Pulmonary vascular effects of bombesin and gastrin-releasing peptide in conscious newborn lambs

• Published in: Journal of applied physiology: respiratory, environmental and exercise physiology Vol. 55; no. 4; p. 1093
• Main Authors: Kulik, T J, Johnson, D E, Elde, R P, Lock, J E
• Format: Journal Article
• Language: English
• Published: United States 01.10.1983
• Subjects: Animals; Animals, Newborn - physiology; Blood Vessels - drug effects; Body Temperature; Bombesin - analysis; Bombesin - pharmacology; Consciousness; Female; Gastrin-Releasing Peptide; Hemodynamics - drug effects; Humans; Infant; Infant, Newborn; Lung - analysis; Male; Peptides - pharmacology; Phenoxybenzamine - pharmacology; Pulmonary Circulation - drug effects; Rats; Rats, Inbred Strains; Sheep - physiology

A growing body of anatomic findings has led investigators to suggest that peptide-containing pulmonary neuroendocrine cells may control pulmonary vascular tone. One such peptide, bombesin, has been found in increased quantities in the lungs of infants with pulmonary disorders that cause pulmonary hy...