Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophrenia

• Published in: Psychopharmacologia Vol. 176; no. 3-4; pp. 369 - 375
• Main Authors: Elman, Igor, Rott, David, Green, Alan I., Langleben, Daniel D., Lukas, Scott E., Goldstein, David S., Breier, Alan
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.11.2004; Springer Nature B.V
• Subjects: Adult; Antimetabolites - administration & dosage; Antimetabolites - pharmacology; Biological and medical sciences; Blood Glucose - metabolism; Catecholamines; Catecholamines - blood; Deoxyglucose - administration & dosage; Deoxyglucose - pharmacology; Dose-Response Relationship, Drug; Epinephrine - blood; Female; Glucose; Homeostasis; Humans; Insulin resistance; Male; Medical sciences; Metabolism; Metabolites; Neuropharmacology; Norepinephrine - blood; Pharmacology. Drug treatments; Physiology; Plasma; Positron-Emission Tomography; Psychiatric Status Rating Scales; Psychiatry; Schizophrenia; Schizophrenia - blood; Sympathetic Nervous System - drug effects; Sympathetic Nervous System - metabolism; Psychosis; Epinephrine; Human; 2-Deoxyglucose; Biological fluid; Schizophrenia; Norepinephrine; Glucose; Glucoprivation; Catecholamine; Blood plasma; Dihydroxyphenylglycol

Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function. The aim of this study was to investigate these alterations during a perturbed homeostatic state. Fifteen patients with schizophrenia and 13 healthy i...