Carbon disulfide potentiates the effects of impulse noise on the organ of Corti

• Published in: Neurotoxicology (Park Forest South) Vol. 59; pp. 79 - 87
• Main Authors: Carreres Pons, Maria, Chalansonnet, Monique, Venet, Thomas, Thomas, Aurélie, Nunge, Hervé, Merlen, Lise, Cosnier, Frédéric, Llorens, Jordi, Campo, Pierre
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017; Elsevier BV
• Subjects: Acoustic emission; Acoustic emission testing; Acoustic noise; Acoustic Stimulation; Analysis of Variance; Animals; Auditory Threshold - drug effects; Carbon disulfide; Carbon Disulfide - pharmacology; Central nervous system; Combined exposure; Continuous noise; Damage; Disease Models, Animal; Ear; Exposure; Female; Hair cells; Hearing loss; Hearing Loss - etiology; Human exposure; Impulse noise; Microscopy, Electron, Scanning; Middle-ear reflex; Noise; Noise - adverse effects; Noise levels; Occupational health; Organ of Corti; Organ of Corti - drug effects; Organ of Corti - pathology; Organ of Corti - ultrastructure; Otoacoustic Emissions, Spontaneous - drug effects; Otoacoustic Emissions, Spontaneous - physiology; Ototoxicity; Outer hair cells; Pharmacology; Psychoacoustics; Rats; Rats, Long-Evans; Risk assessment; Safety factors; Solvents - adverse effects; Time Factors; Workers; LEX,8 h; Combined exposure; IHC; Rats; CNS; IS; OHC; STEL; SD; Carbon disulfide; FFT; SDH; Risk assessment; Impulse noise; DPOAEs; SEM; dB (A); dB SPL; MER; NIHL; TWA; Middle-ear reflex

•Carbon disulfide exposure has raised concerns for hearing in low-frequency regions.•Despite similar energy, impulse and continuous noises do not have the same traumatic impact on cochlea.•Carbon disulfide potentiates the effects of impulse noise.•Exposure to moderate carbon disulfide concentrations...