Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value

• Published in: Nature communications Vol. 6; no. 1; p. 5899
• Main Authors: Stirzaker, Clare, Zotenko, Elena, Song, Jenny Z., Qu, Wenjia, Nair, Shalima S., Locke, Warwick J., Stone, Andrew, Armstong, Nicola J., Robinson, Mark D., Dobrovic, Alexander, Avery-Kiejda, Kelly A., Peters, Kate M., French, Juliet D., Stein, Sandra, Korbie, Darren J., Trau, Matt, Forbes, John F., Scott, Rodney J., Brown, Melissa A., Francis, Glenn D., Clark, Susan J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.02.2015; Nature Publishing Group
• Subjects: 13/106; 631/208/514/1948; 692/699/67/1347; 692/699/67/68/2486; 692/700/1750; Breast cancer; Deoxyribonucleic acid; DNA; DNA Methylation - genetics; DNA Methylation - physiology; Epigenomics; Female; Humanities and Social Sciences; Humans; Methylation; Molecular Sequence Data; multidisciplinary; Prognosis; Science; Science (multidisciplinary); Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - pathology

Epigenetic alterations in the cancer methylome are common in breast cancer and provide novel options for tumour stratification. Here, we perform whole-genome methylation capture sequencing on small amounts of DNA isolated from formalin-fixed, paraffin-embedded tissue from triple-negative breast canc...