The roles of hippocampal microRNAs in response to acute postnatal exposure to di(2-ethylhexyl) phthalate in female and male rats

•Female CA3 neuron dendrites are resilient to DEHP-induced effects seen in males.•DEHP decreases male hippocampal microRNA levels & increases female microRNA levels.•DEHP lowers miR-132-3p, -191-5p levels in males, but levels increase in females.•MiR-132-3p, −191-5p have been previously shown to...

Full description

Saved in:
Bibliographic Details
Published inNeurotoxicology (Park Forest South) Vol. 59; pp. 98 - 104
Main Authors Luu, Bryan E., Green, Stuart R., Childers, Christine L., Holahan, Matthew R., Storey, Kenneth B.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2017
Elsevier BV
Subjects
Online AccessGet full text

Cover

Loading…
Abstract •Female CA3 neuron dendrites are resilient to DEHP-induced effects seen in males.•DEHP decreases male hippocampal microRNA levels & increases female microRNA levels.•DEHP lowers miR-132-3p, -191-5p levels in males, but levels increase in females.•MiR-132-3p, −191-5p have been previously shown to regulate dendrite development.•DEHP may affect dendrite morphology through sex-specific regulation of microRNAs. Previous studies have shown that di(2-ethylhexyl) phthalate (DEHP) exposure impairs the normal development of pre- and post-synaptic elements of the male, but not female, rat hippocampus. While males seem to be vulnerable to the neurodevelopmental deficits resulting from DEHP exposure, females appear to show a protective response. The purpose of the present study was to characterize hippocampal microRNAs in female and male rats exposed to DEHP to assess whether any patterns emerged that would be consistent with vulnerability in males and resilience in females. Male and female rats were treated with 0, 1, 10, or 20mg/kg of DEHP by intraperitoneal injections from postnatal day 16 (PND16) − PND22 and brains were removed and flash frozen on PND78. A group of 85 microRNAs which have been previously shown to play a role in the development and maintenance of hippocampal neurons was assessed with RT-qPCR. In response to DEHP exposure, there were 19 microRNAs that increased in females and 52 that decreased in males. The strongest microRNA response in females occurred in conjunction with the 10mg/kg of DEHP dose, whereas suppression of microRNAs in males appeared to be dose-dependent. Select hippocampal microRNAs (such as miR-132-3p and miR-191-5p), previously shown to regulate dendrite morphology, were modulated by DEHP exposure in this study. The results suggest that DEHP exposure has the potential to regulate microRNAs in a sex-specific manner which may interfere with proper hippocampal development in males and preserve hippocampal development in females.
AbstractList Previous studies have shown that di(2-ethylhexyl) phthalate (DEHP) exposure impairs the normal development of pre- and post-synaptic elements of the male, but not female, rat hippocampus. While males seem to be vulnerable to the neurodevelopmental deficits resulting from DEHP exposure, females appear to show a protective response. The purpose of the present study was to characterize hippocampal microRNAs in female and male rats exposed to DEHP to assess whether any patterns emerged that would be consistent with vulnerability in males and resilience in females. Male and female rats were treated with 0, 1, 10, or 20 mg/kg of DEHP by intraperitoneal injections from postnatal day 16 (PND16)-PND22 and brains were removed and flash frozen on PND78. A group of 85 microRNAs which have been previously shown to play a role in the development and maintenance of hippocampal neurons was assessed with RT-qPCR. In response to DEHP exposure, there were 19 microRNAs that increased in females and 52 that decreased in males. The strongest microRNA response in females occurred in conjunction with the 10 mg/kg of DEHP dose, whereas suppression of microRNAs in males appeared to be dose-dependent. Select hippocampal microRNAs (such as miR-132-3p and miR-191-5p), previously shown to regulate dendrite morphology, were modulated by DEHP exposure in this study. The results suggest that DEHP exposure has the potential to regulate microRNAs in a sex-specific manner which may interfere with proper hippocampal development in males and preserve hippocampal development in females.
Previous studies have shown that di(2-ethylhexyl) phthalate (DEHP) exposure impairs the normal development of pre- and post-synaptic elements of the male, but not female, rat hippocampus. While males seem to be vulnerable to the neurodevelopmental deficits resulting from DEHP exposure, females appear to show a protective response. The purpose of the present study was to characterize hippocampal microRNAs in female and male rats exposed to DEHP to assess whether any patterns emerged that would be consistent with vulnerability in males and resilience in females. Male and female rats were treated with 0, 1, 10, or 20mg/kg of DEHP by intraperitoneal injections from postnatal day 16 (PND16) - PND22 and brains were removed and flash frozen on PND78. A group of 85 microRNAs which have been previously shown to play a role in the development and maintenance of hippocampal neurons was assessed with RT-qPCR. In response to DEHP exposure, there were 19 microRNAs that increased in females and 52 that decreased in males. The strongest microRNA response in females occurred in conjunction with the 10mg/kg of DEHP dose, whereas suppression of microRNAs in males appeared to be dose-dependent. Select hippocampal microRNAs (such as miR-132-3p and miR-191-5p), previously shown to regulate dendrite morphology, were modulated by DEHP exposure in this study. The results suggest that DEHP exposure has the potential to regulate microRNAs in a sex-specific manner which may interfere with proper hippocampal development in males and preserve hippocampal development in females.
•Female CA3 neuron dendrites are resilient to DEHP-induced effects seen in males.•DEHP decreases male hippocampal microRNA levels & increases female microRNA levels.•DEHP lowers miR-132-3p, -191-5p levels in males, but levels increase in females.•MiR-132-3p, −191-5p have been previously shown to regulate dendrite development.•DEHP may affect dendrite morphology through sex-specific regulation of microRNAs. Previous studies have shown that di(2-ethylhexyl) phthalate (DEHP) exposure impairs the normal development of pre- and post-synaptic elements of the male, but not female, rat hippocampus. While males seem to be vulnerable to the neurodevelopmental deficits resulting from DEHP exposure, females appear to show a protective response. The purpose of the present study was to characterize hippocampal microRNAs in female and male rats exposed to DEHP to assess whether any patterns emerged that would be consistent with vulnerability in males and resilience in females. Male and female rats were treated with 0, 1, 10, or 20mg/kg of DEHP by intraperitoneal injections from postnatal day 16 (PND16) − PND22 and brains were removed and flash frozen on PND78. A group of 85 microRNAs which have been previously shown to play a role in the development and maintenance of hippocampal neurons was assessed with RT-qPCR. In response to DEHP exposure, there were 19 microRNAs that increased in females and 52 that decreased in males. The strongest microRNA response in females occurred in conjunction with the 10mg/kg of DEHP dose, whereas suppression of microRNAs in males appeared to be dose-dependent. Select hippocampal microRNAs (such as miR-132-3p and miR-191-5p), previously shown to regulate dendrite morphology, were modulated by DEHP exposure in this study. The results suggest that DEHP exposure has the potential to regulate microRNAs in a sex-specific manner which may interfere with proper hippocampal development in males and preserve hippocampal development in females.
