Age determines the magnitudes of angiotensin II-induced contractions, mRNA, and protein expression of angiotensin type 1 receptors in rat carotid arteries

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 69; no. 5; p. 519
• Main Authors: Vamos, Zoltan, Cseplo, Peter, Ivic, Ivan, Matics, Robert, Hamar, Janos, Koller, Akos
• Format: Journal Article
• Language: English
• Published: United States 01.05.2014
• Subjects: Aging - physiology; Angiotensin II - pharmacology; Animals; Carotid Arteries - drug effects; Carotid Arteries - metabolism; Male; Myography; Rats; Receptor, Angiotensin, Type 1 - drug effects; Receptor, Angiotensin, Type 1 - genetics; Receptor, Angiotensin, Type 1 - metabolism; RNA, Messenger - drug effects; RNA, Messenger - metabolism; Vasoconstriction - drug effects; Vasoconstriction - physiology; Vasoconstrictor Agents - pharmacology; Aging; Senescence; AT1R protein expression; AT1R mRNA expression; Angiotensin II-induced arterial responses

In this study, we hypothesized that aging alters angiotensin II (Ang II)-induced vasomotor responses and expression of vascular mRNA and protein angiotensin type 1 receptor (AT1R). Thus, carotid arteries were isolated from the following age groups of rats: 8 days, 2-9 months, 12-20 months, and 20-30...