Nuclear Factor E2-Related Factor 2 Mediates Oxidative Stress-Induced Lipid Accumulation in Adipocytes by Increasing Adipogenesis and Decreasing Lipolysis

• Published in: Antioxidants & redox signaling Vol. 32; no. 3; p. 173
• Main Authors: Sun, Xudong, Li, Xiaobing, Jia, Hongdou, Wang, Heyuan, Shui, Guanghou, Qin, Yonglei, Shu, Xin, Wang, Yazhe, Dong, Jihong, Liu, Guowen, Li, Xinwei
• Format: Journal Article
• Language: English
• Published: United States 20.01.2020
• Subjects: Nrf2; SREBP-1; obesity; oxidative stress; PKA

Nuclear factor E2-related factor 2 (Nrf2) is a regulator of cellular oxidative stress and is also involved in lipid metabolism in adipocytes. However, it remains unknown as to whether Nrf2 is the link between oxidative stress and the induction of lipid accumulation in adipocytes. Here, we show that...