Developing a New Dimension for Fourier Domain Optical Coherence Tomography Images by Simultaneous Measurement of the Refractive Index and Thickness
Fourier domain Optical coherence tomography (OCT) is a widely used high-resolution optical imaging technique. It is useful for various applications in medical imaging, such as ophthalmology (e.g. retinal imaging for diagnosing complications like glaucoma or macular degeneration), dermatology, oncolo...
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Published in | Journal of lasers in medical sciences Vol. 12; no. 1; p. e89 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Iran
Laser Application in Medical Sciences Research Center
29.12.2021
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Abstract | Fourier domain Optical coherence tomography (OCT) is a widely used high-resolution optical imaging technique. It is useful for various applications in medical imaging, such as ophthalmology (e.g. retinal imaging for diagnosing complications like glaucoma or macular degeneration), dermatology, oncology, and cardiology. The ability to noninvasively measure both the refractive index and thickness of biological tissues could have various medical applications and enable earlier disease detection. For example, observing changes in the refractive index can help distinguish between tissues with normal or abnormal function.
In this study, the theoretical framework for simultaneous measurement of the refractive index and physical thickness of multilayer systems is proposed and tested for two different samples, each having three layers, a glass/NaCl solution/glass sample and a glass/sugar solution/glass sample. The whole signal processing procedure and the experimental setup are described.
The refractive index and thickness of salt water and sugar water samples in the Fourier-domain OCT (FD-OCT) system were obtained. The resulting data were compared with reference measurements and showed a deviation of about 1% for the samples.
We tested the proposed framework for the simultaneous extraction of the refractive index and thickness of multilayer systems of salt water and sugar water from its FD-OCT data. We showed that the measured parameters were in agreement with reference amounts. |
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AbstractList | Introduction: Fourier domain Optical coherence tomography (OCT) is a widely used high-resolution optical imaging technique. It is useful for various applications in medical imaging, such as ophthalmology (e.g. retinal imaging for diagnosing complications like glaucoma or macular degeneration), dermatology, oncology, and cardiology. The ability to noninvasively measure both the refractive index and thickness of biological tissues could have various medical applications and enable earlier disease detection. For example, observing changes in the refractive index can help distinguish between tissues with normal or abnormal function. Methods: In this study, the theoretical framework for simultaneous measurement of the refractive index and physical thickness of multilayer systems is proposed and tested for two different samples, each having three layers, a glass/NaCl solution/glass sample and a glass/sugar solution/glass sample. The whole signal processing procedure and the experimental setup are described. Results: The refractive index and thickness of salt water and sugar water samples in the Fourier-domain OCT (FD-OCT) system were obtained. The resulting data were compared with reference measurements and showed a deviation of about 1% for the samples. Conclusion: We tested the proposed framework for the simultaneous extraction of the refractive index and thickness of multilayer systems of salt water and sugar water from its FD-OCT data. We showed that the measured parameters were in agreement with reference amounts. Fourier domain Optical coherence tomography (OCT) is a widely used high-resolution optical imaging technique. It is useful for various applications in medical imaging, such as ophthalmology (e.g. retinal imaging for diagnosing complications like glaucoma or macular degeneration), dermatology, oncology, and cardiology. The ability to noninvasively measure both the refractive index and thickness of biological tissues could have various medical applications and enable earlier disease detection. For example, observing changes in the refractive index can help distinguish between tissues with normal or abnormal function. In this study, the theoretical framework for simultaneous measurement of the refractive index and physical thickness of multilayer systems is proposed and tested for two different samples, each having three layers, a glass/NaCl solution/glass sample and a glass/sugar solution/glass sample. The whole signal processing procedure and the experimental setup are described. The refractive index and thickness of salt water and sugar water samples in the Fourier-domain OCT (FD-OCT) system were obtained. The resulting data were compared with reference measurements and showed a deviation of about 1% for the samples. We tested the proposed framework for the simultaneous extraction of the refractive index and thickness of multilayer systems of salt water and sugar water from its FD-OCT data. We showed that the measured parameters were in agreement with reference amounts. Introduction: Fourier domain Optical coherence tomography (OCT) is a widely used high-resolution optical imaging technique. It is useful for various applications in medical imaging, such as ophthalmology (e.g. retinal imaging for diagnosing complications like glaucoma or macular degeneration), dermatology, oncology, and cardiology. The ability to noninvasively measure both the refractive index and thickness of biological tissues could have various medical applications and enable earlier disease detection. For example, observing changes in the refractive index can help distinguish between tissues with normal or abnormal function. Methods: In this study, the theoretical framework for simultaneous measurement of the refractive index and physical thickness of multilayer systems is proposed and tested for two different samples, each having three layers, a glass/NaCl solution/glass sample and a glass/sugar solution/glass sample. The whole signal processing procedure and the experimental setup are described. Results: The refractive index and thickness of salt water and sugar water samples in the Fourier-domain OCT (FD-OCT) system were obtained. The resulting data were compared with reference measurements and showed a deviation of about 1% for the samples. Conclusion: We tested the proposed framework for the simultaneous extraction of the refractive index and thickness of multilayer systems of salt water and sugar water from its FD-OCT data. We showed that the measured parameters were in agreement with reference amounts. |
Author | Khishkhah, Bahareh Khandani, Salile Amjadi, Ahmad Rajai, Payman Ghodsi, Hamed Razzaghi, Mohammadreza |
AuthorAffiliation | 2 Sharif Applied Physics Research Center, Physics Department, Sharif University of Technology, Tehran, Iran 1 Laser Application in Medical Sciences Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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Keywords | Medical imaging Ophthalmology Optical coherence tomography Fourier domain OCT Refractive index |
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Snippet | Fourier domain Optical coherence tomography (OCT) is a widely used high-resolution optical imaging technique. It is useful for various applications in medical... Introduction: Fourier domain Optical coherence tomography (OCT) is a widely used high-resolution optical imaging technique. It is useful for various... Introduction: Fourier domain Optical coherence tomography (OCT) is a widely used high-resolution optical imaging technique. It is useful for various... |
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Title | Developing a New Dimension for Fourier Domain Optical Coherence Tomography Images by Simultaneous Measurement of the Refractive Index and Thickness |
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