Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus
Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. We correlated serial blood transcriptomic profi...
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| Published in | The Journal of infectious diseases Vol. 218; no. 8; pp. 1238 - 1248 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Oxford University Press
08.09.2018
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| Subjects | |
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| Abstract | Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis.
We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis.
We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found.
We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection. |
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| AbstractList | BackgroundAvian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. MethodsWe correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis. ResultsWe found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found. ConclusionsWe developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection. Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis. We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found. We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection. This study correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection with clinical data of patients. Biologically significant transcriptomic profiles associated with blood oxygenation and viral load in the lower respiratory tract were defined. |
| Author | Lee, Horace H Y Li, Yimin Wilson, Ian A Jiang, Wenxin Peiris, Malik Mok, Chris K P Zhong, Nanshan Shen, Lihan Chen, Rongchang Wu, Douglas C Yang, Zifeng Guan, Wenda Wu, Nicholas C |
| AuthorAffiliation | 6 Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 1 State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University 2 Hong Kong University-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong 3 Department of Emergency and Critical Care Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences 5 Department of Integrative Structural and Computational Biology 7 Institute for Cellular and Molecular Biology, University of Texas at Austin 4 Dongguan People’s Hospital, China |
| AuthorAffiliation_xml | – name: 3 Department of Emergency and Critical Care Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences – name: 7 Institute for Cellular and Molecular Biology, University of Texas at Austin – name: 4 Dongguan People’s Hospital, China – name: 5 Department of Integrative Structural and Computational Biology – name: 6 Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California – name: 1 State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University – name: 2 Hong Kong University-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong |
| Author_xml | – sequence: 1 givenname: Wenda surname: Guan fullname: Guan, Wenda organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University – sequence: 2 givenname: Zifeng surname: Yang fullname: Yang, Zifeng organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University – sequence: 3 givenname: Nicholas C surname: Wu fullname: Wu, Nicholas C organization: Department of Integrative Structural and Computational Biology – sequence: 4 givenname: Horace H Y surname: Lee fullname: Lee, Horace H Y organization: Hong Kong University-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong – sequence: 5 givenname: Yimin surname: Li fullname: Li, Yimin organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University – sequence: 6 givenname: Wenxin surname: Jiang fullname: Jiang, Wenxin organization: Department of Emergency and Critical Care Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences – sequence: 7 givenname: Lihan surname: Shen fullname: Shen, Lihan organization: Dongguan People's Hospital, China – sequence: 8 givenname: Douglas C surname: Wu fullname: Wu, Douglas C organization: Institute for Cellular and Molecular Biology, University of Texas at Austin – sequence: 9 givenname: Rongchang surname: Chen fullname: Chen, Rongchang organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University – sequence: 10 givenname: Nanshan surname: Zhong fullname: Zhong, Nanshan organization: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University – sequence: 11 givenname: Ian A surname: Wilson fullname: Wilson, Ian A organization: Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California – sequence: 12 givenname: Malik surname: Peiris fullname: Peiris, Malik organization: Hong Kong University-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong – sequence: 13 givenname: Chris K P surname: Mok fullname: Mok, Chris