Author Luu, Bryan E.
Holahan, Matthew R.
Storey, Kenneth B.
Childers, Christine L.
Green, Stuart R.
Author_xml – sequence: 1
  givenname: Bryan E.
  surname: Luu
  fullname: Luu, Bryan E.
  organization: Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
– sequence: 2
  givenname: Stuart R.
  surname: Green
  fullname: Green, Stuart R.
  organization: Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
– sequence: 3
  givenname: Christine L.
  surname: Childers
  fullname: Childers, Christine L.
  organization: Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
– sequence: 4
  givenname: Matthew R.
  surname: Holahan
  fullname: Holahan, Matthew R.
  organization: Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
– sequence: 5
  givenname: Kenneth B.
  surname: Storey
  fullname: Storey, Kenneth B.
  email: kenneth_storey@carleton.ca
  organization: Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28192093$$D View this record in MEDLINE/PubMed
BookMark eNp9kE1rFTEUhoO02NvqLxAk4MYuZkwyH0kWLkrRKpQWpIK7cJo5w-QyMxmTTOnd-dNN760uu8qBPO97OM8pOZr9jIS846zkjLeftuWMa_ClYFyWTJSM1a_IhispCi05PyKbTPFC8erXCTmNccsYb2SrX5MTobgWTFcb8uduQBr8iJH6ng5uWbyFaYGRTs4G_-PmIlI304Bx8XNEmjwFuyaki49phpRBfMzzGvZ_nfsoCkzDbhzwcTee02VIA4yQA7mlxwlGpDB3dD8ESPENOe5hjPj2-T0jP79-ubv8VlzfXn2_vLgubKVkKqywHdNKQyuZbpkCITmzbY1CKW4Zq6DR93XTVRK4thwAeMt6bBT0jehAV2fkw6F3Cf73ijGZrV_DnFcarutKtKquZKaqA5VvjzFgb5bgJgg7w5l5sm62Zm_dPFk3TJhsPafeP3ev9xN2_zP_NGfg8wHAfOGDw2CidThb7FxAm0zn3YsL_gLY2Jbt
CitedBy_id crossref_primary_10_1016_j_ecoenv_2019_02_043
crossref_primary_10_3390_ijerph19010574
crossref_primary_10_1016_j_envpol_2018_08_089
crossref_primary_10_1016_j_fct_2021_112592
crossref_primary_10_1016_j_taap_2023_116515
crossref_primary_10_1016_j_chemosphere_2018_10_040
crossref_primary_10_1016_j_reprotox_2022_10_001
crossref_primary_10_1002_tox_22540
crossref_primary_10_3389_fgene_2021_718796
crossref_primary_10_1002_jcp_29294
crossref_primary_10_1093_toxsci_kfy171
crossref_primary_10_2903_j_efsa_2019_5838
crossref_primary_10_1016_j_envint_2018_11_043
crossref_primary_10_1016_j_neuro_2018_10_013
crossref_primary_10_1136_jnnp_2020_322815
crossref_primary_10_1021_acschemneuro_0c00612
crossref_primary_10_1016_j_fct_2023_113888
crossref_primary_10_1021_acs_chemrestox_2c00257
crossref_primary_10_1159_000531669
crossref_primary_10_1016_j_toxrep_2021_07_014
Cites_doi 10.1371/journal.pone.0074907
10.1289/ehp.97105802
10.1111/j.1365-2605.2005.00567.x
10.1021/jf2020446
10.1111/j.1365-2605.2009.01019.x
10.1097/MOP.0b013e32835e1eb6
10.1016/j.ijheh.2011.01.009
10.1016/j.ab.2005.12.002
10.1016/j.neuroscience.2011.06.082
10.1523/JNEUROSCI.1054-09.2009
10.1371/journal.pone.0109522
10.1007/s11745-001-0798-1
10.1038/ncomms4263
10.1078/1438-4639-00270
10.1002/mnfr.201000121
10.1101/lm.1849910
10.1002/hipo.20242
10.1080/10937400903094091
10.7717/peerj.2436
10.1016/j.envres.2008.08.007
10.1016/j.bbadis.2011.02.002
10.1007/s00420-004-0570-x
10.1016/j.ijheh.2007.07.011
10.1182/blood-2006-01-030015
10.1038/nprot.2008.73
10.1016/j.brainres.2012.08.012
10.1038/srep04734
10.1289/ehp.7932
10.1146/annurev.publhealth.22.1.15
10.1016/j.tox.2006.03.015
10.1093/humrep/des069
10.3390/ijerph121013542
10.1016/j.toxlet.2014.06.002
10.1038/nrm3313
10.1186/gb-2002-3-7-research0034
10.1016/j.gene.2015.07.027
10.3390/ijerph110303156
10.1371/journal.pone.0025068
10.1262/jrd.16075
10.1016/S0014-5793(02)03406-3
10.1002/jat.2896
10.1073/pnas.1015691107
10.1542/peds.2006-3766
10.1093/brain/awr103
10.4161/cc.19790
10.1038/nature04367
10.1016/j.ab.2014.05.032
ContentType Journal Article
Copyright 2017 Elsevier B.V.
Copyright © 2017 Elsevier B.V. All rights reserved.
Copyright Elsevier BV Mar 2017
Copyright_xml – notice: 2017 Elsevier B.V.
– notice: Copyright © 2017 Elsevier B.V. All rights reserved.
– notice: Copyright Elsevier BV Mar 2017
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7TK
7U7
C1K
DOI 10.1016/j.neuro.2017.02.004
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Neurosciences Abstracts
Toxicology Abstracts
Environmental Sciences and Pollution Management
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Toxicology Abstracts
Neurosciences Abstracts
Environmental Sciences and Pollution Management
DatabaseTitleList Toxicology Abstracts
MEDLINE

Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1872-9711
EndPage 104
ExternalDocumentID 10_1016_j_neuro_2017_02_004
28192093
S0161813X17300244
Genre Journal Article
GroupedDBID ---
--K
--M
.GJ
.~1
0R~
123
1B1
1~.
1~5
29N
4.4
457
4G.
53G
5RE
5VS
7-5
71M
8P~
AACTN
AADPK
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AATCM
AAXLA
AAXUO
ABCQJ
ABFNM
ABFRF
ABFYP
ABJNI
ABLST
ABMAC
ABXDB
ABYKQ
ABZDS
ACDAQ
ACGFO
ACIUM
ACPRK
ACRLP
ADBBV
ADEZE
ADMUD
AEBSH
AEFWE
AEKER
AENEX
AFFNX
AFKWA
AFRAH
AFTJW
AFXIZ
AGHFR
AGUBO
AGWIK
AGYEJ
AHEUO
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AKIFW
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLECG
BLXMC
C45
CS3
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HVGLF
HZ~
IHE
J1W
KCYFY
KOM
M41
MO0
MOBAO
N9A
O-L
O9-
OAUVE
OGGZJ
OVD
OZT
P-8
P-9
P2P
PC.
