Sex-Specific Differences in Echocardiographic Parameters of Risk Stratification in Pulmonary Arterial Hypertension
In healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study was to investigate sex differences in echocardiographic European Society of Cardiology (ESC)/European Respiratory Society (ERS) risk stratification pa...
Saved in:
| Published in | Journal of the American Society of Echocardiography Vol. 38; no. 3; pp. 273 - 285 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.03.2025
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | In healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study was to investigate sex differences in echocardiographic European Society of Cardiology (ESC)/European Respiratory Society (ERS) risk stratification parameters and their impact on survival estimation in patients with pulmonary arterial hypertension (PAH).
In this retrospective, cross-sectional study with a mean follow-up time of 3.2 ± 2.65 years (median, 2.78 years), clinical parameters including right atrial (RA) area, right ventricular area, and tricuspid annular plane systolic excursion (TAPSE) divided by systolic pulmonary artery pressure (sPAP) were assessed. Thresholds of ESC/ERS risk stratification were compared using multivariable Cox regression analysis.
Of 748 patients with PAH (mean age, 65 ± 15 years; 63% women), men had significantly larger right heart size than women (RA area 21.76 ± 7.64 vs 17.65 ± 6.82 cm2, P < .001; right ventricular area 24.02 ± 7.15 cm2 vs 18.41 ± 5.75 cm2, P < .001). This difference was consistent throughout all World Health Organization functional classes and cardiac index risk groups, except for the RA area in the cardiac index high-risk group and World Health Organization functional class IV. On multivariable analysis, indexed values showed more pronounced differences for age-adjusted survival analysis compared with ESC/ERS risk stratification thresholds. TAPSE/sPAP showed no significant sex differences, which makes this parameter a robust prognostic predictor.
This is the first study focusing on sex differences in right heart size obtained by echocardiography in patients with PAH. For risk stratification indexing RA area to body surface area could be more reflective of body composition. In contrast, TAPSE/sPAP values were not sex dependent and were a robust prognostic factor in patients with PAH.
XXX. [Display omitted]
•Right heart size differs between sexes in pulmonary arterial hypertension.•Sex is associated with right heart size independent of body size and clinical status.•TAPSE/sPAP is a robust predictor of survival independent of sex.•Sex-specific RA area thresholds adjusted by BSA are superior to general thresholds.•ESC/ERS risk stratification for patients with PAH might need sex-specific adaptation. |
|---|---|
| AbstractList | In healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study was to investigate sex differences in echocardiographic European Society of Cardiology (ESC)/European Respiratory Society (ERS) risk stratification parameters and their impact on survival estimation in patients with pulmonary arterial hypertension (PAH).
In this retrospective, cross-sectional study with a mean follow-up time of 3.2 ± 2.65 years (median, 2.78 years), clinical parameters including right atrial (RA) area, right ventricular area, and tricuspid annular plane systolic excursion (TAPSE) divided by systolic pulmonary artery pressure (sPAP) were assessed. Thresholds of ESC/ERS risk stratification were compared using multivariable Cox regression analysis.
Of 748 patients with PAH (mean age, 65 ± 15 years; 63% women), men had significantly larger right heart size than women (RA area 21.76 ± 7.64 vs 17.65 ± 6.82 cm2, P < .001; right ventricular area 24.02 ± 7.15 cm2 vs 18.41 ± 5.75 cm2, P < .001). This difference was consistent throughout all World Health Organization functional classes and cardiac index risk groups, except for the RA area in the cardiac index high-risk group and World Health Organization functional class IV. On multivariable analysis, indexed values showed more pronounced differences for age-adjusted survival analysis compared with ESC/ERS risk stratification thresholds. TAPSE/sPAP showed no significant sex differences, which makes this parameter a robust prognostic predictor.
This is the first study focusing on sex differences in right heart size obtained by echocardiography in patients with PAH. For risk stratification indexing RA area to body surface area could be more reflective of body composition. In contrast, TAPSE/sPAP values were not sex dependent and were a robust prognostic factor in patients with PAH.
