Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates
Acoustic overexposure can cause a permanent loss of auditory nerve fibers without destroying cochlear sensory cells, despite complete recovery of cochlear thresholds ( Kujawa and Liberman 2009 ), as measured by gross neural potentials such as the auditory brainstem response (ABR). To address this no...
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| Published in | Journal of neurophysiology Vol. 110; no. 3; pp. 577 - 586 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Physiological Society
01.08.2013
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Acoustic overexposure can cause a permanent loss of auditory nerve fibers without destroying cochlear sensory cells, despite complete recovery of cochlear thresholds ( Kujawa and Liberman 2009 ), as measured by gross neural potentials such as the auditory brainstem response (ABR). To address this nominal paradox, we recorded responses from single auditory nerve fibers in guinea pigs exposed to this type of neuropathic noise (4- to 8-kHz octave band at 106 dB SPL for 2 h). Two weeks postexposure, ABR thresholds had recovered to normal, while suprathreshold ABR amplitudes were reduced. Both thresholds and amplitudes of distortion-product otoacoustic emissions fully recovered, suggesting recovery of hair cell function. Loss of up to 30% of auditory-nerve synapses on inner hair cells was confirmed by confocal analysis of the cochlear sensory epithelium immunostained for pre- and postsynaptic markers. In single fiber recordings, at 2 wk postexposure, frequency tuning, dynamic range, postonset adaptation, first-spike latency and its variance, and other basic properties of auditory nerve response were all completely normal in the remaining fibers. The only physiological abnormality was a change in population statistics suggesting a selective loss of fibers with low- and medium-spontaneous rates. Selective loss of these high-threshold fibers would explain how ABR thresholds can recover despite such significant noise-induced neuropathy. A selective loss of high-threshold fibers may contribute to the problems of hearing in noisy environments that characterize the aging auditory system. |
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| AbstractList | Acoustic overexposure can cause a permanent loss of auditory nerve fibers without destroying cochlear sensory cells, despite complete recovery of cochlear thresholds (Kujawa and Liberman 2009), as measured by gross neural potentials such as the auditory brainstem response (ABR). To address this nominal paradox, we recorded responses from single auditory nerve fibers in guinea pigs exposed to this type of neuropathic noise (4- to 8-kHz octave band at 106 dB SPL for 2 h). Two weeks postexposure, ABR thresholds had recovered to normal, while suprathreshold ABR amplitudes were reduced. Both thresholds and amplitudes of distortion-product otoacoustic emissions fully recovered, suggesting recovery of hair cell function. Loss of up to 30% of auditory-nerve synapses on inner hair cells was confirmed by confocal analysis of the cochlear sensory epithelium immunostained for pre- and postsynaptic markers. In single fiber recordings, at 2 wk postexposure, frequency tuning, dynamic range, postonset adaptation, first-spike latency and its variance, and other basic properties of auditory nerve response were all completely normal in the remaining fibers. The only physiological abnormality was a change in population statistics suggesting a selective loss of fibers with low- and medium-spontaneous rates. Selective loss of these high-threshold fibers would explain how ABR thresholds can recover despite such significant noise-induced neuropathy. A selective loss of high-threshold fibers may contribute to the problems of hearing in noisy environments that characterize the aging auditory system.Acoustic overexposure can cause a permanent loss of auditory nerve fibers without destroying cochlear sensory cells, despite complete recovery of cochlear thresholds (Kujawa and Liberman 2009), as measured by gross neural potentials such as the auditory brainstem response (ABR). To address this nominal paradox, we recorded responses from single auditory nerve fibers in guinea pigs exposed to this type of neuropathic noise (4- to 8-kHz octave band at 106 dB SPL for 2 h). Two weeks postexposure, ABR thresholds had recovered to normal, while suprathreshold ABR amplitudes were reduced. Both thresholds and amplitudes of distortion-product otoacoustic emissions fully recovered, suggesting recovery of hair cell function. Loss of up to 30% of auditory-nerve synapses on inner hair cells was confirmed by confocal analysis of the cochlear sensory epithelium immunostained for pre- and postsynaptic markers. In single fiber recordings, at 2 wk postexposure, frequency tuning, dynamic range, postonset adaptation, first-spike latency and its variance, and other basic properties of auditory nerve response were all completely normal in the remaining fibers. The only physiological abnormality was a change in population statistics suggesting a selective loss of fibers with low- and medium-spontaneous rates. Selective loss of these high-threshold fibers would explain how ABR thresholds can recover despite such significant noise-induced neuropathy. A selective loss of high-threshold fibers may contribute to the problems of hearing in noisy environments that characterize the aging auditory system. Acoustic overexposure can cause a permanent loss of auditory nerve fibers without destroying cochlear sensory cells, despite complete recovery of cochlear thresholds ( Kujawa and Liberman 2009 ), as measured by gross neural potentials such as the auditory brainstem response (ABR). To address this nominal