PQQKQ
Q38
R2-
RIG
ROL
RPZ
SDF
SDG
SDP
SES
SPCBC
SSJ
SSN
SSP
SSZ
T5K
TEORI
TN5
UHS
UNMZH
XPP
ZGI
ZXP
~G-
~KM
AAXKI
AFJKZ
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
ACRPL
ADNMO
CITATION
7TK
7U7
C1K
ID FETCH-LOGICAL-c387t-c2cd0989a6709608a2710c64e2881c003a59b45d37a19c1aaa160fe58af52da93
IEDL.DBID AIKHN
ISSN 0161-813X
IngestDate Thu Oct 10 22:01:42 EDT 2024
Fri Dec 06 04:11:53 EST 2024
Wed Oct 16 00:57:10 EDT 2024
Fri Feb 23 02:27:44 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords Neurotoxicity
Plasticizer
Non-coding RNA
Gene regulation
Hippocampus
Dendrite
Language English
License Copyright © 2017 Elsevier B.V. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c387t-c2cd0989a6709608a2710c64e2881c003a59b45d37a19c1aaa160fe58af52da93
PMID 28192093
PQID 1943268437
PQPubID 105584
PageCount 7
ParticipantIDs proquest_journals_1943268437
crossref_primary_10_1016_j_neuro_2017_02_004
pubmed_primary_28192093
elsevier_sciencedirect_doi_10_1016_j_neuro_2017_02_004
PublicationCentury 2000
PublicationDate March 2017
2017-Mar
2017-03-00
20170301
PublicationDateYYYYMMDD 2017-03-01
PublicationDate_xml – month: 03
  year: 2017
  text: March 2017
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
– name: Redfield
PublicationTitle Neurotoxicology (Park Forest South)
PublicationTitleAlternate Neurotoxicology
PublicationYear 2017
Publisher Elsevier B.V
Elsevier BV
Publisher_xml – name: Elsevier B.V
– name: Elsevier BV
References Smith, MacDonald, Holahan (bib0195) 2011; 193
Hu, Yu, Gu, Yang, Tu, Zhu, Li (bib0095) 2014; 5
Li, Jiang, Sun, Zhang, Tan, Yu, Tan (bib0125) 2014; 4
Koch, Wittassek, Brüning, Angerer, Heudorf (bib0120) 2011; 214
Swan (bib0210) 2008; 108
Hong, Ji, Choi, Manabe, Jeung (bib0090) 2005; 51
Schettler, Skakkebæk, De Kretser, Leffers (bib0170) 2006
Pellissier, Glogowski, Heinemann, Ballivet, Ossipow (bib0145) 2006; 350
Anderson, Spencer-Smith, Wood (bib0010) 2011
Smith, Farmer, Lee, Holahan, Smith (bib0200) 2015; 12
Keeley, Wartman, Häusler, Holahan (bib0105) 2010; 17
Wittassek, Koch, Angerer, Brüning (bib0235) 2011
Zhang, Storey (bib0240) 2016; 4
Vandesompele, De Preter, Pattyn, Poppe, Van Roy, De Paepe, Speleman (bib0225) 2002; 3
Uauy, Hoffman, Peirano, Birch, Birch (bib0215) 2001; 36
Biggar, Wu, Storey (bib0025) 2014; 462
Chen, Xu, Tan, Lee, Cheng, Lee, Xu, Ho (bib0050) 2014; 11
Smith, Holahan (bib0190) 2014; 9
Wartman, Gervais, Smith, Comba, Mumby, Holahan (bib0230) 2012; 1475
An, Cai, Che, Yu, Cao, Liu, Zhao, Jing, Shen, Liu, Du, Chen, Luo (bib0005) 2014; 229
Magill, Cambronne, Luikart, Lioy, Leighton, Westbrook, Mandel, Goodman (bib0140) 2010; 107
Biggar, Storey (bib0020) 2012; 11
Schmittgen, Livak (bib0175) 2008; 3
Saillenfait, Sabaté, Robert, Rouiller-Fabre, Roudot, Moison, Denis (bib0160) 2013; 33
Eacker, Keuss, Berezikov, Dawson, Dawson (bib0065) 2011; 6
Shivdasani (bib0185) 2006
Jagasia, Steib, Englberger, Herold, Faus-Kessler, Saxe, Gage, Song, Lie (bib0100) 2009; 29
Swan, Liu, Hines, Kruse, Wang, Redmon, Sparks, Weiss (bib0205) 2010
Koch, Preuss, Drexler, Angerer (bib0115) 2005; 78
Bueno, Malumbres (bib0040) 2011
Arain, Haque, Johal, Mathur, Nel, Rais, Sandhu, Sharma (bib0015) 2013
Koch, Drexler, Angerer (bib0110) 2004; 207
Ramstedt, Slotte (bib0150) 2002
Heudorf, Mersch-Sundermann, Angerer (bib0080) 2007; 210
Braun, Sathyanarayana, Hauser (bib0035) 2013; 25
Schratt, Tuebing, Nigh, Kane, Sabatini, Kiebler, Greenberg (bib0180) 2006; 439
Sathyanarayana, Karr, Lozano, Brown, Calafat, Liu, Swan (bib0165) 2008; 121
Van Spronsen, van Battum, Kuijpers, Vangoor, Rietman, Pothof, Gumy, van IJcken, Akhmanova, Pasterkamp, Hoogenraad (bib0220) 2013; 8
Borch, Metzdorff, Vinggaard, Brokken, Dalgaard (bib0030) 2006; 223
Cirillo, Fasano, Castaldi, Montuori, Amodio Cocchieri (bib0055) 2011; 59
Green, Hauser, Calafat, Weuve, Schettler, Ringer, Huttner, Hu (bib0070) 2005; 113
Lyche, Gutleb, Bergman, Eriksen, Murk, Ropstad, Saunders, Skaare (bib0135) 2009; 12
Luu, Storey (bib0130) 2015; 573
Harris, Henttu, Parker, Sumpter (bib0075) 1997; 105
Holahan, Honegger, Routtenberg (bib0085) 2007; 17
Calabrese, Baldwin (bib0045) 2001; 22
Desdoits-Lethimonier, Albert, Le Bizec, Perdu, Zalko, Courant, Lesné, Guillé, Dejucq-Rainsford, Jégou (bib0060) 2012; 27
Rottiers, Näär (bib0155) 2012; 13
Magill (10.1016/j.neuro.2017.02.004_bib0140) 2010; 107
Swan (10.1016/j.neuro.2017.02.004_bib0205) 2010
Green (10.1016/j.neuro.2017.02.004_bib0070) 2005; 113
Schettler (10.1016/j.neuro.2017.02.004_bib0170) 2006
Keeley (10.1016/j.neuro.2017.02.004_bib0105) 2010; 17
Harris (10.1016/j.neuro.2017.02.004_bib0075) 1997; 105
Hong (10.1016/j.neuro.2017.02.004_bib0090) 2005; 51
Ramstedt (10.1016/j.neuro.2017.02.004_bib0150) 2002
Holahan (10.1016/j.neuro.2017.02.004_bib0085) 2007; 17
Koch (10.1016/j.neuro.2017.02.004_bib0110) 2004; 207
Anderson (10.1016/j.neuro.2017.02.004_bib0010) 2011
Bueno (10.1016/j.neuro.2017.02.004_bib0040) 2011
Biggar (10.1016/j.neuro.2017.02.004_bib0020) 2012; 11
