Intravenous human rabies immunoglobulin for post-exposure prophylaxis: serum rabies neutralizing antibody concentrations and side-effects

• Published in: Journal of biological standardization Vol. 17; no. 1; pp. 91 - 104
• Main Authors: Aoki, Fred Y., Rubin, Margaret E., Friesen, Albert D., Bowman, John M., Saunders, J.Robert
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Science (USA) 1989; Academic Press
• Subjects: Antibodies, Viral - administration & dosage; Antibodies, Viral - biosynthesis; Biological and medical sciences; Clinical Trials as Topic; Fundamental and applied biological sciences. Psychology; Humans; Immunization, Passive - adverse effects; Immunoglobulins - administration & dosage; Injections, Intramuscular; Injections, Intravenous; Microbiology; Neutralization Tests; Rabies - immunology; Rabies - prevention & control; Rabies Vaccines - administration & dosage; Rabies Vaccines - adverse effects; Rabies virus - immunology; Random Allocation; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Virology; Human; Immunoglobulins; Nervous system diseases; Intravenous administration; Antibody; Vaccine; Intramuscular administration; Active immunization; Infection; Immunoprophylaxis; Neutralization test; Viral disease; Rabies; Secondary effect; Serum; Passive immunization; Comparative study

The beneficial effect of passive immunization for post-exposure rabies prophylaxis is associated with the appearance of serum neutralizing antibody (SNA) earlier than occurs with vaccine alone. We compared the SNA response and the side-effects in 30 previously unimmunized healthy volunteers given a...