The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis
Sepsis-induced acute lung injury (ALI) is a severe cause of death. Increasing evidence has identified circular RNAs (circRNAs) acting as critical regulators of human diseases. However, their expression pattern and underlying mechanisms in ALI remain unclear. Herein, we screened the circRNAs of ALI p...
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| Published in | Aging (Albany, NY.) Vol. 14; no. 12; pp. 5059 - 5074 |
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| Main Authors | , , , , , , , |
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| Abstract | Sepsis-induced acute lung injury (ALI) is a severe cause of death. Increasing evidence has identified circular RNAs (circRNAs) acting as critical regulators of human diseases. However, their expression pattern and underlying mechanisms in ALI remain unclear. Herein, we screened the circRNAs of ALI patients and constructed a lung injury murine model using lipopolysaccharides (LPS) induction. Functional analyses of targeted circRNA were performed
and
. Then, the downstream miRNA and mRNA of specific circRNAs were identified. Compared to healthy subjects, 35 circRNAs were upregulated and 9 circRNAs were downregulated in sepsis patients. The top 10 differentially expressed circRNAs were selected for validation and has_circ_0003091 was selected. The ALI mice presented significantly elevated has_circ_0003091 (mmu_circ_0015268). The functional analysis revealed that mmu_circ_0015268 contributed to the pulmonary injury, cell apoptosis, inflammatory responses, and endothelial activation in the ALI murine model. On the other hand, silencing mmu_circ_0015268 showed protective effects in LPS-treated mice and PMVECs. Furthermore, mmu_circ_0015268 sponged miR-149 to upregulate the expression of its target Smad2. In summary, we demonstrated that has_circ_0003091 might be a novel target for the management and treatment of sepsis-induced ALI. |
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| AbstractList | Sepsis-induced acute lung injury (ALI) is a severe cause of death. Increasing evidence has identified circular RNAs (circRNAs) acting as critical regulators of human diseases. However, their expression pattern and underlying mechanisms in ALI remain unclear. Herein, we screened the circRNAs of ALI patients and constructed a lung injury murine model using lipopolysaccharides (LPS) induction. Functional analyses of targeted circRNA were performed
in vivo
and
in vitro
. Then, the downstream miRNA and mRNA of specific circRNAs were identified. Compared to healthy subjects, 35 circRNAs were upregulated and 9 circRNAs were downregulated in sepsis patients. The top 10 differentially expressed circRNAs were selected for validation and has_circ_0003091 was selected. The ALI mice presented significantly elevated has_circ_0003091 (mmu_circ_0015268). The functional analysis revealed that mmu_circ_0015268 contributed to the pulmonary injury, cell apoptosis, inflammatory responses, and endothelial activation in the ALI murine model. On the other hand, silencing mmu_circ_0015268 showed protective effects in LPS-treated mice and PMVECs. Furthermore, mmu_circ_0015268 sponged miR-149 to upregulate the expression of its target Smad2. In summary, we demonstrated that has_circ_0003091 might be a novel target for the management and treatment of sepsis-induced ALI. Sepsis-induced acute lung injury (ALI) is a severe cause of death. Increasing evidence has identified circular RNAs (circRNAs) acting as critical regulators of human diseases. However, their expression pattern and underlying mechanisms in ALI remain unclear. Herein, we screened the circRNAs of ALI patients and constructed a lung injury murine model using lipopolysaccharides (LPS) induction. Functional analyses of targeted circRNA were performed and . Then, the downstream