Calabrese (10.1016/j.neuro.2017.02.004_bib0045) 2001; 22
Li (10.1016/j.neuro.2017.02.004_bib0125) 2014; 4
Koch (10.1016/j.neuro.2017.02.004_bib0115) 2005; 78
Shivdasani (10.1016/j.neuro.2017.02.004_bib0185) 2006
Smith (10.1016/j.neuro.2017.02.004_bib0190) 2014; 9
Schmittgen (10.1016/j.neuro.2017.02.004_bib0175) 2008; 3
Sathyanarayana (10.1016/j.neuro.2017.02.004_bib0165) 2008; 121
Uauy (10.1016/j.neuro.2017.02.004_bib0215) 2001; 36
Vandesompele (10.1016/j.neuro.2017.02.004_bib0225) 2002; 3
Luu (10.1016/j.neuro.2017.02.004_bib0130) 2015; 573
Cirillo (10.1016/j.neuro.2017.02.004_bib0055) 2011; 59
Jagasia (10.1016/j.neuro.2017.02.004_bib0100) 2009; 29
Smith (10.1016/j.neuro.2017.02.004_bib0195) 2011; 193
Swan (10.1016/j.neuro.2017.02.004_bib0210) 2008; 108
Heudorf (10.1016/j.neuro.2017.02.004_bib0080) 2007; 210
Chen (10.1016/j.neuro.2017.02.004_bib0050) 2014; 11
Wittassek (10.1016/j.neuro.2017.02.004_bib0235) 2011
Van Spronsen (10.1016/j.neuro.2017.02.004_bib0220) 2013; 8
Pellissier (10.1016/j.neuro.2017.02.004_bib0145) 2006; 350
Arain (10.1016/j.neuro.2017.02.004_bib0015) 2013
Borch (10.1016/j.neuro.2017.02.004_bib0030) 2006; 223
Smith (10.1016/j.neuro.2017.02.004_bib0200) 2015; 12
Zhang (10.1016/j.neuro.2017.02.004_bib0240) 2016; 4
Saillenfait (10.1016/j.neuro.2017.02.004_bib0160) 2013; 33
Braun (10.1016/j.neuro.2017.02.004_bib0035) 2013; 25
Lyche (10.1016/j.neuro.2017.02.004_bib0135) 2009; 12
Schratt (10.1016/j.neuro.2017.02.004_bib0180) 2006; 439
Wartman (10.1016/j.neuro.2017.02.004_bib0230) 2012; 1475
Eacker (10.1016/j.neuro.2017.02.004_bib0065) 2011; 6
Hu (10.1016/j.neuro.2017.02.004_bib0095) 2014; 5
Koch (10.1016/j.neuro.2017.02.004_bib0120) 2011; 214
An (10.1016/j.neuro.2017.02.004_bib0005) 2014; 229
Rottiers (10.1016/j.neuro.2017.02.004_bib0155) 2012; 13
Biggar (10.1016/j.neuro.2017.02.004_bib0025) 2014; 462
Desdoits-Lethimonier (10.1016/j.neuro.2017.02.004_bib0060) 2012; 27
References_xml – volume: 210
  start-page: 623
  year: 2007
  end-page: 634
  ident: bib0080
  article-title: Phthalates: toxicology and exposure
  publication-title: Int. J. Hyg. Environ. Health
  contributor:
    fullname: Angerer
– volume: 25
  start-page: 247
  year: 2013
  end-page: 254
  ident: bib0035
  article-title: Phthalate exposure and children's health
  publication-title: Curr. Opin. Pediatr.
  contributor:
    fullname: Hauser
– volume: 11
  start-page: 1705
  year: 2012
  end-page: 1713
  ident: bib0020
  article-title: Evidence for cell cycle suppression and microRNA regulation of cyclin D1 during anoxia exposure in turtles
  publication-title: ABBV Cell Cycle
  contributor:
    fullname: Storey
– volume: 214
  start-page: 188
  year: 2011
  end-page: 195
  ident: bib0120
  article-title: Exposure to phthalates in 5–6 years old primary school starters in Germany-A human biomonitoring study and a cumulative risk assessment
  publication-title: Int. J. Hyg. Environ. Health
  contributor:
    fullname: Heudorf
– volume: 29
  start-page: 7966
  year: 2009
  end-page: 7977
  ident: bib0100
  article-title: GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus
  publication-title: J. Neurosci.
  contributor:
    fullname: Lie
– start-page: 134
  year: 2006
  end-page: 139
  ident: bib0170
  article-title: Human exposure to phthalates via consumer products
  publication-title: Int. J. Androl.
  contributor:
    fullname: Leffers
– volume: 36
  start-page: 885
  year: 2001
  end-page: 895
  ident: bib0215
  article-title: Essential fatty acids in visual and brain development
  publication-title: Lipids
  contributor:
    fullname: Birch
– year: 2013
  ident: bib0015
  article-title: Maturation of the adolescent brain
  publication-title: Neuropsychiatr. Dis. Treat.
  contributor:
    fullname: Sharma
– volume: 223
  start-page: 144
  year: 2006
  end-page: 155
  ident: bib0030
  article-title: Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis
  publication-title: Toxicology
  contributor:
    fullname: Dalgaard
– volume: 13
  start-page: 239
  year: 2012
  end-page: 250
  ident: bib0155
  article-title: MicroRNAs in metabolism and metabolic disorders
  publication-title: Nat. Rev. Mol. Cell Biol.
  contributor:
    fullname: Näär
– volume: 4
  start-page: 4734
  year: 2014
  ident: bib0125
  article-title: Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy
  publication-title: Sci. Rep.
  contributor:
    fullname: Tan
– volume: 3
  start-page: 1101
  year: 2008
  end-page: 1108
  ident: bib0175
  article-title: Analyzing real-time PCR data by the comparative CT method
  publication-title: Nat. Protoc.
  contributor:
    fullname: Livak
– volume: 5
  start-page: 3263
  year: 2014
  ident: bib0095
  article-title: miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression
  publication-title: Nat. Commun.
  contributor:
    fullname: Li
– year: 2011
  ident: bib0040
  article-title: MicroRNAs and the cell cycle
  publication-title: Biochim. Biophys. Acta − Mol. Basis Dis.
