Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth - Hashizume, Rintaro; Zhang, Ali; Mueller, Sabine; Prados, Michael D.; Lulla, Rishi R.; Goldman, Stewart; Saratsis, Amanda M.; Mazar, Andrew P.; Stegh, Alexander H.; Cheng, Shi-Yuan; Horbinski, Craig; Haas-Kogan, Daphne A.; et al. (Neuro-oncology (Charlottesville, Va.), 2016)
Keywords: Animals; Antineoplastic Agents - therapeutic use; Basic and Translational Investigation; Brain Neoplasms - drug therapy; Brain Neoplasms - enzymology; Brain Neoplasms - radiotherapy; Cell Line, Tumor; Cell Proliferation - drug effects; Chemoradiotherapy - methods; Combined Modality Therapy; Cyclin-Dependent Kinase 4 - antagonists & inhibitors; Cyclin-Dependent Kinase 4 - metabolism; Cyclin-Dependent Kinase 6 - antagonists & inhibitors; Cyclin-Dependent Kinase 6 - metabolism; DNA Damage - drug effects; DNA Repair - drug effects; Female; Glioblastoma - drug therapy; Glioblastoma - enzymology; Glioblastoma - radiotherapy; Heterografts; Humans; Mice, Inbred BALB C; Piperazines - therapeutic use; Pyridines - therapeutic use; Retinoblastoma Protein - metabolism; Rhabdoid Tumor - drug therapy; Rhabdoid Tumor - enzymology; Rhabdoid Tumor - radiotherapy; Survival Analysis; Teratoma - drug therapy; Teratoma - enzymology; Teratoma - radiotherapy; Xenograft Model Antitumor Assays; bioluminescence imaging; atypical teratoid rhabdoid tumor; glioblastoma; xenograft; palbociclib