miRNA and mRNA of specific circRNAs were identified. Compared to healthy subjects, 35 circRNAs were upregulated and 9 circRNAs were downregulated in sepsis patients. The top 10 differentially expressed circRNAs were selected for validation and has_circ_0003091 was selected. The ALI mice presented significantly elevated has_circ_0003091 (mmu_circ_0015268). The functional analysis revealed that mmu_circ_0015268 contributed to the pulmonary injury, cell apoptosis, inflammatory responses, and endothelial activation in the ALI murine model. On the other hand, silencing mmu_circ_0015268 showed protective effects in LPS-treated mice and PMVECs. Furthermore, mmu_circ_0015268 sponged miR-149 to upregulate the expression of its target Smad2. In summary, we demonstrated that has_circ_0003091 might be a novel target for the management and treatment of sepsis-induced ALI. Sepsis-induced acute lung injury (ALI) is a severe cause of death. Increasing evidence has identified circular RNAs (circRNAs) acting as critical regulators of human diseases. However, their expression pattern and underlying mechanisms in ALI remain unclear. Herein, we screened the circRNAs of ALI patients and constructed a lung injury murine model using lipopolysaccharides (LPS) induction. Functional analyses of targeted circRNA were performed in vivo and in vitro. Then, the downstream miRNA and mRNA of specific circRNAs were identified. Compared to healthy subjects, 35 circRNAs were upregulated and 9 circRNAs were downregulated in sepsis patients. The top 10 differentially expressed circRNAs were selected for validation and has_circ_0003091 was selected. The ALI mice presented significantly elevated has_circ_0003091 (mmu_circ_0015268). The functional analysis revealed that mmu_circ_0015268 contributed to the pulmonary injury, cell apoptosis, inflammatory responses, and endothelial activation in the ALI murine model. On the other hand, silencing mmu_circ_0015268 showed protective effects in LPS-treated mice and PMVECs. Furthermore, mmu_circ_0015268 sponged miR-149 to upregulate the expression of its target Smad2. In summary, we demonstrated that has_circ_0003091 might be a novel target for the management and treatment of sepsis-induced ALI.Sepsis-induced acute lung injury (ALI) is a severe cause of death. Increasing evidence has identified circular RNAs (circRNAs) acting as critical regulators of human diseases. However, their expression pattern and underlying mechanisms in ALI remain unclear. Herein, we screened the circRNAs of ALI patients and constructed a lung injury murine model using lipopolysaccharides (LPS) induction. Functional analyses of targeted circRNA were performed in vivo and in vitro. Then, the downstream miRNA and mRNA of specific circRNAs were identified. Compared to healthy subjects, 35 circRNAs were upregulated and 9 circRNAs were downregulated in sepsis patients. The top 10 differentially expressed circRNAs were selected for validation and has_circ_0003091 was selected. The ALI mice presented significantly elevated has_circ_0003091 (mmu_circ_0015268). The functional analysis revealed that mmu_circ_0015268 contributed to the pulmonary injury, cell apoptosis, inflammatory responses, and endothelial activation in the ALI murine model. On the other hand, silencing mmu_circ_0015268 showed protective effects in LPS-treated mice and PMVECs. Furthermore, mmu_circ_0015268 sponged miR-149 to upregulate the expression of its target Smad2. In summary, we demonstrated that has_circ_0003091 might be a novel target for the management and treatment of sepsis-induced ALI. |
| Author | Zheng, Xiao-Xiao Sun, Li-Chao Zhang, Guo-Qiang Yan, Shen-Tao Shen, Mei-Jia Li, Wen Chen, Xu Zhang, Xiao-Yan |
