections, Intra-Articular; Joints (anatomy); Knee; Knee Joint - metabolism; Male; Meniscectomy; Middle Aged; Modulation; Narcotics; Opioid Peptides - pharmacology; Opioid receptors (type kappa); Osteoarthritis; Osteoarthritis, Knee - drug therapy; Peptides - pharmacology; Peptides - therapeutic use; Rats; Receptors, Opioid, kappa - agonists; Signal Transduction - drug effects; Signaling; Stiffness; Surgery; Swine

Objective Inhibition of hedgehog (HH) signaling prevents cartilage degeneration and promotes repair in animal models of osteoarthritis (OA). This study, undertaken in OA models and in human OA articular cartilage, was designed to explore whether kappa opioid receptor (KOR) modulation via the inhibit...