  contributor:
    fullname: Malumbres
– volume: 108
  start-page: 177
  year: 2008
  end-page: 184
  ident: bib0210
  article-title: Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
  publication-title: Environ. Res.
  contributor:
    fullname: Swan
– volume: 27
  start-page: 1451
  year: 2012
  end-page: 1459
  ident: bib0060
  article-title: Human testis steroidogenesis is inhibited by phthalates
  publication-title: Hum. Reprod.
  contributor:
    fullname: Jégou
– volume: 573
  start-page: 64
  year: 2015
  end-page: 69
  ident: bib0130
  article-title: Dehydration triggers differential microRNA expression in Xenopus laevis brain
  publication-title: Gene
  contributor:
    fullname: Storey
– volume: 11
  start-page: 3156
  year: 2014
  end-page: 3168
  ident: bib0050
  article-title: Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures
  publication-title: Int. J. Environ. Res. Public Health
  contributor:
    fullname: Ho
– year: 2002
  ident: bib0150
  article-title: Membrane properties of sphingomyelins
  publication-title: FEBS Lett.
  contributor:
    fullname: Slotte
– volume: 22
  start-page: 15
  year: 2001
  end-page: 33
  ident: bib0045
  article-title: U-Shaped Dose-Responses in Biology, Toxicology, and Public Health
  publication-title: Annu. Rev. Public Health
  contributor:
    fullname: Baldwin
– start-page: 259
  year: 2010
  end-page: 267
  ident: bib0205
  article-title: Prenatal phthalate exposure and reduced masculine play in boys
  publication-title: Int. J. Androl.
  contributor:
    fullname: Weiss
– volume: 59
  start-page: 10532
  year: 2011
  end-page: 10538
  ident: bib0055
  article-title: Children’s exposure to Di(2-ethylhexyl)phthalate and dibutylphthalate plasticizers from school meals
  publication-title: J. Agric. Food Chem.
  contributor:
    fullname: Amodio Cocchieri
– volume: 17
  start-page: 58
  year: 2007
  end-page: 67
  ident: bib0085
  article-title: Expansion and retraction of hippocampal mossy fibers during postweaning development: strain-specific effects of NMDA receptor blockade
  publication-title: Hippocampus
  contributor:
    fullname: Routtenberg
– volume: 51
  start-page: 253
  year: 2005
  end-page: 263
  ident: bib0090
  article-title: Conflict of estrogenic activity by various phthalates between in vitro and in vivo models related to the expression of Calbindin-D9k
  publication-title: J. Reprod. Dev.
  contributor:
    fullname: Jeung
– volume: 33
  start-page: 1027
  year: 2013
  end-page: 1035
  ident: bib0160
  article-title: Dose-dependent alterations in gene expression and testosterone production in fetal rat testis after exposure to di-n-hexyl phthalate
  publication-title: J. Appl. Toxicol.
  contributor:
    fullname: Denis
– volume: 439
  start-page: 283
  year: 2006
  end-page: 289
  ident: bib0180
  article-title: A brain-specific microRNA regulates dendritic spine development
  publication-title: Nature
  contributor:
    fullname: Greenberg
– volume: 12
  start-page: 13542
  year: 2015
  end-page: 13559
  ident: bib0200
  article-title: Altered hippocampal lipid profile following acute postnatal exposure to Di(2-Ethylhexyl) phthalate in rats
  publication-title: Int. J. Environ. Res. Public Health
  contributor:
    fullname: Smith
– volume: 113
  start-page: 1222
  year: 2005
  end-page: 1225
  ident: bib0070
  article-title: Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants
  publication-title: Environ. Health Perspect.
  contributor:
    fullname: Hu
– volume: 8
  year: 2013
  ident: bib0220
  article-title: Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures
  publication-title: PLoS One
  contributor:
    fullname: Hoogenraad
– volume: 105
  start-page: 802
  year: 1997
  end-page: 811
  ident: bib0075
  article-title: The estrogenic activity of phthalate esters in vitro
  publication-title: Environ. Health Perspect.
  contributor:
    fullname: Sumpter
– volume: 207
  start-page: 15
  year: 2004
  end-page: 22
  ident: bib0110
  article-title: Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP)
  publication-title: Int. J. Hyg. Environ. Health
  contributor:
    fullname: Angerer
– volume: 78
  start-page: 223
  year: 2005
  end-page: 229
  ident: bib0115
  article-title: Exposure of nursery school children and their parents and teachers to di-n-butylphthalate and butylbenzylphthalate
  publication-title: Int. Arch. Occup. Environ. Heal.
  contributor:
    fullname: Angerer
– year: 2006
  ident: bib0185
  article-title: MicroRNAs: regulators of gene expression and cell differentiation
  publication-title: Blood
  contributor:
    fullname: Shivdasani
– volume: 193
  start-page: 100
  year: 2011
  end-page: 108
  ident: bib0195
  article-title: Acute postnatal exposure to di(2-ethylhexyl) phthalate adversely impacts hippocampal development in the male rat
  publication-title: Neuroscience
  contributor:
    fullname: Holahan
– volume: 3
  year: 2002
  ident: bib0225
  article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
  publication-title: Genome Biol.
  contributor:
    fullname: Speleman
– volume: 1475
  start-page: 37
  year: 2012
  end-page: 48
  ident: bib0230
  article-title: Enhanced adolescent learning and hippocampal axonal projections following preadolescent spatial exposure to a water or dry maze
  publication-title: Brain Res.
  contributor:
    fullname: Holahan
– volume: 17
  start-page: 344
  year: 2010
  end-page: 354
  ident: bib0105
  article-title: Effect of juvenile pretraining on adolescent structural hippocampal attributes as a substrate for enhanced spatial performance
  publication-title: Learn. Mem.
  contributor:
    fullname: Holahan
– volume: 350
  start-page: 310
  year: 2006
  end-page: 312
  ident: bib0145
  article-title: Lab assembly of a low-cost, robust SYBR green buffer system for quantitative real-time polymerase chain reaction
  publication-title: Anal. Biochem.
  contributor:
    fullname: Ossipow
– volume: 4
  start-page: e2436
  year: 2016
  ident: bib0240
  article-title: RBioplot: an easy-to-use R pipeline for automated statistical analysis and data visualization in molecular biology and biochemistry
  publication-title: PeerJ
  contributor:
    fullname: Storey
– volume: 462
  start-page: 32
  year: 2014
  end-page: 34
  ident: bib0025
  article-title: High-throughput amplification of mature microRNAs in uncharacterized animal models using polyadenylated RNA and stem-loop reverse transcription polymerase chain reaction
  publication-title: Anal. Biochem.
  contributor:
    fullname: Storey
– year: 2011
  ident: bib0235
  article-title: Assessing exposure to phthalates − The human biomonitoring approach
  publication-title: Mol. Nutr. Food Res.
