Recent advancements in flavonoid production through engineering microbial systems
Flavonoids are a class of polyphenolic compounds found in plants that offer extensive health benefits and have applications in the pharmaceutical, cosmetic, and food industries. Currently, flavonoid production largely depends on plant extraction methods, which face limitations owing to low yields an...
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| Published in | Biotechnology and bioprocess engineering Vol. 29; no. 5; pp. 792 - 805 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
The Korean Society for Biotechnology and Bioengineering
01.10.2024
Springer Nature B.V 한국생물공학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-8372 1976-3816 |
| DOI | 10.1007/s12257-024-00125-2 |
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| Abstract | Flavonoids are a class of polyphenolic compounds found in plants that offer extensive health benefits and have applications in the pharmaceutical, cosmetic, and food industries. Currently, flavonoid production largely depends on plant extraction methods, which face limitations owing to low yields and seasonal and environmental impacts. To address these issues, the potential of microbial fermentation, which leverages advances in metabolic engineering and genetic tools, has been discussed as an innovative alternative to overcome these challenges, thus offering an environmentally friendly and sustainable approach to flavonoid production. However, the integration of complex biosynthesis pathways into microbial systems presents challenges such as the inefficient expression of plant-derived genes, metabolic conflicts, and toxicity or feedback inhibition by accumulated flavonoids within the microbial cells. This comprehensive review highlights recent advancements in engineering strategies to address these challenges, focusing on biotransformation, single-strain fermentation, and co-culture systems, each with its own unique characteristics and potential for optimizing flavonoid production in a cost-effective and scalable manner. |
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| AbstractList | Flavonoids are a class of polyphenolic compounds found in plants that offer extensive health benefits and have applications in the pharmaceutical, cosmetic, and food industries. Currently, flavonoid production largely depends on plant extraction methods, which face limitations owing to low yields and seasonal and environmental impacts. To address these issues, the potential of microbial fermentation, which leverages advances in metabolic engineering and genetic tools, has been discussed as an innovative alternative to overcome these challenges, thus offering an environmentally friendly and sustainable approach to flavonoid production. However, the integration of complex biosynthesis pathways into microbial systems presents challenges such as the inefficient expression of plant-derived genes, metabolic conflicts, and toxicity or feedback inhibition by accumulated flavonoids within the microbial cells. This comprehensive review highlights recent advancements in engineering strategies to address these challenges, focusing on biotransformation, single-strain fermentation, and co-culture systems, each with its own unique characteristics and potential for optimizing flavonoid production in a cost-effective and scalable manner. KCI Citation Count: 0 Flavonoids are a class of polyphenolic compounds found in plants that offer extensive health benefits and have applications in the pharmaceutical, cosmetic, and food industries. Currently, flavonoid production largely depends on plant extraction methods, which face limitations owing to low yields and seasonal and environmental impacts. To address these issues, the potential of microbial fermentation, which leverages advances in metabolic engineering and genetic tools, has been discussed as an innovative alternative to overcome these challenges, thus offering an environmentally friendly and sustainable approach to flavonoid production. However, the integration of complex biosynthesis pathways into microbial systems presents challenges such as the inefficient expression of plant-derived genes, metabolic conflicts, and toxicity or feedback inhibition by accumulated flavonoids within the microbial cells. This comprehensive review highlights recent advancements in engineering strategies to address these challenges, focusing on biotransformation, single-strain fermentation, and co-culture systems, each with its own unique characteristics and potential for optimizing flavonoid production in a cost-effective and scalable manner. |
| Author | Hwang, Yunhee Noh, Myung Hyun Jung, Gyoo Yeol |
| Author_xml | – sequence: 1 givenname: Yunhee surname: Hwang fullname: Hwang, Yunhee organization: Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH) – sequence: 2 givenname: Myung Hyun surname: Noh fullname: Noh, Myung Hyun email: mhnoh@krict.re.kr organization: Center for Bio-Based Chemistry, Korea Research Institute of Chemical Technology (KRICT) – sequence: 3 givenname: Gyoo Yeol orcidid: 0000-0002-9742-3207 surname: Jung fullname: Jung, Gyoo Yeol email: gyjung@postech.ac.kr organization: Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology |
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| Copyright_xml | – notice: The Author(s), under exclusive licence to The Korean Society for Biotechnology and Bioengineering and Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Snippet | Flavonoids are a class of polyphenolic compounds found in plants that offer extensive health benefits and have applications in the pharmaceutical, cosmetic,... |
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| StartPage | 792 |
| SubjectTerms | Biosynthesis Biotechnology Biotransformation Cell culture Chemistry Chemistry and Materials Science class coculture cost effectiveness Environmental impact Feedback inhibition Fermentation Flavonoids Food industry Food plants Industrial and Production Engineering Metabolic engineering Metabolism Microorganisms Plant extracts Polyphenols Review Paper Toxicity 생물공학 |
| Title | Recent advancements in flavonoid production through engineering microbial systems |
| URI | https://link.springer.com/article/10.1007/s12257-024-00125-2 https://www.proquest.com/docview/3111347885 https://www.proquest.com/docview/3153839228 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003135504 |
| Volume | 29 |
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| ispartofPNX | Biotechnology and Bioprocess Engineering, 2024, 29(5), , pp.792-805 |
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