Stage‐specific regulation of purine metabolism during infectious growth and sexual reproduction in Fusarium graminearum

Summary Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to play important roles in fungal pathogens but its lifecycle stage‐specific regulation is unclear. By characterizing the genes involved in puri...

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Published inThe New phytologist Vol. 230; no. 2; pp. 757 - 773
Main Authors Sun, Manli, Bian, Zhuyun, Luan, Qiaoqiao, Chen, Yitong, Wang, Wei, Dong, Yongrong, Chen, Lingfeng, Hao, Chaofeng, Xu, Jin‐Rong, Liu, Huiquan
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.04.2021
Subjects
Adenosine
AMP
AMP deaminase
Ascospores
Asexual reproduction
Biosynthesis
Catabolism
Defects
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fungi
Fusarium - metabolism
Fusarium graminearum
Fusarium head blight
Gene Expression Regulation, Fungal
Genes
Growth
infectious growth
Inoculum
Inosine monophosphate
Metabolism
Mutants
Pathogenesis
Plant Diseases
purine de novo pathway
purine salvage pathway
Purines
Reproduction
Reproduction (biology)
Salvaging
Sexual reproduction
Sexual stages
Spores, Fungal - metabolism
pathogenesis
Fusarium graminearum
AMP deaminase
infectious growth
purine de novo pathway
sexual reproduction
purine salvage pathway
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Abstract Summary Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to play important roles in fungal pathogens but its lifecycle stage‐specific regulation is unclear. By characterizing the genes involved in purine de novo and salvage biosynthesis pathways, we showed that de novo syntheses of inosine, adenosine and guanosine monophosphates (IMP, AMP and GMP) are important for vegetative growth, sexual/asexual reproduction, and infectious growth, whereas purine salvage synthesis is dispensable for these stages in F. graminearum. Addition of GMP rescued the defects of the Fgimd1 mutant in vegetative growth and conidiation but not sexual reproduction, whereas addition of AMP rescued all of these defects of the Fgade12 mutant, suggesting that the function of de novo synthesis of GMP rather than AMP is distinct in sexual stages. Moreover, Acd1, an ortholog of AMP deaminase, is dispensable for growth but essential for ascosporogenesis and pathogenesis, suggesting that AMP catabolism has stage‐specific functions during sexual reproduction and infectious growth. The expression of almost all the genes involved in de novo purine synthesis is downregulated during sexual reproduction and infectious growth relative to vegetative growth. This study revealed that F. graminearum has stage‐specific regulation of purine metabolism during infectious growth and sexual reproduction.
AbstractList Summary Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum . Purine metabolism is known to play important roles in fungal pathogens but its lifecycle stage‐specific regulation is unclear. By characterizing the genes involved in purine de novo and salvage biosynthesis pathways, we showed that de novo syntheses of inosine, adenosine and guanosine monophosphates (IMP, AMP and GMP) are important for vegetative growth, sexual/asexual reproduction, and infectious growth, whereas purine salvage synthesis is dispensable for these stages in F. graminearum . Addition of GMP rescued the defects of the Fgimd1 mutant in vegetative growth and conidiation but not sexual reproduction, whereas addition of AMP rescued all of these defects of the Fgade12 mutant, suggesting that the function of de novo synthesis of GMP rather than AMP is distinct in sexual stages. Moreover, Acd1, an ortholog of AMP deaminase, is dispensable for growth but essential for ascosporogenesis and pathogenesis, suggesting that AMP catabolism has stage‐specific functions during sexual reproduction and infectious growth. The expression of almost all the genes involved in de novo purine synthesis is downregulated during sexual reproduction and infectious growth relative to vegetative growth. This study revealed that F. graminearum has stage‐specific regulation of purine metabolism during infectious growth and sexual reproduction.
Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to play important roles in fungal pathogens but its lifecycle stage-specific regulation is unclear. By characterizing the genes involved in purine de novo and salvage biosynthesis pathways, we showed that de novo syntheses of inosine, adenosine and guanosine monophosphates (IMP, AMP and GMP) are important for vegetative growth, sexual/asexual reproduction, and infectious growth, whereas purine salvage synthesis is dispensable for these stages in F. graminearum. Addition of GMP rescued the defects of the Fgimd1 mutant in vegetative growth and conidiation but not sexual reproduction, whereas addition of AMP rescued all of these defects of the Fgade12 mutant, suggesting that the function of de novo synthesis of GMP rather than AMP is distinct in sexual stages. Moreover, Acd1, an ortholog of AMP deaminase, is dispensable for growth but essential for ascosporogenesis and pathogenesis, suggesting that AMP catabolism has stage-specific functions during sexual reproduction and infectious growth. The expression of almost all the genes involved in de novo purine synthesis is downregulated during sexual reproduction and infectious growth relative to vegetative growth. This study revealed that F. graminearum has stage-specific regulation of purine metabolism during infectious growth and sexual reproduction.
Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to play important roles in fungal pathogens but its lifecycle stage‐specific regulation is unclear.By characterizing the genes involved in purine de novo and salvage biosynthesis pathways, we showed that de novo syntheses of inosine, adenosine and guanosine monophosphates (IMP, AMP and GMP) are important for vegetative growth, sexual/asexual reproduction, and infectious growth, whereas purine salvage synthesis is dispensable for these stages in F. graminearum.Addition of GMP rescued the defects of the Fgimd1 mutant in vegetative growth and conidiation but not sexual reproduction, whereas addition of AMP rescued all of these defects of the Fgade12 mutant, suggesting that the function of de novo synthesis of GMP rather than AMP is distinct in sexual stages. Moreover, Acd1, an ortholog of AMP deaminase, is dispensable for growth but essential for ascosporogenesis and pathogenesis, suggesting that AMP catabolism has stage‐specific functions during sexual reproduction and infectious growth. The expression of almost all the genes involved in de novo purine synthesis is downregulated during sexual reproduction and infectious growth relative to vegetative growth.This study revealed that F. graminearum has stage‐specific regulation of purine metabolism during infectious growth and sexual reproduction.
Summary Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to play important roles in fungal pathogens but its lifecycle stage‐specific regulation is unclear. By characterizing the genes involved in purine de novo and salvage biosynthesis pathways, we showed that de novo syntheses of inosine, adenosine and guanosine monophosphates (IMP, AMP and GMP) are important for vegetative growth, sexual/asexual reproduction, and infectious growth, whereas purine salvage synthesis is dispensable for these stages in F. graminearum. Addition of GMP rescued the defects of the Fgimd1 mutant in vegetative growth and conidiation but not sexual reproduction, whereas addition of AMP rescued all of these defects of the Fgade12 mutant, suggesting that the function of de novo synthesis of GMP rather than AMP is distinct in sexual stages. Moreover, Acd1, an ortholog of AMP deaminase, is dispensable for growth but essential for ascosporogenesis and pathogenesis, suggesting that AMP catabolism has stage‐specific functions during sexual reproduction and infectious growth. The expression of almost all the genes involved in de novo purine synthesis is downregulated during sexual reproduction and infectious growth relative to vegetative growth. This study revealed that F. graminearum has stage‐specific regulation of purine metabolism during infectious growth and sexual reproduction.
Author Wang, Wei
Bian, Zhuyun
Luan, Qiaoqiao
Chen, Yitong
Chen, Lingfeng
Sun, Manli
Liu, Huiquan
Hao, Chaofeng
Xu, Jin‐Rong
Dong, Yongrong
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Issue 2
Keywords pathogenesis
Fusarium graminearum
AMP deaminase
infectious growth
purine de novo pathway
sexual reproduction
purine salvage pathway
Language English
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  doi: 10.1146/annurev.phyto.41.011703.115501
– ident: e_1_2_8_27_1
  doi: 10.1038/s41467-020-18240-y
SSID ssj0009562
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Snippet Summary Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to...
Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to play...
Summary Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum . Purine metabolism is known to...
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SubjectTerms Adenosine
AMP
AMP deaminase
Ascospores
Asexual reproduction
Biosynthesis
Catabolism
Defects
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fungi
Fusarium - metabolism
Fusarium graminearum
Fusarium head blight
Gene Expression Regulation, Fungal
Genes
Growth
infectious growth
Inoculum
Inosine monophosphate
Metabolism
Mutants
Pathogenesis
Plant Diseases
purine de novo pathway
purine salvage pathway
Purines
Reproduction
Reproduction (biology)
Salvaging
Sexual reproduction
Sexual stages
Spores, Fungal - metabolism
Title Stage‐specific regulation of purine metabolism during infectious growth and sexual reproduction in Fusarium graminearum
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fnph.17170
https://www.ncbi.nlm.nih.gov/pubmed/33411336
https://www.proquest.com/docview/2501877630
https://search.proquest.com/docview/2476127262
Volume 230
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