Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates

• Published in: Journal of neurophysiology Vol. 110; no. 3; pp. 577 - 586
• Main Authors: Furman, Adam C., Kujawa, Sharon G., Liberman, M. Charles
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2013
• Subjects: Animals; Cochlea - pathology; Cochlear Nerve - pathology; Cochlear Nerve - physiopathology; Female; Guinea Pigs; Hair Cells, Auditory - pathology; Hearing Loss, Noise-Induced - pathology; Hearing Loss, Noise-Induced - physiopathology; Vestibulocochlear Nerve Diseases - pathology; Vestibulocochlear Nerve Diseases - physiopathology; auditory nerve; excitotoxicity; noise-induced hearing loss

Acoustic overexposure can cause a permanent loss of auditory nerve fibers without destroying cochlear sensory cells, despite complete recovery of cochlear thresholds ( Kujawa and Liberman 2009 ), as measured by gross neural potentials such as the auditory brainstem response (ABR). To address this no...