Multimodal Imaging of Substantia Nigra in Parkinson's Disease with Levodopa‐Induced Dyskinesia

• Published in: Movement disorders Vol. 38; no. 4; pp. 616 - 625
• Main Authors: Su, Dongning, Gan, Yawen, Zhang, Zhe, Cui, Yusha, Zhang, Zhijin, Liu, Zhu, Wang, Zhan, Zhou, Junhong, Sossi, Vesna, Stoessl, A. Jon, Wu, Tao, Jing, Jing, Feng, Tao
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2023; Wiley Subscription Services, Inc
• Subjects: Dyskinesia; Dyskinesias; Functional magnetic resonance imaging; Humans; Image processing; Levodopa; Levodopa - adverse effects; levodopa‐induced dyskinesia; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Mapping; Movement disorders; MRI; multimodal; Multimodal Imaging; Neural networks; Neurodegeneration; Neurodegenerative diseases; Parkinson Disease - diagnostic imaging; Parkinson Disease - drug therapy; Parkinson Disease - pathology; Parkinson's disease; Putamen; Structure-function relationships; Substantia nigra; Substantia Nigra - diagnostic imaging; Substantia Nigra - pathology; levodopa-induced dyskinesia; substantia nigra; multimodal; Parkinson's disease; MRI

Background Degeneration of the substantia nigra (SN) may contribute to levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD), but the exact characteristics of SN in LID remain unclear. Objective To further understand the pathogenesis of patients with PD with LID (PD‐LID), we explored th...