| Author_xml | – sequence: 1 givenname: Mei-Jia surname: Shen fullname: Shen, Mei-Jia organization: Emergency Department, China-Japan Friendship Hospital, Beijing 100029, China, Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China – sequence: 2 givenname: Shen-Tao surname: Yan fullname: Yan, Shen-Tao organization: Emergency Department, China-Japan Friendship Hospital, Beijing 100029, China – sequence: 3 givenname: Xiao-Yan surname: Zhang fullname: Zhang, Xiao-Yan organization: Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China – sequence: 4 givenname: Wen surname: Li fullname: Li, Wen organization: Surgical Intensive Care Unit (SICU), China-Japan Friendship Hospital, Beijing 100029, China – sequence: 5 givenname: Xu surname: Chen fullname: Chen, Xu organization: Department of Digestive, Beijing Ditan Hospital Capital Medical University, Beijing 100015, China – sequence: 6 givenname: Xiao-Xiao surname: Zheng fullname: Zheng, Xiao-Xiao organization: Department of Emergency, Peking University People's Hospital (PKUPH), Beijing 100044, China – sequence: 7 givenname: Guo-Qiang surname: Zhang fullname: Zhang, Guo-Qiang organization: Emergency Department, China-Japan Friendship Hospital, Beijing 100029, China, Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China – sequence: 8 givenname: Li-Chao surname: Sun fullname: Sun, Li-Chao organization: Emergency Department, China-Japan Friendship Hospital, Beijing 100029, China |
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| Cites_doi | 10.1038/s41576-019-0158-7 10.1161/CIRCULATIONAHA.117.029004 10.1111/jcmm.15685 10.1080/15476286.2015.1020271 10.1007/978-981-13-1426-1_6 10.1016/j.heliyon.2020.e04532 10.1089/jamp.2009.0775 10.7150/thno.42174 10.1016/j.redox.2021.102200 10.1111/jcmm.14858 10.1016/j.gene.2020.144900 10.1080/15384047.2019.1669995 10.1164/rccm.201106-0965OC 10.1158/0008-5472.CAN-19-1934 10.1007/s10753-019-01060-8 10.1111/jcmm.15324 10.1007/s10753-021-01548-2 10.3892/or.2017.6047 10.1111/jcmm.14577 10.1056/NEJMoa050333 10.1002/cbin.11235 10.1016/j.yexcr.2018.05.002 10.1002/jgm.3261 |
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| Keywords | Smad2 has_circ_0003091 acute lung injury sepsis |
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| References | Olayioye (18) 2020; 8 Matthay (2) 2010; 2 Li (16) 2022; 4 Liu (7) 2019; 4 Shen (23) 2020; 2 Sethi (22) 2012; 18 Yan (8) 2017; 13 Geng (15) 2020; 2 Huang (17) 2020; 1 Sun (20) 2020; 2 He (14) 2020; 2 Chen (10) 2020; 2 Tang (6) 2019; 2 Xiong (19) 2017; 3 Yang (21) 2019 Chen (5) 2018; 36 Li (12) 2020; 6 Hudson (1) 2005; 35 Panda (4) 2018; 108 Cai (11) 2021; 4 Kjems (13) 2019; 2 Wang (9) 2020; 75 Yang (3) 2015; 1 |
| References_xml | – volume: 2 start-page: 675 year: 2019 ident: 13 article-title: The biogenesis, biology and characterization of circular RNAs. publication-title: Nat Rev Genet doi: 10.1038/s41576-019-0158-7 – volume: 13 start-page: 1629 year: 2017 ident: 8 article-title: Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus. publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.029004 – volume: 2 start-page: 11221 year: 2020 ident: 15 article-title: CircC3P1 attenuated pro-inflammatory cytokine production and cell apoptosis in acute lung injury induced by sepsis through modulating miR-21. publication-title: J Cell Mol Med doi: 10.1111/jcmm.15685 – volume: 1 start-page: 381 year: 2015 ident: 3 article-title: Regulation of circRNA biogenesis. publication-title: RNA Biol doi: 10.1080/15476286.2015.1020271 – volume: 108 start-page: 67 year: 2018 ident: 4 article-title: Circular RNAs Act as miRNA Sponges. publication-title: Adv Exp Med Biol doi: 10.1007/978-981-13-1426-1_6 – volume: 6 start-page: e04532 year: 2020 ident: 12 article-title: Circular RNA expression in the lungs of a mouse model of sepsis induced by cecal ligation and puncture. publication-title: Heliyon doi: 10.1016/j.heliyon.2020.e04532 – volume: 2 start-page: 243 year: 2010 ident: 2 article-title: Acute lung injury: epidemiology, pathogenesis, and treatment. publication-title: J Aerosol Med Pulm