Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

• Published in: Aging (Albany, NY.) Vol. 11; no. 21; pp. 9234 - 9263
• Main Authors: Bektas, Arsun, Schurman, Shepherd H., Gonzalez-Freire, Marta, Dunn, Christopher A., Singh, Amit K., Macian, Fernando, Cuervo, Ana Maria, Sen, Ranjan, Ferrucci, Luigi
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 09.11.2019
• Subjects: Adult; Aged; CD4-Positive T-Lymphocytes - metabolism; Cell Respiration; Humans; Immunosenescence; Longitudinal Studies; Mitochondria - metabolism; Mitochondria - ultrastructure; Mitophagy; Priority Research Paper; Young Adult; autophagy; CD4+ T cells; aging; proteomics; mitochondria

To gain understanding on the mechanisms that drive immunosenescence in humans, we examined CD4 T cells obtained from younger (20-39 years-old) and older (70+ years-old) healthy participants of the Baltimore Longitudinal Study on Aging (BLSA). We found that mitochondrial proteins involved in the elec...