Increased Cerebrospinal Fluid Angiotensin-Converting Enzyme 2 Fragments as a Read-Out of Brain Infection in Patients With COVID-19 Encephalopathy

• Published in: The Journal of infectious diseases Vol. 231; no. 5; pp. e929 - e940
• Main Authors: Lennol, Matthew P, García-Ayllón, María-Salud, Avilés-Granados, Carlos, Trasciatti, Chiara, Tolassi, Chiara, Quaresima, Virginia, Arici, Davide, Cristillo, Viviana, Volonghi, Irene, Caprioli, Francesca, De Giuli, Valeria, Mariotto, Sara, Ferrari, Sergio, Zanusso, Gianluigi, Ashton, Nicholas J, Zetterberg, Henrik, Blennow, Kaj, Padovani, Alessandro, Pilotto, Andrea, Sáez-Valero, Javier
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 02.06.2025
• Subjects: ACE2; Adult; Aged; Angiotensin-Converting Enzyme 2 - cerebrospinal fluid; biomarker; Biomarkers - cerebrospinal fluid; COVID-19; COVID-19 - cerebrospinal fluid; CSF; Emerging diseases; Encephalitis, Viral - cerebrospinal fluid; Female; Human health and pathology; Humans; Infectious diseases; Infectious Medicine; Infektionsmedicin; Life Sciences; Major; Male; Middle Aged; Neurobiology; Neurons and Cognition; SARS-CoV-2; Serine Endopeptidases - cerebrospinal fluid; TMPRSS2; COVID-19; ACE2; TMPRSS2; biomarker; CSF; SARS-CoV-2
• ISSN: 0022-1899; 1537-6613; 1537-6613
• DOI: 10.1093/infdis/jiaf093

This study assesses the cerebrospinal fluid (CSF) levels of the viral receptor angiotensin-converting enzyme 2 (ACE2) and of the serine protease TMPRSS2 fragments in patients with SARS-CoV-2 infection presenting encephalitis (CoV-Enceph). The study included biobanked CSF from 18 CoV-Enceph, 4 subjec...