The Effect of Residual Osteomyelitis at the Resection Margin in Patients with Surgically Treated Diabetic Foot Infection
Abstract The appropriate antibiotic treatment of surgically resected diabetic foot osteomyelitis is controversial. We conducted a retrospective cohort study to evaluate the prognostic impact of residual osteomyelitis at the surgical margin of surgically resected diabetic foot osteomyelitis, and to a...
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Published in | The Journal of foot and ankle surgery Vol. 50; no. 2; pp. 171 - 175 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier
01.03.2011
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Abstract | Abstract The appropriate antibiotic treatment of surgically resected diabetic foot osteomyelitis is controversial. We conducted a retrospective cohort study to evaluate the prognostic impact of residual osteomyelitis at the surgical margin of surgically resected diabetic foot osteomyelitis, and to assess the effectiveness of postoperative antibiotic therapy for residual osteomyelitis after surgical resection of infected bone. Of the 111 patients included in the study, 39 (35.14%) had pathologically confirmed margins positive for residual osteomyelitis. The median total duration of antibiotic treatment was 19 (range 10–134) days in patients with positive margins, whereas it was 14 (range 2–63) days in those with negative margins ( P = .01). No statistically significant difference ( P = .695) was found in the primary outcome of definite failure, defined as pathologically or microbiologically confirmed infection relapse at the proximal amputation site, between 3 (7.69%) of 39 patients with positive margins and 4 (5.56%) of 47 patients with negative margins. A statistically significant difference ( P = .001) in the secondary outcome, definite treatment failure, or the need for more proximal amputation was found between 17 (43.59%) of 39 patients with positive margins and 11 (15.28%) of 72 patients with negative margins. Residual osteomyelitis at the pathologic margin was associated with a higher rate of treatment failure, despite the longer duration of antibiotic therapy. |
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AbstractList | The appropriate antibiotic treatment of surgically resected diabetic foot osteomyelitis is controversial. We conducted a retrospective cohort study to evaluate the prognostic impact of residual osteomyelitis at the surgical margin of surgically resected diabetic foot osteomyelitis, and to assess the effectiveness of postoperative antibiotic therapy for residual osteomyelitis after surgical resection of infected bone. Of the 111 patients included in the study, 39 (35.14%) had pathologically confirmed margins positive for residual osteomyelitis. The median total duration of antibiotic treatment was 19 (range 10-134) days in patients with positive margins, whereas it was 14 (range 2-63) days in those with negative margins (P = .01). No statistically significant difference (P = .695) was found in the primary outcome of definite failure, defined as pathologically or microbiologically confirmed infection relapse at the proximal amputation site, between 3 (7.69%) of 39 patients with positive margins and 4 (5.56%) of 47 patients with negative margins. A statistically significant difference (P = .001) in the secondary outcome, definite treatment failure, or the need for more proximal amputation was found between 17 (43.59%) of 39 patients with positive margins and 11 (15.28%) of 72 patients with negative margins. Residual osteomyelitis at the pathologic margin was associated with a higher rate of treatment failure, despite the longer duration of antibiotic therapy. Abstract The appropriate antibiotic treatment of surgically resected diabetic foot osteomyelitis is controversial. We conducted a retrospective cohort study to evaluate the prognostic impact of residual osteomyelitis at the surgical margin of surgically resected diabetic foot osteomyelitis, and to assess the effectiveness of postoperative antibiotic therapy for residual osteomyelitis after surgical resection of infected bone. Of the 111 patients included in the study, 39 (35.14%) had pathologically confirmed margins positive for residual osteomyelitis. The median total duration of antibiotic treatment was 19 (range 10–134) days in patients with positive margins, whereas it was 14 (range 2–63) days in those with negative margins ( P = .01). No statistically significant difference ( P = .695) was found in the primary outcome of definite failure, defined as pathologically or microbiologically confirmed infection relapse at the proximal amputation site, between 3 (7.69%) of 39 patients with positive margins and 4 (5.56%) of 47 patients with negative margins. A statistically significant difference ( P = .001) in the secondary outcome, definite treatment failure, or the need for more proximal amputation was found between 17 (43.59%) of 39 patients with positive margins and 11 (15.28%) of 72 patients with negative margins. Residual osteomyelitis at the pathologic margin was associated with a higher rate of treatment failure, despite the longer duration of antibiotic therapy. |
Author | Sorenson, Matthew D., DPM Gundrum, Jacob D., MS Matsuda, Miki, DPM Agger, William A., MD Kowalski, Todd J., MD |
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Keywords | antibiotic 2 treatment failure biopsy bone diabetes foot surgery Endocrinopathy Human Skin disease Nervous system diseases Diabetic Foot Diabetes mellitus Diseases of the osteoarticular system Surgical resection Infection Antibiotic Treatment Biopsy Surgery Orthopedics Osteitis Disease of the foot Bone Antibacterial agent Failure |
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References | Lipsky (10.1053/j.jfas.2010.12.009_bib3) 2004; 39 Jeffcoate (10.1053/j.jfas.2010.12.009_bib4) 2004; 39 Bamberger (10.1053/j.jfas.2010.12.009_bib6) 1987; 83 Simpson (10.1053/j.jfas.2010.12.009_bib5) 2001; 83 Frykberg (10.1053/j.jfas.2010.12.009_bib1) 2006; 45 Brem (10.1053/j.jfas.2010.12.009_bib2) 2006; 117 Senneville (10.1053/j.jfas.2010.12.009_bib7) 2008; 31 Pittet (10.1053/j.jfas.2010.12.009_bib8) 1999; 159 |
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Snippet | Abstract The appropriate antibiotic treatment of surgically resected diabetic foot osteomyelitis is controversial. We conducted a retrospective cohort study to... The appropriate antibiotic treatment of surgically resected diabetic foot osteomyelitis is controversial. We conducted a retrospective cohort study to evaluate... |
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SubjectTerms | Administration, Oral Amputation Anti-Bacterial Agents - therapeutic use Associated diseases and complications Bacterial arthritis and osteitis Bacterial diseases Biological and medical sciences Cohort Studies Diabetes. Impaired glucose tolerance Diabetic Foot - microbiology Diabetic Foot - therapy Diseases of the osteoarticular system Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Human bacterial diseases Humans Infectious diseases Infusions, Parenteral Male Medical sciences Middle Aged Orthopedics Osteomyelitis - microbiology Osteomyelitis - therapy Retrospective Studies Treatment Failure |
Title | The Effect of Residual Osteomyelitis at the Resection Margin in Patients with Surgically Treated Diabetic Foot Infection |
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