AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression

• Published in: Immunology Vol. 168; no. 4; pp. 654 - 670
• Main Authors: Cheng, He‐Hsiung, Hung‐Ke, Lin, Sheu, Meei‐Ling, Lee, Chun‐Yi, Tsai, Yi‐Ching, Lai, De‐Wei
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2023
• Subjects: 5'-Nucleotidase - genetics; 5'-Nucleotidase - metabolism; Adenosine; aryl hydrocarbon receptor; Autoimmune diseases; Binding sites; CD4 antigen; Cell lines; Chronic conditions; Correlation; Dioxygenases - genetics; Dioxygenases - metabolism; DNA methylation; DNA-Binding Proteins - metabolism; Down-Regulation; Forkhead Transcription Factors - metabolism; Foxp3 protein; Gene expression; GPI-Linked Proteins - genetics; GPI-Linked Proteins - metabolism; Humans; Immunoregulation; Immunosuppressive agents; Interleukin 2 receptors; Lupus; Lupus Erythematosus, Systemic; Lymphocytes; Lymphocytes T; Regulatory mechanisms (biology); Systemic lupus erythematosus; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; ten‐eleven translocation 2; ten-eleven translocation 2; systemic lupus erythematosus; aryl hydrocarbon receptor

The prognosis of systemic lupus erythematosus (SLE) is unpredictable. This study aimed to examine the regulatory mechanism of the AHR/TET2/NT5E pathway during SLE progression. The AHR, TET2 and NT5E expression levels were examined in T regulatory cells (Tregs) of patients with SLE. The correlation o...