Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging

• Published in: Aging (Albany, NY.) Vol. 12; no. 20; pp. 20001 - 20023
• Main Authors: Luciano-Mateo, Fedra, Cabré, Noemí, Baiges-Gaya, Gerard, Fernández-Arroyo, Salvador, Hernández-Aguilera, Anna, Elisabet Rodríguez-Tomàs, Elisabet, Arenas, Meritxell, Camps, Jordi, Menéndez, Javier A, Joven, Jorge
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 26.10.2020
• Subjects: Animals; Animals, Genetically Modified; Autophagy; Cellular Senescence; Chemokine CCL2 - genetics; Chemokine CCL2 - metabolism; Disease Models, Animal; DNA Methylation; Energy Metabolism; Lamin Type A - genetics; Longevity; Male; Mice, Inbred C57BL; Mice, Mutant Strains; Mitochondria, Muscle - genetics; Mitochondria, Muscle - metabolism; Mitochondria, Muscle - pathology; Mitochondrial Dynamics; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Mutation; Progeria - genetics; Progeria - metabolism; Progeria - pathology; Research Paper; Signal Transduction; Up-Regulation; progeria; C-C motif chemokine ligand 2; energy metabolism; one-carbon metabolism

Injection of tissues with senescent cells induces changes that mimic aging, and this process is delayed in mice engineered to eliminate senescent cells, which secrete proinflammatory cytokines, including C-C motif chemokine ligand 2 ( ). Circulating levels of correlate with age, but the impact of on...