Bone Turnover Markers Do Not Predict Fracture Risk in Type 2 Diabetes

• Published in: Journal of bone and mineral research Vol. 35; no. 12; pp. 2363 - 2371
• Main Authors: Napoli, Nicola, Conte, Caterina, Eastell, Richard, Ewing, Susan K, Bauer, Douglas C, Strotmeyer, Elsa S, Black, Dennis M, Samelson, Elizabeth J, Vittinghoff, Eric, Schwartz, Ann V
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.12.2020; Oxford University Press
• Subjects: Aged; Aging; Biomarkers; Body composition; Bone Density; Bone Remodeling; Bone turnover; Cohort Studies; Collagen Type I; CTX‐I PEPTIDE; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Forearm; FRACTURE; Fractures; Fractures, Bone - epidemiology; Humans; OSTEOCALCIN; P1NP PEPTIDE; Peptide Fragments; Peptides; Procollagen; TYPE 2 DIABETES MELLITUS; CTX-I PEPTIDE; FRACTURE; OSTEOCALCIN; P1NP PEPTIDE; TYPE 2 DIABETES MELLITUS

ABSTRACT Type 2 diabetes (T2D) is characterized by increased fracture risk despite higher BMD and reduced bone turnover. BMD underestimates fracture risk in T2D, but the predictive role of bone turnover markers (BTMs) on fracture risk in T2D has not been explored. Thus, we sought to determine whethe...