Drug Deliv doi: 10.1089/jamp.2009.0775 – volume: 1 start-page: 3503 year: 2020 ident: 17 article-title: Circular RNA-protein interactions: functions, mechanisms, and identification. publication-title: Theranostics doi: 10.7150/thno.42174 – volume: 4 start-page: 102200 year: 2021 ident: 11 article-title: Erratum to Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction, Redox Biology 36 (2020) 101638. publication-title: Redox Biol doi: 10.1016/j.redox.2021.102200 – volume: 2 start-page: 1658 year: 2020 ident: 23 article-title: Neutrophil extracellular traps activate lung fibroblast to induce polymyositis-related interstitial lung diseases via TLR9-miR-7-Smad2 pathway. publication-title: J Cell Mol Med doi: 10.1111/jcmm.14858 – volume: 75 start-page: 144900 year: 2020 ident: 9 article-title: Circular RNA circ_0003645 silencing alleviates inflammation and apoptosis via the NF-κB pathway in endothelial cells induced by oxLDL. publication-title: Gene doi: 10.1016/j.gene.2020.144900 – volume: 2 start-page: 113 year: 2020 ident: 20 article-title: Circular RNA HIPK3 induces cell proliferation and inhibits apoptosis in non-small cell lung cancer through sponging miR-149. publication-title: Cancer Biol Ther doi: 10.1080/15384047.2019.1669995 – volume: 18 start-page: 537 year: 2012 ident: 22 article-title: Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201106-0965OC – volume: 8 start-page: 1330 year: 2020 ident: 18 article-title: miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions with Macrophages. publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-19-1934 – volume: 4 start-page: 1990 year: 2019 ident: 7 article-title: Characterization of Circular RNA and microRNA Profiles in Septic Myocardial Depression: a Lipopolysaccharide-Induced Rat Septic Shock Model. publication-title: Inflammation doi: 10.1007/s10753-019-01060-8 – volume: 2 start-page: 6731 year: 2020 ident: 10 article-title: Down-regulation of circDMNT3B is conducive to intestinal mucosal permeability dysfunction of rats with sepsis via sponging miR-20b-5p. publication-title: J Cell Mol Med doi: 10.1111/jcmm.15324 – volume: 4 start-page: 331 year: 2022 ident: 16 article-title: Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway. publication-title: Inflammation doi: 10.1007/s10753-021-01548-2 – volume: 3 start-page: 3522 year: 2017 ident: 19 article-title: miR-149 suppresses human non-small cell lung cancer growth and metastasis by inhibiting the FOXM1/cyclin D1/MMP2 axis. publication-title: Oncol Rep doi: 10.3892/or.2017.6047 – volume: 2 start-page: 7111 year: 2019 ident: 6 article-title: Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury. publication-title: J Cell Mol Med doi: 10.1111/jcmm.14577 – volume: 35 start-page: 1685 year: 2005 ident: 1 article-title: Incidence and outcomes of acute lung injury. publication-title: N Engl J Med doi: 10.1056/NEJMoa050333 – year: 2019 ident: 21 article-title: Long non-coding RNA MALAT1 sponges miR-149 to promote inflammatory responses of LPS-induced acute lung injury by targeting MyD88. publication-title: Cell Biol Int doi: 10.1002/cbin.11235 – volume: 36 start-page: 147 year: 2018 ident: 5 article-title: The mechanism and function of circular RNAs in human diseases. publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2018.05.002 – volume: 2 start-page: e3261 year: 2020 ident: 14 article-title: Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression. publication-title: J Gene Med doi: 10.1002/jgm.3261 |
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| Snippet | Sepsis-induced acute lung injury (ALI) is a severe cause of death. Increasing evidence has identified circular RNAs (circRNAs) acting as critical regulators of... |
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| Title | The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis |
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