Challenges in circulating tumour cell research

Circulating tumour cells (CTCs) are the subject of many published papers, but the diversity of assays used for their analysis can be daunting. This Opinion article discusses issues regarding the detection and characterization of CTCs, and poses the major outstanding questions in this field. During t...

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Published in	Nature reviews. Cancer Vol. 14; no. 9; pp. 623 - 631
Main Authors	Alix-Panabières, Catherine, Pantel, Klaus
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.09.2014 Nature Publishing Group
Subjects	631/67/1857 631/67/322 Biomarkers, Tumor - analysis Biomedicine Blood cells Breast cancer Cancer Research Development and progression Humans Neoplasm Proteins - analysis Neoplastic Cells, Circulating opinion-2 Patient outcomes Physiological aspects Stem cells Tumors United States
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Abstract	Circulating tumour cells (CTCs) are the subject of many published papers, but the diversity of assays used for their analysis can be daunting. This Opinion article discusses issues regarding the detection and characterization of CTCs, and poses the major outstanding questions in this field. During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research.
AbstractList	During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research.During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research. During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research. Circulating tumour cells (CTCs) are the subject of many published papers, but the diversity of assays used for their analysis can be daunting. This Opinion article discusses issues regarding the detection and characterization of CTCs, and poses the major outstanding questions in this field. During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research.
Audience	Academic
Author	Pantel, Klaus Alix-Panabières, Catherine
Author_xml	– sequence: 1 givenname: Catherine surname: Alix-Panabières fullname: Alix-Panabières, Catherine organization: Department of Cellular and Tissular Biopathology of Tumors, University Medical Centre, Saint-Eloi Hospital, Institute of Medicine Regenerative & Biotherapy, Laboratory of Rare Human Circulating Cells, University Institute of Clinical Research UM1 - EA2415 - Epidemiology, Biostatistics & Public Health – sequence: 2 givenname: Klaus surname: Pantel fullname: Pantel, Klaus email: pantel@uke.de organization: Department of Tumor Biology, University Medical Center, Hamburg-Eppendorf
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25154812$$D View this record in MEDLINE/PubMed
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Snippet	Circulating tumour cells (CTCs) are the subject of many published papers, but the diversity of assays used for their analysis can be daunting. This Opinion... During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs...
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SubjectTerms	631/67/1857 631/67/322 Biomarkers, Tumor - analysis Biomedicine Blood cells Breast cancer Cancer Research Development and progression Humans Neoplasm Proteins - analysis Neoplastic Cells, Circulating opinion-2 Patient outcomes Physiological aspects Stem cells Tumors
Title	Challenges in circulating tumour cell research
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