K P organization: Hong Kong University-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29846612$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/j.1365-2141.1992.tb08237.x 10.1002/gepi.1124 10.1016/j.imlet.2016.08.011 10.1038/nature12379 10.1186/1743-422X-10-253 10.1128/JVI.00570-14 10.1126/science.1239844 10.1371/journal.pone.0162163 10.1183/13993003.02098-2016 10.1086/511159 10.1016/j.meegid.2014.10.016 10.1128/mBio.01331-14 10.1002/jmv.23301 10.3389/fimmu.2017.00550 10.1111/crj.12674 10.4049/jimmunol.1003449 10.1038/ncomms7833 10.1152/ajplung.00311.2013 10.1128/JVI.00851-06 10.1016/j.gene.2014.08.062 10.1038/nature09247 10.1371/journal.ppat.1004869 10.1165/ajrcmb.24.5.4160 10.1111/crj.12346 10.1084/jem.20110226 10.1371/journal.pone.0017186 10.1128/mBio.00362-13 10.1038/nature12392 10.1128/IAI.00832-08 10.1371/journal.pone.0117846 10.1038/nature12391 10.1093/nar/gng015 10.1016/S2213-2600(13)70138-3 10.1056/NEJMoa1304459 10.1371/journal.pmed.1001549 10.1186/gb-2009-10-11-r127 10.1006/smim.2001.0349 10.1093/nar/gku1179 |
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| References | de Wit ( key 20180908093322_CIT0037) 2014; 5 Pankla ( key 20180908093322_CIT0015) 2009; 10 Mandell ( key 20180908093322_CIT0007) 2007; 44 Belser ( key 20180908093322_CIT0021) 2013; 501 Williams ( key 20180908093322_CIT0026) 2014; 306 Baas ( key 20180908093322_CIT0039) 2006; 80 Husain ( key 20180908093322_CIT0005) 2014; 28 World Health Organization ( key 20180908093322_CIT0002) Wang ( key 20180908093322_CIT0011) 2015; 6 Warner ( key 20180908093322_CIT0035) 2001; 24 Mizgerd ( key 20180908093322_CIT0028) 2002; 14 Watanabe ( key 20180908093322_CIT0023) 2013; 501 Craig ( key 20180908093322_CIT0027) 2009; 77 Morrison ( key 20180908093322_CIT0038) 2014; 88 Zhou ( key 20180908093322_CIT0006) 2013; 499 Mejias ( key 20180908093322_CIT0009) 2013; 10 Chan ( key 20180908093322_CIT0004) 2013; 1 World Health Organization ( key 20180908093322_CIT0003) 2016 Goldschmeding ( key 20180908093322_CIT0031) 1992; 81 Gao ( key 20180908093322_CIT0001) 2013; 368 Camp ( key 20180908093322_CIT0025) 2017; 8 Wang ( key 20180908093322_CIT0030) 2016; 11 Parnell ( key 20180908093322_CIT0036) 2011; 6 Mok ( key 20180908093322_CIT0024) 2013; 4 Shi ( key 20180908093322_CIT0019) 2017; 11 Efron ( key 20180908093322_CIT0014) 2002; 23 Brand ( key 20180908093322_CIT0033) 2012; 84 Yang ( key 20180908093322_CIT0012) 2015; 10 Cao ( key 20180908093322_CIT0020) 2018; 12 Irizarry ( key 20180908093322_CIT0013) 2003; 31 Zhu ( key 20180908093322_CIT0022) 2013; 341 Tang ( key 20180908093322_CIT0018) 2017; 49 Zhai ( key 20180908093322_CIT0008) 2015; 11 Xu ( key 20180908093322_CIT0029) 2013; 10 Gene Ontology Consortium ( key 20180908093322_CIT0016) 2015; 43 Hong ( key 20180908093322_CIT0034) 2011; 186 Tu ( key 20180908093322_CIT0040) 2011; 208 Berry ( key 20180908093322_CIT0017) 2010; 466 Mei ( key 20180908093322_CIT0010) 2014; 551 Demaret ( key 20180908093322_CIT0032) 2016; 178 |
| References_xml | – volume: 81 start-page: 336 year: 1992 ident: key 20180908093322_CIT0031 article-title: Further characterization of the NB 1 antigen as a variably expressed 56-62 kD GPI-linked glycoprotein of plasma membranes and specific granules of neutrophils publication-title: Br J Haematol doi: 10.1111/j.1365-2141.1992.tb08237.x contributor: fullname: Goldschmeding – volume: 23 start-page: 70 year: 2002 ident: key 20180908093322_CIT0014 article-title: Empirical Bayes methods and false discovery rates for microarrays publication-title: Genet Epidemiol doi: 10.1002/gepi.1124 contributor: fullname: Efron – volume: 178 start-page: 122 year: 2016 ident: key 20180908093322_CIT0032 article-title: Identification of CD177 as the most dysregulated parameter in a microarray study of purified neutrophils from septic shock patients publication-title: Immunol Lett doi: 10.1016/j.imlet.2016.08.011 contributor: fullname: Demaret – volume: 499 start-page: 500 year: 2013 ident: key 20180908093322_CIT0006 article-title: Biological features of novel avian influenza A (H7N9) virus publication-title: Nature doi: 10.1038/nature12379 contributor: fullname: Zhou – volume: 10 start-page: 253 year: 2013 ident: key 20180908093322_CIT0029 article-title: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus publication-title: Virol J doi: 10.1186/1743-422X-10-253 contributor: fullname: Xu – volume: 88 start-page: 10556 year: 2014 ident: key 20180908093322_CIT0038 article-title: H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice publication-title: J Virol doi: 10.1128/JVI.00570-14 contributor: fullname: Morrison – volume-title: Disease outbreak news. Human infection with avian influenza A(H7N9) virus-China ident: key 20180908093322_CIT0002 