  contributor:
    fullname: Brüning
– volume: 121
  start-page: e260
  year: 2008
  end-page: e268
  ident: bib0165
  article-title: Baby care products: possible sources of infant phthalate exposure
  publication-title: Pediatrics
  contributor:
    fullname: Swan
– volume: 229
  start-page: 158
  year: 2014
  end-page: 166
  ident: bib0005
  article-title: The changes of miRNA expression in rat hippocampus following chronic lead exposure
  publication-title: Toxicol. Lett.
  contributor:
    fullname: Luo
– year: 2011
  ident: bib0010
  article-title: Do children really recover better? Neurobehavioural plasticity after early brain insult
  publication-title: Brain
  contributor:
    fullname: Wood
– volume: 6
  year: 2011
  ident: bib0065
  article-title: Neuronal activity regulates hippocampal miRNA expression
  publication-title: PLoS One
  contributor:
    fullname: Dawson
– volume: 9
  year: 2014
  ident: bib0190
  article-title: Reduced hippocampal dendritic spine density and BDNF expression following acute postnatal exposure to Di(2-Ethylhexyl) phthalate in male long evans rats
  publication-title: PLoS One
  contributor:
    fullname: Holahan
– volume: 107
  start-page: 20382
  year: 2010
  end-page: 20387
  ident: bib0140
  article-title: microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Goodman
– volume: 12
  start-page: 225
  year: 2009
  end-page: 249
  ident: bib0135
  article-title: Reproductive and developmental toxicity of phthalates
  publication-title: J. Toxicol. Environ. Health. B Crit. Rev.
  contributor:
    fullname: Skaare
– volume: 8
  year: 2013
  ident: 10.1016/j.neuro.2017.02.004_bib0220
  article-title: Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0074907
  contributor:
    fullname: Van Spronsen
– volume: 105
  start-page: 802
  year: 1997
  ident: 10.1016/j.neuro.2017.02.004_bib0075
  article-title: The estrogenic activity of phthalate esters in vitro
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.97105802
  contributor:
    fullname: Harris
– start-page: 134
  year: 2006
  ident: 10.1016/j.neuro.2017.02.004_bib0170
  article-title: Human exposure to phthalates via consumer products
  publication-title: Int. J. Androl.
  doi: 10.1111/j.1365-2605.2005.00567.x
  contributor:
    fullname: Schettler
– volume: 59
  start-page: 10532
  year: 2011
  ident: 10.1016/j.neuro.2017.02.004_bib0055
  article-title: Children’s exposure to Di(2-ethylhexyl)phthalate and dibutylphthalate plasticizers from school meals
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf2020446
  contributor:
    fullname: Cirillo
– year: 2013
  ident: 10.1016/j.neuro.2017.02.004_bib0015
  article-title: Maturation of the adolescent brain
  publication-title: Neuropsychiatr. Dis. Treat.
  contributor:
    fullname: Arain
– start-page: 259
  year: 2010
  ident: 10.1016/j.neuro.2017.02.004_bib0205
  article-title: Prenatal phthalate exposure and reduced masculine play in boys
  publication-title: Int. J. Androl.
  doi: 10.1111/j.1365-2605.2009.01019.x
  contributor:
    fullname: Swan
– volume: 25
  start-page: 247
  year: 2013
  ident: 10.1016/j.neuro.2017.02.004_bib0035
  article-title: Phthalate exposure and children's health
  publication-title: Curr. Opin. Pediatr.
  doi: 10.1097/MOP.0b013e32835e1eb6
  contributor:
    fullname: Braun
– volume: 214
  start-page: 188
  year: 2011
  ident: 10.1016/j.neuro.2017.02.004_bib0120
  article-title: Exposure to phthalates in 5–6 years old primary school starters in Germany-A human biomonitoring study and a cumulative risk assessment
  publication-title: Int. J. Hyg. Environ. Health
  doi: 10.1016/j.ijheh.2011.01.009
  contributor:
    fullname: Koch
– volume: 350
  start-page: 310
  year: 2006
  ident: 10.1016/j.neuro.2017.02.004_bib0145
  article-title: Lab assembly of a low-cost, robust SYBR green buffer system for quantitative real-time polymerase chain reaction
  publication-title: Anal. Biochem.
  doi: 10.1016/j.ab.2005.12.002
  contributor:
    fullname: Pellissier
– volume: 193
  start-page: 100
  year: 2011
  ident: 10.1016/j.neuro.2017.02.004_bib0195
  article-title: Acute postnatal exposure to di(2-ethylhexyl) phthalate adversely impacts hippocampal development in the male rat
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2011.06.082
  contributor:
    fullname: Smith
– volume: 29
  start-page: 7966
  year: 2009
  ident: 10.1016/j.neuro.2017.02.004_bib0100
  article-title: GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1054-09.2009
  contributor:
    fullname: Jagasia
– volume: 9
  year: 2014
  ident: 10.1016/j.neuro.2017.02.004_bib0190
  article-title: Reduced hippocampal dendritic spine density and BDNF expression following acute postnatal exposure to Di(2-Ethylhexyl) phthalate in male long evans rats
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0109522
  contributor:
    fullname: Smith
– volume: 36
  start-page: 885
  year: 2001
  ident: 10.1016/j.neuro.2017.02.004_bib0215
  article-title: Essential fatty acids in visual and brain development
  publication-title: Lipids
  doi: 10.1007/s11745-001-0798-1
  contributor:
    fullname: Uauy
– volume: 5
  start-page: 3263
  year: 2014
  ident: 10.1016/j.neuro.2017.02.004_bib0095
  article-title: miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms4263
  contributor:
    fullname: Hu
– volume: 207
  start-page: 15
  year: 2004
  ident: 10.1016/j.neuro.2017.02.004_bib0110
  article-title: Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP)
  publication-title: Int. J. Hyg. Environ. Health
  doi: 10.1078/1438-4639-00270
  contributor:
    fullname: Koch
– year: 2011
  ident: 10.1016/j.neuro.2017.02.004_bib0235
  article-title: Assessing exposure to phthalates − The human biomonitoring approach
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.201000121
  contributor:
    fullname: Wittassek
– volume: 17
  start-page: 344
  year: 2010
  ident: 10.1016/j.neuro.2017.02.004_bib0105
  article-title: Effect of juvenile pretraining on adolescent structural hippocampal attributes as a substrate for enhanced spatial performance
  publication-title: Learn. Mem.
  doi: 10.1101/lm.1849910
  contributor:
    fullname: Keeley
– volume: 17
  start-page: 58
  year: 2007
  ident: 10.1016/j.neuro.2017.02.004_bib0085
  article-title: Expansion and retraction of hippocampal mossy fibers during postweaning development: strain-specific effects of NMDA receptor blockade
  publication-title: Hippocampus
  doi: 10.1002/hipo.20242
  contributor:
    fullname: Holahan
– volume: 12
  start-page: 225
  year: 2009
  ident: 10.1016/j.neuro.2017.02.004_bib0135
  article-title: Reproductive and developmental toxicity of phthalates
  publication-title: J. Toxicol. Environ. Health. B Crit. Rev.
