Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

• Published in: Brain (London, England : 1878) Vol. 144; no. 8; pp. 2513 - 2526
• Main Authors: O’Callaghan, Claire, Hezemans, Frank H, Ye, Rong, Rua, Catarina, Jones, P Simon, Murley, Alexander G, Holland, Negin, Regenthal, Ralf, Tsvetanov, Kamen A, Wolpe, Noham, Barker, Roger A, Williams-Gray, Caroline H, Robbins, Trevor W, Passamonti, Luca, Rowe, James B
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 04.09.2021
• Subjects: Adrenergic Uptake Inhibitors - pharmacology; Aged; Atomoxetine Hydrochloride - pharmacology; Double-Blind Method; Female; Humans; Inhibition, Psychological; Locus Coeruleus - diagnostic imaging; Locus Coeruleus - drug effects; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Original; Parkinson Disease - diagnostic imaging; Reaction Time - drug effects; noradrenaline; atomoxetine; locus coeruleus; Parkinson’s disease; neuromelanin imaging

Cognitive decline is a common feature of Parkinson’s disease, and many of these cognitive deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory systems represents an important therapeutic strategy. Among these, the locus coeruleus-noradrenaline system has been...