Cross-protection and reassortment studies with avian H2 influenza viruses

• Published in: Archives of virology Vol. 145; no. 6; pp. 1059 - 1066
• Main Authors: Kaverin, N V, Smirnov, Y A, Govorkova, E A, Rudneva, I A, Gitelman, A K, Lipatov, A S, Varich, N L, Yamnikova, S S, Makarova, N V, Webster, R G, Lvov, D K
• Format: Journal Article
• Language: English
• Published: Austria Springer Nature B.V 01.01.2000
• Subjects: Animals; Avian influenza virus; b-Propiolactone; Chick Embryo; Cross Reactions; Immunization; Influenza A virus - genetics; Influenza A virus - immunology; Influenza A virus - pathogenicity; Influenza Vaccines - immunology; Mice; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Reassortant Viruses - genetics; Reassortant Viruses - immunology; Vaccines, Attenuated - immunology

In order to assess the degree of immune cross-protection among avian H2 influenza virus strains, mice were immunised with beta-propiolactone-inactivated virus preparations and infected intranasally with mouse-adapted variant of A/Black Duck/New Jersey/1580/78 (H2N3) strain. The experiments with 11 a...