Interleukin‐10 responses from acute exercise in healthy subjects: A systematic review

• Published in: Journal of cellular physiology Vol. 234; no. 7; pp. 9956 - 9965
• Main Authors: Cabral‐Santos, Carolina, Lima Junior, Edson Alves, Fernandes, Isabela Maia da Cruz, Pinto, Rafael Zambelli, Rosa‐Neto, José César, Bishop, Nicolette Charllote, Lira, Fábio Santos
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2019
• Subjects: acute exercise; Adult; Adults; anti‐inflammatory response; Biomarkers - blood; Clinical trials; Cytokines; Damage assessment; Damage prevention; Exercise - physiology; Female; Humans; Immune response; Immune system; Inflammation; Inflammation - blood; Inflammation - immunology; Inflammation - physiopathology; Inflammation - prevention & control; Interleukin 10; interleukin 10 (IL‐10); Interleukin-10 - blood; Interleukin-10 - immunology; Male; Medical research; Randomized Controlled Trials as Topic; Systematic review; Time Factors; Up-Regulation; Young Adult; acute exercise; inflammation; anti-inflammatory response; interleukin 10 (IL-10)
• DOI: 10.1002/jcp.27920
• ISSN: 0021-9541; 1097-4652

Purpose Interleukin 10 (IL‐10) is a cytokine that plays a critical role with potent anti‐inflammatory properties when produced during exercise, limiting host immune response to pathogens and preventing tissue damage. The purpose of this systematic review was to assess the response of IL‐10 after acute exercise session in healthy adults. Methods Databases of Ovid Medline (1978–2016), CINAHL (1998–2016), EMBASE (2003–2016), SportDiscus (1990–2016), and Web of Science library (1990–2016) were carefully screened. Clinical trials comparing exercise types in healthy individuals were included for pooled analysis. The trials of exercise were methodologically appraised by PEDro Scale. Results Twelve randomized controlled and crossover trials containing 176 individuals were identified for inclusion. The Kruskal‐Wallis test showed no significant differences between type of exercise and the corresponding values in IL‐10 [X2(4) = 2.878; p = 0.449]. The duration of exercise was significantly correlated with increase in IL‐10 changes (Pearson's r = 1.00, 95%CI: 0.015–0.042, p < 0.0001) indicating that 48% of the variation in IL‐10 levels can be explained by the duration of the exercise performed. In addition, despite a linear increase, we did not find a significant correlation with the intensity of exercise and IL‐10 changes (Pearson's r = 0.218, 95%CI: −0.554–0.042, p < 0.035). Conclusion Overall, the duration of the exercise is the single most important factor determining the magnitude of the exercise‐induced increase of plasma IL‐10. Interleukin 10 (IL‐10) is a cytokine that plays a critical role with potent anti‐inflammatory properties when produced during exercise, limiting host immune response to pathogens and preventing tissue damage. Overall, the duration of the exercise is the single most important factor determining the magnitude of the exercise‐induced increase of plasma IL‐10.