XXX. [Display omitted]
•Right heart size differs between sexes in pulmonary arterial hypertension.•Sex is associated with right heart size independent of body size and clinical status.•TAPSE/sPAP is a robust predictor of survival independent of sex.•Sex-specific RA area thresholds adjusted by BSA are superior to general thresholds.•ESC/ERS risk stratification for patients with PAH might need sex-specific adaptation. In healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study was to investigate sex differences in echocardiographic European Society of Cardiology (ESC)/European Respiratory Society (ERS) risk stratification parameters and their impact on survival estimation in patients with pulmonary arterial hypertension (PAH). In this retrospective, cross-sectional study with a mean follow-up time of 3.2 ± 2.65 years (median, 2.78 years), clinical parameters including right atrial (RA) area, right ventricular area, and tricuspid annular plane systolic excursion (TAPSE) divided by systolic pulmonary artery pressure (sPAP) were assessed. Thresholds of ESC/ERS risk stratification were compared using multivariable Cox regression analysis. Of 748 patients with PAH (mean age, 65 ± 15 years; 63% women), men had significantly larger right heart size than women (RA area 21.76 ± 7.64 vs 17.65 ± 6.82 cm , P < .001; right ventricular area 24.02 ± 7.15 cm vs 18.41 ± 5.75 cm , P < .001). This difference was consistent throughout all World Health Organization functional classes and cardiac index risk groups, except for the RA area in the cardiac index high-risk group and World Health Organization functional class IV. On multivariable analysis, indexed values showed more pronounced differences for age-adjusted survival analysis compared with ESC/ERS risk stratification thresholds. TAPSE/sPAP showed no significant sex differences, which makes this parameter a robust prognostic predictor. This is the first study focusing on sex differences in right heart size obtained by echocardiography in patients with PAH. For risk stratification indexing RA area to body surface area could be more reflective of body composition. In contrast, TAPSE/sPAP values were not sex dependent and were a robust prognostic factor in patients with PAH. BackgroundIn healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study was to investigate sex differences in echocardiographic European Society of Cardiology (ESC)/European Respiratory Society (ERS) risk stratification parameters and their impact on survival estimation in patients with pulmonary arterial hypertension (PAH). MethodsIn this retrospective, cross-sectional study with a mean follow-up time of 3.2 ± 2.65 years (median, 2.78 years), clinical parameters including right atrial (RA) area, right ventricular area, and tricuspid annular plane systolic excursion (TAPSE) divided by systolic pulmonary artery pressure (sPAP) were assessed. Thresholds of ESC/ERS risk stratification were compared using multivariable Cox regression analysis. ResultsOf 748 patients with PAH (mean age, 65 ± 15 years; 63% women), men had significantly larger right heart size than women (RA area 21.76 ± 7.64 vs 17.65 ± 6.82 cm 2, P < .001; right ventricular area 24.02 ± 7.15 cm 2 vs 18.41 ± 5.75 cm 2, P < .001). This difference was consistent throughout all World Health Organization functional classes and cardiac index risk groups, except for the RA area in the cardiac index high-risk group and World Health Organization functional class IV. On multivariable analysis, indexed values showed more pronounced differences for age-adjusted survival analysis compared with ESC/ERS risk stratification thresholds. TAPSE/sPAP showed no significant sex differences, which makes this parameter a robust prognostic predictor. ConclusionsThis is the first study focusing on sex differences in right heart size obtained by echocardiography in patients with PAH. For risk stratification indexing RA area to body surface area could be more reflective of body composition. In contrast, TAPSE/sPAP values were not sex dependent and were a robust prognostic factor in patients with PAH. In healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study was to investigate sex differences in echocardiographic European Society of Cardiology (ESC)/European Respiratory Society (ERS) risk stratification parameters and their impact on survival estimation in patients with pulmonary arterial hypertension (PAH).BACKGROUNDIn healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study was to investigate sex differences in echocardiographic European Society of Cardiology (ESC)/European Respiratory Society (ERS) risk stratification parameters and their impact on survival estimation in patients with pulmonary arterial hypertension (PAH).In this retrospective, cross-sectional study with a mean follow-up time of 3.2 ± 2.65 years (median, 2.78 years), clinical parameters including right atrial (RA) area, right ventricular area, and tricuspid annular plane systolic excursion (TAPSE) divided by systolic pulmonary artery pressure (sPAP) were assessed. Thresholds