Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis - Weber, Alexander E.; Jalali, Omid; Limfat, Sean; Shkhyan, Ruzanna; Van Der Horst, Robert; Lee, Siyoung; Lin, Yucheng; Li, Liangliang; Mayer, Erik N.; Wang, Liming; Liu, Nancy Q.; Petrigliano, Frank A.; et al. (Arthritis & rheumatology (Hoboken, N.J.), 2020)
Keywords: Adult; Agonists; Animal models; Animals; Arthritis; Biomedical materials; Cartilage; Cartilage (articular); Cartilage diseases; Cartilage, Articular - drug effects; Cell Culture Techniques; Chondrocytes; Chondrocytes - metabolism; Cyclic AMP response element-binding protein; Cyclic AMP Response Element-Binding Protein - metabolism; Degeneration; Disease Models, Animal; Explants; Female; Hedgehog protein; Hedgehog Proteins - antagonists & inhibitors; Homeostasis; Humans; In vivo methods and tests; Indentation; Injections, Intra-Articular; Joints (anatomy); Knee; Knee Joint - metabolism; Male; Meniscectomy; Middle Aged; Modulation; Narcotics; Opioid Peptides - pharmacology; Opioid receptors (type kappa); Osteoarthritis; Osteoarthritis, Knee - drug therapy; Peptides - pharmacology; Peptides - therapeutic use; Rats; Receptors, Opioid, kappa - agonists; Signal Transduction - drug effects; Signaling; Stiffness; Surgery; Swine