  doi: 10.1080/10937400903094091
  contributor:
    fullname: Lyche
– volume: 4
  start-page: e2436
  year: 2016
  ident: 10.1016/j.neuro.2017.02.004_bib0240
  article-title: RBioplot: an easy-to-use R pipeline for automated statistical analysis and data visualization in molecular biology and biochemistry
  publication-title: PeerJ
  doi: 10.7717/peerj.2436
  contributor:
    fullname: Zhang
– volume: 108
  start-page: 177
  year: 2008
  ident: 10.1016/j.neuro.2017.02.004_bib0210
  article-title: Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
  publication-title: Environ. Res.
  doi: 10.1016/j.envres.2008.08.007
  contributor:
    fullname: Swan
– year: 2011
  ident: 10.1016/j.neuro.2017.02.004_bib0040
  article-title: MicroRNAs and the cell cycle
  publication-title: Biochim. Biophys. Acta − Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2011.02.002
  contributor:
    fullname: Bueno
– volume: 78
  start-page: 223
  year: 2005
  ident: 10.1016/j.neuro.2017.02.004_bib0115
  article-title: Exposure of nursery school children and their parents and teachers to di-n-butylphthalate and butylbenzylphthalate
  publication-title: Int. Arch. Occup. Environ. Heal.
  doi: 10.1007/s00420-004-0570-x
  contributor:
    fullname: Koch
– volume: 210
  start-page: 623
  year: 2007
  ident: 10.1016/j.neuro.2017.02.004_bib0080
  article-title: Phthalates: toxicology and exposure
  publication-title: Int. J. Hyg. Environ. Health
  doi: 10.1016/j.ijheh.2007.07.011
  contributor:
    fullname: Heudorf
– year: 2006
  ident: 10.1016/j.neuro.2017.02.004_bib0185
  article-title: MicroRNAs: regulators of gene expression and cell differentiation
  publication-title: Blood
  doi: 10.1182/blood-2006-01-030015
  contributor:
    fullname: Shivdasani
– volume: 3
  start-page: 1101
  year: 2008
  ident: 10.1016/j.neuro.2017.02.004_bib0175
  article-title: Analyzing real-time PCR data by the comparative CT method
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.73
  contributor:
    fullname: Schmittgen
– volume: 1475
  start-page: 37
  year: 2012
  ident: 10.1016/j.neuro.2017.02.004_bib0230
  article-title: Enhanced adolescent learning and hippocampal axonal projections following preadolescent spatial exposure to a water or dry maze
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2012.08.012
  contributor:
    fullname: Wartman
– volume: 4
  start-page: 4734
  year: 2014
  ident: 10.1016/j.neuro.2017.02.004_bib0125
  article-title: Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy
  publication-title: Sci. Rep.
  doi: 10.1038/srep04734
  contributor:
    fullname: Li
– volume: 113
  start-page: 1222
  year: 2005
  ident: 10.1016/j.neuro.2017.02.004_bib0070
  article-title: Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.7932
  contributor:
    fullname: Green
– volume: 22
  start-page: 15
  year: 2001
  ident: 10.1016/j.neuro.2017.02.004_bib0045
  article-title: U-Shaped Dose-Responses in Biology, Toxicology, and Public Health 1
  publication-title: Annu. Rev. Public Health
  doi: 10.1146/annurev.publhealth.22.1.15
  contributor:
    fullname: Calabrese
– volume: 223
  start-page: 144
  year: 2006
  ident: 10.1016/j.neuro.2017.02.004_bib0030
  article-title: Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis
  publication-title: Toxicology
  doi: 10.1016/j.tox.2006.03.015
  contributor:
    fullname: Borch
– volume: 27
  start-page: 1451
  year: 2012
  ident: 10.1016/j.neuro.2017.02.004_bib0060
  article-title: Human testis steroidogenesis is inhibited by phthalates
  publication-title: Hum. Reprod.
  doi: 10.1093/humrep/des069
  contributor:
    fullname: Desdoits-Lethimonier
– volume: 12
  start-page: 13542
  year: 2015
  ident: 10.1016/j.neuro.2017.02.004_bib0200
  article-title: Altered hippocampal lipid profile following acute postnatal exposure to Di(2-Ethylhexyl) phthalate in rats
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph121013542
  contributor:
    fullname: Smith
– volume: 229
  start-page: 158
  year: 2014
  ident: 10.1016/j.neuro.2017.02.004_bib0005
  article-title: The changes of miRNA expression in rat hippocampus following chronic lead exposure
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2014.06.002
  contributor:
    fullname: An
– volume: 13
  start-page: 239
  year: 2012
  ident: 10.1016/j.neuro.2017.02.004_bib0155
  article-title: MicroRNAs in metabolism and metabolic disorders
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3313
  contributor:
    fullname: Rottiers
– volume: 3
  year: 2002
  ident: 10.1016/j.neuro.2017.02.004_bib0225
  article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
  publication-title: Genome Biol.
  doi: 10.1186/gb-2002-3-7-research0034
  contributor:
    fullname: Vandesompele
– volume: 573
  start-page: 64
  year: 2015
  ident: 10.1016/j.neuro.2017.02.004_bib0130
  article-title: Dehydration triggers differential microRNA expression in Xenopus laevis brain
  publication-title: Gene
  doi: 10.1016/j.gene.2015.07.027
  contributor:
    fullname: Luu
– volume: 11
  start-page: 3156
  year: 2014
  ident: 10.1016/j.neuro.2017.02.004_bib0050
  article-title: Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph110303156
  contributor:
    fullname: Chen
– volume: 6
  year: 2011
  ident: 10.1016/j.neuro.2017.02.004_bib0065
  article-title: Neuronal activity regulates hippocampal miRNA expression
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0025068
  contributor:
    fullname: Eacker
– volume: 51
  start-page: 253
  year: 2005
  ident: 10.1016/j.neuro.2017.02.004_bib0090
  article-title: Conflict of estrogenic activity by various phthalates between in vitro and in vivo models related to the expression of Calbindin-D9k
  publication-title: J. Reprod. Dev.
  doi: 10.1262/jrd.16075
  contributor:
    fullname: Hong
– year: 2002
  ident: 10.1016/j.neuro.2017.02.004_bib0150
  article-title: Membrane properties of sphingomyelins
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(02)03406-3
  contributor:
    fullname: Ramstedt
– volume: 33
  start-page: 1027
  year: 2013
  ident: 10.1016/j.neuro.2017.02.004_bib0160
  article-title: Dose-dependent alterations in gene expression and testosterone production in fetal rat testis after exposure to di-n-hexyl phthalate
  publication-title: J. Appl. Toxicol.