contributor: fullname: World Health Organization – volume: 341 start-page: 183 year: 2013 ident: key 20180908093322_CIT0022 article-title: Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs publication-title: Science doi: 10.1126/science.1239844 contributor: fullname: Zhu – volume: 11 start-page: e0162163 year: 2016 ident: key 20180908093322_CIT0030 article-title: PB2-Q591K mutation determines the pathogenicity of avian H9N2 influenza viruses for mammalian species publication-title: PLoS One doi: 10.1371/journal.pone.0162163 contributor: fullname: Wang – volume: 49 start-page: 1602098 year: 2017 ident: key 20180908093322_CIT0018 article-title: A novel immune biomarker IFI27 discriminates between influenza and bacteria in patients with suspected respiratory infection publication-title: Eur Respir J doi: 10.1183/13993003.02098-2016 contributor: fullname: Tang – volume: 44 start-page: S27 year: 2007 ident: key 20180908093322_CIT0007 article-title: Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults publication-title: Clin Infect Dis doi: 10.1086/511159 contributor: fullname: Mandell – volume-title: Influenza monthly risk assessment summary year: 2016 ident: key 20180908093322_CIT0003 contributor: fullname: World Health Organization – volume: 28 start-page: 304 year: 2014 ident: key 20180908093322_CIT0005 article-title: Avian influenza A (H7N9) virus infection in humans: epidemiology, evolution, and pathogenesis publication-title: Infect Genet Evol doi: 10.1016/j.meegid.2014.10.016 contributor: fullname: Husain – volume: 5 start-page: e01331 year: 2014 ident: key 20180908093322_CIT0037 article-title: Influenza virus A/Anhui/1/2013 (H7N9) replicates efficiently in the upper and lower respiratory tracts of cynomolgus macaques publication-title: mBio doi: 10.1128/mBio.01331-14 contributor: fullname: de Wit – volume: 84 start-page: 1471 year: 2012 ident: key 20180908093322_CIT0033 article-title: Use of MMP-8 and MMP-9 to assess disease severity in children with viral lower respiratory tract infections publication-title: J Med Virol doi: 10.1002/jmv.23301 contributor: fullname: Brand – volume: 8 start-page: 550 year: 2017 ident: key 20180908093322_CIT0025 article-title: A role for neutrophils in viral respiratory disease publication-title: Front Immunol doi: 10.3389/fimmu.2017.00550 contributor: fullname: Camp – volume: 12 start-page: 1320 year: 2018 ident: key 20180908093322_CIT0020 article-title: Diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association publication-title: Clin Respir J doi: 10.1111/crj.12674 contributor: fullname: Cao – volume: 186 start-page: 6427 year: 2011 ident: key 20180908093322_CIT0034 article-title: Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae publication-title: J Immunol doi: 10.4049/jimmunol.1003449 contributor: fullname: Hong – volume: 6 start-page: 6833 year: 2015 ident: key 20180908093322_CIT0011 article-title: Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells publication-title: Nat Commun doi: 10.1038/ncomms7833 contributor: fullname: Wang – volume: 306 start-page: L217 year: 2014 ident: key 20180908093322_CIT0026 article-title: The mercurial nature of neutrophils: still an enigma in ARDS publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00311.2013 contributor: fullname: Williams – volume: 80 start-page: 10813 year: 2006 ident: key 20180908093322_CIT0039 article-title: Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics publication-title: J Virol doi: 10.1128/JVI.00851-06 contributor: fullname: Baas – volume: 551 start-page: 255 year: 2014 ident: key 20180908093322_CIT0010 article-title: Global gene expression changes in human peripheral blood after H7N9 infection publication-title: Gene doi: 10.1016/j.gene.2014.08.062 contributor: fullname: Mei – volume: 466 start-page: 973 year: 2010 ident: key 20180908093322_CIT0017 article-title: An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis publication-title: Nature doi: 10.1038/nature09247 contributor: fullname: Berry – volume: 11 start-page: e1004869 year: 2015 ident: key 20180908093322_CIT0008 article-title: Host transcriptional response to influenza and other acute respiratory viral infections–a prospective cohort study publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1004869 contributor: fullname: Zhai – volume: 24 start-page: 537 year: 2001 ident: key 20180908093322_CIT0035 article-title: Role of stromelysin 1 and gelatinase B in experimental acute lung injury publication-title: Am J Respir Cell Mol Biol doi: 10.1165/ajrcmb.24.5.4160 contributor: fullname: Warner – volume: 11 start-page: 352 year: 2017 ident: key 20180908093322_CIT0019 article-title: Mortality prediction to hospitalized patients with influenza