Membrane Distribution of the Pseudomonas Quinolone Signal Modulates Outer Membrane Vesicle Production in Pseudomonas aeruginosa

• Published in: mBio Vol. 8; no. 4
• Main Authors: Florez, Catalina, Raab, Julie E., Cooke, Adam C., Schertzer, Jeffrey W.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 08.08.2017
• Subjects: Bacterial Outer Membrane Proteins - metabolism; Bacterial Proteins - metabolism; Bacterial Secretion Systems - metabolism; Cell Membrane - metabolism; Organelle Biogenesis; Pseudomonas aeruginosa - metabolism; Pseudomonas aeruginosa - pathogenicity; Quinolones - metabolism; Quorum Sensing; Virulence Factors - metabolism; Pseudomonas aeruginosa; secretion systems; PQS; quorum sensing; outer membrane vesicles

The Pseudomonas quinolone signal (PQS) is an important quorum-sensing molecule in Pseudomonas aeruginosa that also mediates its own packaging and transport by stimulating outer membrane vesicle (OMV) formation. Because OMVs have been implicated in many virulence-associated behaviors, it is critical...