  doi: 10.1002/jat.2896
  contributor:
    fullname: Saillenfait
– volume: 107
  start-page: 20382
  year: 2010
  ident: 10.1016/j.neuro.2017.02.004_bib0140
  article-title: microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1015691107
  contributor:
    fullname: Magill
– volume: 121
  start-page: e260
  year: 2008
  ident: 10.1016/j.neuro.2017.02.004_bib0165
  article-title: Baby care products: possible sources of infant phthalate exposure
  publication-title: Pediatrics
  doi: 10.1542/peds.2006-3766
  contributor:
    fullname: Sathyanarayana
– year: 2011
  ident: 10.1016/j.neuro.2017.02.004_bib0010
  article-title: Do children really recover better? Neurobehavioural plasticity after early brain insult
  publication-title: Brain
  doi: 10.1093/brain/awr103
  contributor:
    fullname: Anderson
– volume: 11
  start-page: 1705
  year: 2012
  ident: 10.1016/j.neuro.2017.02.004_bib0020
  article-title: Evidence for cell cycle suppression and microRNA regulation of cyclin D1 during anoxia exposure in turtles
  publication-title: ABBV Cell Cycle
  doi: 10.4161/cc.19790
  contributor:
    fullname: Biggar
– volume: 439
  start-page: 283
  year: 2006
  ident: 10.1016/j.neuro.2017.02.004_bib0180
  article-title: A brain-specific microRNA regulates dendritic spine development
  publication-title: Nature
  doi: 10.1038/nature04367
  contributor:
    fullname: Schratt
– volume: 462
  start-page: 32
  year: 2014
  ident: 10.1016/j.neuro.2017.02.004_bib0025
  article-title: High-throughput amplification of mature microRNAs in uncharacterized animal models using polyadenylated RNA and stem-loop reverse transcription polymerase chain reaction
  publication-title: Anal. Biochem.
  doi: 10.1016/j.ab.2014.05.032
  contributor:
    fullname: Biggar
SSID ssj0015769
Score 2.3499339
Snippet •Female CA3 neuron dendrites are resilient to DEHP-induced effects seen in males.•DEHP decreases male hippocampal microRNA levels & increases female microRNA...
Previous studies have shown that di(2-ethylhexyl) phthalate (DEHP) exposure impairs the normal development of pre- and post-synaptic elements of the male, but...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 98
SubjectTerms Age Factors
Animals
Brain
Dendrite
Dendritic structure
Diethylhexyl Phthalate - pharmacology
Dose-Response Relationship, Drug
Exposure
Female
Females
Gene Expression Regulation, Developmental - drug effects
Gene regulation
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Humans
Infant, Newborn
Male
Males
MicroRNAs - metabolism
miRNA
Neurotoxicity
Non-coding RNA
Plasticizer
Plasticizers - pharmacology
Rats
Ribonucleic acid
RNA
Rodents
Sex Characteristics
Title The roles of hippocampal microRNAs in response to acute postnatal exposure to di(2-ethylhexyl) phthalate in female and male rats
URI https://dx.doi.org/10.1016/j.neuro.2017.02.004
https://www.ncbi.nlm.nih.gov/pubmed/28192093
https://www.proquest.com/docview/1943268437
Volume 59
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LitswFBXzgNJN6bvTToMWXbRQNZYly9YyhA7pY0KZdiA7cS3LxEPGMbED003pp_dKtge6mC668wPZQudK9-B7fETIGxXnMaRcs0zJiEkBjgGmaZZCnqgyF8oFVeX5Ui0u5edVsjog8_FfGC-rHNb-fk0Pq_VwZTqM5rSpqun34PXOxYp7y3XMUofkGNORr9Uezz59WSxviwlIqXVv8c2ZbzCaDwWZV7CN9BKvtPfulHclqLsIaEhEZw_Jg4FB0lnfyUfkwNWPyb3zoUb-hPxG5KkXDbZ0W9J11TSYrnDSb-i1F99dLGctrWq668WxjnZbCnbfOdps2672X3Oou8Hj_S7cK6q3MXMI52btbn5u3tFm3a1hgxTVP6V015hhKNQFDQcYT-1Tcnn28cd8wYZ9FpgVWdoxG9si0pkG7-WmogxipB1WSRdnGbc47SHRuUwKkQLXlgMAV1HpkgzKJC5Ai2fkqN7W7gWhfufyRIFF4iElEnfIpE2ElkXO_T6V6Ql5Pw6uaXo7DTPqzK5MwMJ4LEwUG8TihKgRAPNXVBhc8P_d8HSEywyTsjVcS-HNbQR243kP4W0nfD0xjrR4-b9vfEXu-7NennZKjrrd3r1GvtLlE3L44RefYFTOL75-mwzR-QeOiOoJ
link.rule.ids 314,780,784,4502,24116,27924,27925,45585,45679
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFLVKkaAbxLstLXjBAiTMxM_Ey6pqNUBnFtBKs7Mcx9EETTPRJCO1G8Snc-0klViUBTsrT8vn-t6j-OQYofeK5cymVJNMiYQIbj2xUKZJanOpypwrH1WVs7maXomvC7nYQafjvzBBVjnk_j6nx2w9HJkMozlpqmryI3q9U76gwXIdqtQD9FBIYL8Q1J9_3ek8KBBq3Rt8UxIuH62HosgrmkYGgVfaO3eK-8rTffQzlqHzp-jJwB_xSd_FZ2jH18_Ro9mwQv4C_QbccZAMtnhd4mXVNFCsYMqv8HWQ3n2fn7S4qvGml8Z63K2xddvO42bddnX4loP9DbS3m3iuqD4w4gHM1dLf3K4-4mbZLe0KCGp4Sumvob5gWxc4NiCa2pfo6vzs8nRKhl0WiONZ2hHHXJHoTNvg5KaSzDIgHU4Jz7KMOpj0VupcyIKnlmpHrbVUJaWXmS0lK6zmr9Buva79PsJh33KprAPaIQTQdpsJJ7kWRU7DLpXpAfo0Dq5pejMNM6rMfpqIhQlYmIQZwOIAqREA81dMGEj3_77xaITLDFOyNVQLHqxtOHTjdQ_hXSfCaiJLND_83ze-Q4-nl7MLc_Fl_u0N2gtneqHaEdrtNlt_DMyly9_GyPwDXbzpTQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+roles+of+hippocampal+microRNAs+in+response+to+acute+postnatal+exposure+to+di%282-ethylhexyl%29+phthalate+in+female+and+male+rats&rft.jtitle=Neurotoxicology+%28Park+Forest+South%29&rft.au=Luu%2C+Bryan+E&rft.au=Green%2C+Stuart+R&rft.au=Childers%2C+Christine+L&rft.au=Holahan%2C+Matthew+R&rft.date=2017-03-01&rft.pub=Elsevier+BV&rft.issn=0161-813X&rft.eissn=1872-9711&rft.volume=59&rft.spage=98&rft_id=info:doi/10.1016%2Fj.neuro.2017.02.004&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0161-813X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0161-813X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0161-813X&client=summon