pneumonia: PO2 /FiO2 combined lymphocyte count is the answer publication-title: Clin Respir J doi: 10.1111/crj.12346 contributor: fullname: Shi – volume: 208 start-page: 1511 year: 2011 ident: key 20180908093322_CIT0040 article-title: The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice publication-title: J Exp Med doi: 10.1084/jem.20110226 contributor: fullname: Tu – volume: 6 start-page: e17186 year: 2011 ident: key 20180908093322_CIT0036 article-title: Aberrant cell cycle and apoptotic changes characterise severe influenza A infection–a meta-analysis of genomic signatures in circulating leukocytes publication-title: PLoS One doi: 10.1371/journal.pone.0017186 contributor: fullname: Parnell – volume: 4 start-page: e00362-13 year: 2013 ident: key 20180908093322_CIT0024 article-title: Pathogenicity of the novel A/H7N9 influenza virus in mice publication-title: MBio doi: 10.1128/mBio.00362-13 contributor: fullname: Mok – volume: 501 start-page: 551 year: 2013 ident: key 20180908093322_CIT0023 article-title: Characterization of H7N9 influenza A viruses isolated from humans publication-title: Nature doi: 10.1038/nature12392 contributor: fullname: Watanabe – volume: 77 start-page: 568 year: 2009 ident: key 20180908093322_CIT0027 article-title: Neutrophil recruitment to the lungs during bacterial pneumonia publication-title: Infect Immun doi: 10.1128/IAI.00832-08 contributor: fullname: Craig – volume: 10 start-page: e0117846 year: 2015 ident: key 20180908093322_CIT0012 article-title: Clinical, virological and immunological features from patients infected with re-emergent avian-origin human H7N9 influenza disease of varying severity in Guangdong province publication-title: PLoS One doi: 10.1371/journal.pone.0117846 contributor: fullname: Yang – volume: 501 start-page: 556 year: 2013 ident: key 20180908093322_CIT0021 article-title: Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice publication-title: Nature doi: 10.1038/nature12391 contributor: fullname: Belser – volume: 31 start-page: e15 year: 2003 ident: key 20180908093322_CIT0013 article-title: Summaries of Affymetrix GeneChip probe level data publication-title: Nucleic Acids Res doi: 10.1093/nar/gng015 contributor: fullname: Irizarry – volume: 1 start-page: 534 year: 2013 ident: key 20180908093322_CIT0004 article-title: Tropism and innate host responses of a novel avian influenza A H7N9 virus: an analysis of ex-vivo and in-vitro cultures of the human respiratory tract publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(13)70138-3 contributor: fullname: Chan – volume: 368 start-page: 1888 year: 2013 ident: key 20180908093322_CIT0001 article-title: Human infection with a novel avian-origin influenza A (H7N9) virus publication-title: N Engl J Med doi: 10.1056/NEJMoa1304459 contributor: fullname: Gao – volume: 10 start-page: e1001549 year: 2013 ident: key 20180908093322_CIT0009 article-title: Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection publication-title: PLoS Med doi: 10.1371/journal.pmed.1001549 contributor: fullname: Mejias – volume: 10 start-page: R127 year: 2009 ident: key 20180908093322_CIT0015 article-title: Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis publication-title: Genome Biol doi: 10.1186/gb-2009-10-11-r127 contributor: fullname: Pankla – volume: 14 start-page: 123 year: 2002 ident: key 20180908093322_CIT0028 article-title: Molecular mechanisms of neutrophil recruitment elicited by bacteria in the lungs publication-title: Semin Immunol doi: 10.1006/smim.2001.0349 contributor: fullname: Mizgerd – volume: 43 start-page: D1049 year: 2015 ident: key 20180908093322_CIT0016 article-title: Gene Ontology Consortium: going forward publication-title: Nucleic Acids Res doi: 10.1093/nar/gku1179 contributor: fullname: Gene Ontology Consortium |
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| Snippet | Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional... BackgroundAvian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%.... This study correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection with clinical data of patients.... |
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| SubjectTerms | Case-Control Studies Gene Expression Regulation, Viral - immunology Humans Immunity, Cellular - genetics Immunity, Cellular - physiology Influenza A Virus, H7N9 Subtype Influenza, Human - metabolism Influenza, Human - virology Leukocytes - metabolism Lung Major and Brief Reports T-Lymphocytes - metabolism Transcriptome Viral Load |
| Title | Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29846612 https://search.proquest.com/docview/2047260042 https://pubmed.ncbi.nlm.nih.gov/PMC6129114 |
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