Evaluation of the Maintained Effect of 3% Hypertonic Saline Solution in an Animal Model of Intracranial Hypertension

• Published in: Medical science monitor. Basic research Vol. 22; pp. 123 - 127
• Main Authors: Sousa, Jr, Leonardo M, de Andrade, Almir F, Belon, Alessandro R, Soares, Matheus S, Amorim, Robson Luis, Otochi, Jose Pinhata, Teixeira, Manoel J, Paiva, Wellingson S
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 25.10.2016
• Subjects: Animal Studies; Animals; Brain - physiopathology; Disease Models, Animal; Female; Intracranial Hypertension - physiopathology; Intracranial Hypertension - rehabilitation; Intracranial Hypertension - therapy; Intracranial Pressure - physiology; Male; Saline Solution, Hypertonic - administration & dosage; Swine

BACKGROUND Current clinical treatment methods for refractory intracranial hypertension include elevation of the decubitus, ventilation adjustment, and use of hypertonic solutions such as hypertonic saline and mannitol solutions. Previous studies have shown that hypertonic solutions are particularly...