Lean non‐alcoholic fatty liver disease patients had comparable total caloric, carbohydrate, protein, fat, iron, sleep duration and overtime work as obese non‐alcoholic fatty liver disease patients

• Published in: Journal of gastroenterology and hepatology Vol. 34; no. 1; pp. 256 - 262
• Main Authors: Li, Chunlong, Guo, Panpan, Okekunle, Akinkunmi Paul, Ji, Xiaoning, Huang, Min, Qi, Jiayue, Jiang, Yongshuai, Feng, Rennan, Li, Rui
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.01.2019
• Subjects: Adult; Case-Control Studies; China; Diet; Dietary Carbohydrates; Dietary Fats; Dietary intake; Dietary Proteins; Energy Intake; Fatty liver; Female; Food; Humans; Iron; Iron, Dietary; lean; Life Style; lifestyle; Lifestyles; Liver diseases; Male; Middle Aged; NAFLD; Non-alcoholic Fatty Liver Disease - complications; Nutrients; obese; Obesity - complications; Overtime; Sleep; Surveys and Questionnaires; Thinness - complications; Time Factors; China; NAFLD; diet; lean; obese; lifestyle
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.14360

Background and Aim Non‐alcoholic fatty liver disease (NAFLD) is a multifactorial disease that involves a complex interaction between genetics, diet, and lifestyle. Although closely related with obese subjects, it is also common in lean humans. This study aimed to characterize the diet and lifestyle of lean and obese NAFLD patients in China. Methods To characterize the diet and lifestyle of lean and obese NAFLD patients, we conducted a matched case–control study that included 351 Chinese adults. General characteristics, dietary intake, and lifestyle were gathered by using a valid and reliable dietary questionnaire. We compared the dietary intake and lifestyle between lean and obese NAFLD patients. Results All NAFLD patients had more total caloric, calorigenic nutrients (carbohydrate, fat, and protein), grain, potato, fruit, and iron with higher levels of waist circumference and overtime work but shorter sleep duration than their corresponding controls. Particularly, lean NAFLD patients consumed comparable total caloric, calorigenic nutrients, iron, sleep duration, and overtime work as obese NAFLD patients, though they consumed lower levels of grain, potato, and fruit (lean NAFLD patients vs. obese NAFLD patients: mean ± SD, g/day grain: 291.8 ± 83.8, 365.2 ± 89.0; potato: 63.5 ± 33.1, 80.4 ± 37.6; fruit: 324.3 ± 148.4, 414.0 ± 220.4; P < 0.0001). Conclusion Non‐alcoholic fatty liver disease patients had higher total caloric, calorigenic nutrients, grain, potato, fruit, iron, and overtime work but shorter sleep duration. Lean NAFLD patients had comparable total caloric, calorigenic nutrients, iron, sleep duration, and overtime work as obese NAFLD patients. These features could be used to the nutritional education and therapeutic guidance for lean NAFLD patients in the future.