Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients

• Published in: Breast cancer research and treatment Vol. 103; no. 3; pp. 319 - 329
• Main Authors: Feng, Yumei, Sun, Baocun, Li, Xiaoqing, Zhang, Liang, Niu, Yun, Xiao, Chunhua, Ning, Liansheng, Fang, Zhiyi, Wang, Yuli, Zhang, Lina, Cheng, Jing, Zhang, Wei, Hao, Xishan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.07.2007; Springer Nature B.V
• Subjects: Biological and medical sciences; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Cancer research; Cancer therapies; Clinical outcomes; Cluster Analysis; Disease-Free Survival; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic markers; Gynecology. Andrology. Obstetrics; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphatic Metastasis; Lymphatic system; Mammary gland diseases; Medical sciences; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Prognosis; Risk; Treatment Outcome; Tumors; Human; Prognosis; Malignant lymphadenopathy; Malignant hemopathy; Breast cancer; Malignant tumor; Gene expression; Gene expression profile; Lymph node metastasis; Mammary gland diseases; Lymph node metastases; Primary; Predictive factor

The axillary lymph node status remains the most valuable prognostic factor for breast cancer patients. However, approximately 20-30% of node-positive patients remain free of distant metastases within 15-30 years. It is important to develop molecular markers that are able to predict for the risk of d...