Low Circulating 25-Hydroxyvitamin D Concentrations Are Associated with Defects in Insulin Action and Insulin Secretion in Persons with Prediabetes

• Published in: The Journal of nutrition Vol. 145; no. 4; pp. 714 - 719
• Main Authors: Abbasi, Fahim, Blasey, Christine, Feldman, David, Caulfield, Michael P, Hantash, Feras M, Reaven, Gerald M
• Format: Journal Article
• Language: English
• Published: United States American Society for Nutrition 01.04.2015
• Subjects: Blood Glucose - metabolism; Body Mass Index; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - etiology; Female; Humans; Insulin - blood; Insulin - metabolism; Insulin Resistance - physiology; Insulin Secretion; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Male; Middle Aged; Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions; Prediabetic State - blood; Prediabetic State - complications; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; HOMA-IR; HOMA-β; insulin secretion; 25-hydroxyvitamin D; insulin resistance; prediabetes

Individuals with prediabetes mellitus (PreDM) and low circulating 25-hydroxyvitamin D [25(OH)D] are at increased risk of type 2 diabetes mellitus (T2DM). We aimed to determine whether low 25(OH)D concentrations are associated with defects in insulin action and insulin secretion in persons with PreDM...