The roles of hippocampal microRNAs in response to acute postnatal exposure to di(2-ethylhexyl) phthalate in female and male rats

• Published in: Neurotoxicology (Park Forest South) Vol. 59; pp. 98 - 104
• Main Authors: Luu, Bryan E., Green, Stuart R., Childers, Christine L., Holahan, Matthew R., Storey, Kenneth B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017; Elsevier BV
• Subjects: Age Factors; Animals; Brain; Dendrite; Dendritic structure; Diethylhexyl Phthalate - pharmacology; Dose-Response Relationship, Drug; Exposure; Female; Females; Gene Expression Regulation, Developmental - drug effects; Gene regulation; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Humans; Infant, Newborn; Male; Males; MicroRNAs - metabolism; miRNA; Neurotoxicity; Non-coding RNA; Plasticizer; Plasticizers - pharmacology; Rats; Ribonucleic acid; RNA; Rodents; Sex Characteristics; Neurotoxicity; Plasticizer; Non-coding RNA; Gene regulation; Hippocampus; Dendrite

•Female CA3 neuron dendrites are resilient to DEHP-induced effects seen in males.•DEHP decreases male hippocampal microRNA levels & increases female microRNA levels.•DEHP lowers miR-132-3p, -191-5p levels in males, but levels increase in females.•MiR-132-3p, −191-5p have been previously shown to...