paradox, we recorded responses from single auditory nerve fibers in guinea pigs exposed to this type of neuropathic noise (4- to 8-kHz octave band at 106 dB SPL for 2 h). Two weeks postexposure, ABR thresholds had recovered to normal, while suprathreshold ABR amplitudes were reduced. Both thresholds and amplitudes of distortion-product otoacoustic emissions fully recovered, suggesting recovery of hair cell function. Loss of up to 30% of auditory-nerve synapses on inner hair cells was confirmed by confocal analysis of the cochlear sensory epithelium immunostained for pre- and postsynaptic markers. In single fiber recordings, at 2 wk postexposure, frequency tuning, dynamic range, postonset adaptation, first-spike latency and its variance, and other basic properties of auditory nerve response were all completely normal in the remaining fibers. The only physiological abnormality was a change in population statistics suggesting a selective loss of fibers with low- and medium-spontaneous rates. Selective loss of these high-threshold fibers would explain how ABR thresholds can recover despite such significant noise-induced neuropathy. A selective loss of high-threshold fibers may contribute to the problems of hearing in noisy environments that characterize the aging auditory system. Acoustic overexposure can cause a permanent loss of auditory nerve fibers without destroying cochlear sensory cells, despite complete recovery of cochlear thresholds ( Kujawa and Liberman 2009 ), as measured by gross neural potentials such as the auditory brainstem response (ABR). To address this nominal paradox, we recorded responses from single auditory nerve fibers in guinea pigs exposed to this type of neuropathic noise (4- to 8-kHz octave band at 106 dB SPL for 2 h). Two weeks postexposure, ABR thresholds had recovered to normal, while suprathreshold ABR amplitudes were reduced. Both thresholds and amplitudes of distortion-product otoacoustic emissions fully recovered, suggesting recovery of hair cell function. Loss of up to 30% of auditory-nerve synapses on inner hair cells was confirmed by confocal analysis of the cochlear sensory epithelium immunostained for pre- and postsynaptic markers. In single fiber recordings, at 2 wk postexposure, frequency tuning, dynamic range, postonset adaptation, first-spike latency and its variance, and other basic properties of auditory nerve response were all completely normal in the remaining fibers. The only physiological abnormality was a change in population statistics suggesting a selective loss of fibers with low- and medium-spontaneous rates. Selective loss of these high-threshold fibers would explain how ABR thresholds can recover despite such significant noise-induced neuropathy. A selective loss of high-threshold fibers may contribute to the problems of hearing in noisy environments that characterize the aging auditory system. |
| Author | Liberman, M. Charles Kujawa, Sharon G. Furman, Adam C. |
| Author_xml | – sequence: 1 givenname: Adam C. surname: Furman fullname: Furman, Adam C. organization: Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts;, Harvard Program in Speech and Hearing Bioscience and Technology, Boston, Massachusetts – sequence: 2 givenname: Sharon G. surname: Kujawa fullname: Kujawa, Sharon G. organization: Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts;, Department of Audiology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; and, Harvard Program in Speech and Hearing Bioscience and Technology, Boston, Massachusetts – sequence: 3 givenname: M. Charles surname: Liberman fullname: Liberman, M. Charles organization: Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts;, Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts;, Harvard Program in Speech and Hearing Bioscience and Technology, Boston, Massachusetts |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23596328$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1121/1.381736 10.1113/jphysiol.2004.069559 10.1016/0378-5955(90)90120-E 10.1002/(SICI)1096-9861(19970505)381:2<188::AID-CNE6>3.0.CO;2-# 10.1002/cne.903010309 10.1016/0378-5955(84)90032-7 10.1523/JNEUROSCI.0389-10.2010 10.1121/1.387994 10.1002/cne.903130205 10.1016/0378-5955(88)90105-0 10.1080/14992020500377089 10.1007/s10162-012-0344-1 10.1016/0378-5955(88)90061-5 10.1016/j.heares.2006.07.014 10.1523/JNEUROSCI.3389-10.2011 10.1007/s10162-011-0277-0 10.1126/science.7079757 10.1523/JNEUROSCI.2156-11.2011 10.1002/(SICI)1096-9861(19960722)371:2<208::AID-CNE2>3.0.CO;2-6 10.1152/jn.1996.76.4.2799 10.1016/0378-5955(95)00178-6 10.1523/JNEUROSCI.2845-09.2009 10.1523/JNEUROSCI.1996-07.2007 10.1016/j.ceca.2010.01.003 10.3109/00016489309135819 10.1523/JNEUROSCI.23-36-11296.2003 10.1016/0378-5955(80)90007-6 10.1152/jn.1984.51.6.1326 10.1016/0378-5955(83)90031-X 10.3109/00016486909125448 10.1016/0378-5955(84)90024-8 10.1016/0378-5955(89)90115-9 10.1152/jn.00574.2004 10.1121/1.388677 10.1002/cne.22644 |
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| Snippet | Acoustic overexposure can cause a permanent loss of auditory nerve fibers without destroying cochlear sensory cells, despite complete recovery of cochlear... |
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| SubjectTerms | Animals Cochlea - pathology Cochlear Nerve - pathology Cochlear Nerve - physiopathology Female Guinea Pigs Hair Cells, Auditory - pathology Hearing Loss, Noise-Induced - pathology Hearing Loss, Noise-Induced - physiopathology Vestibulocochlear Nerve Diseases - pathology Vestibulocochlear Nerve Diseases - physiopathology |
| Title | Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23596328 https://www.proquest.com/docview/1417534471 https://pubmed.ncbi.nlm.nih.gov/PMC3742994 |
| Volume | 110 |
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