of ESC/ERS risk stratification were compared using multivariable Cox regression analysis.METHODSIn this retrospective, cross-sectional study with a mean follow-up time of 3.2 ± 2.65 years (median, 2.78 years), clinical parameters including right atrial (RA) area, right ventricular area, and tricuspid annular plane systolic excursion (TAPSE) divided by systolic pulmonary artery pressure (sPAP) were assessed. Thresholds of ESC/ERS risk stratification were compared using multivariable Cox regression analysis.Of 748 patients with PAH (mean age, 65 ± 15 years; 63% women), men had significantly larger right heart size than women (RA area 21.76 ± 7.64 vs 17.65 ± 6.82 cm2, P < .001; right ventricular area 24.02 ± 7.15 cm2 vs 18.41 ± 5.75 cm2, P < .001). This difference was consistent throughout all World Health Organization functional classes and cardiac index risk groups, except for the RA area in the cardiac index high-risk group and World Health Organization functional class IV. On multivariable analysis, indexed values showed more pronounced differences for age-adjusted survival analysis compared with ESC/ERS risk stratification thresholds. TAPSE/sPAP showed no significant sex differences, which makes this parameter a robust prognostic predictor.RESULTSOf 748 patients with PAH (mean age, 65 ± 15 years; 63% women), men had significantly larger right heart size than women (RA area 21.76 ± 7.64 vs 17.65 ± 6.82 cm2, P < .001; right ventricular area 24.02 ± 7.15 cm2 vs 18.41 ± 5.75 cm2, P < .001). This difference was consistent throughout all World Health Organization functional classes and cardiac index risk groups, except for the RA area in the cardiac index high-risk group and World Health Organization functional class IV. On multivariable analysis, indexed values showed more pronounced differences for age-adjusted survival analysis compared with ESC/ERS risk stratification thresholds. TAPSE/sPAP showed no significant sex differences, which makes this parameter a robust prognostic predictor.This is the first study focusing on sex differences in right heart size obtained by echocardiography in patients with PAH. For risk stratification indexing RA area to body surface area could be more reflective of body composition. In contrast, TAPSE/sPAP values were not sex dependent and were a robust prognostic factor in patients with PAH.CONCLUSIONSThis is the first study focusing on sex differences in right heart size obtained by echocardiography in patients with PAH. For risk stratification indexing RA area to body surface area could be more reflective of body composition. In contrast, TAPSE/sPAP values were not sex dependent and were a robust prognostic factor in patients with PAH. |
| Author | Grünig, Ekkehard Eichstaedt, Christina A. Xanthouli, Panagiota Marra, Alberto M. Braun, Moritz Schiffer, Veronika Harutyunova, Satenik Resag, Carolin Egenlauf, Benjamin Benjamin, Nicola Cittadini, Antonio Kiely, David G. Bossone, Eduardo |
| Author_xml | – sequence: 1 givenname: Nicola orcidid: 0000-0003-4730-969X surname: Benjamin fullname: Benjamin, Nicola email: nicola.benjamin@med.uni-heidelberg.de organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany – sequence: 2 givenname: Veronika surname: Schiffer fullname: Schiffer, Veronika organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany – sequence: 3 givenname: Carolin surname: Resag fullname: Resag, Carolin organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany – sequence: 4 givenname: Panagiota surname: Xanthouli fullname: Xanthouli, Panagiota organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany – sequence: 5 givenname: Moritz surname: Braun fullname: Braun, Moritz organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany – sequence: 6 givenname: Satenik surname: Harutyunova fullname: Harutyunova, Satenik organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany – sequence: 7 givenname: Christina A. surname: Eichstaedt fullname: Eichstaedt, Christina A. organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany – sequence: 8 givenname: Benjamin surname: Egenlauf fullname: Egenlauf, Benjamin organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany – sequence: 9 givenname: Alberto M. surname: Marra fullname: Marra, Alberto M. organization: Department of Translational Medical Sciences, University Federico II of Naples, Naples, Italy – sequence: 10 givenname: Eduardo surname: Bossone fullname: Bossone, Eduardo organization: Department of Public Health, Department of Translational Medical Sciences, Interdepartmental Genesis Center, Federico II University, Naples, Italy – sequence: 11 givenname: Antonio surname: Cittadini fullname: Cittadini, Antonio organization: Department of Translational Medical Sciences, University Federico II of Naples, Naples, Italy – sequence: 12 givenname: David G. surname: Kiely fullname: Kiely, David G. organization: Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, NIHR Biomedical Research Centre, Sheffield, United Kingdom – sequence: 13 givenname: Ekkehard surname: Grünig fullname: Grünig, Ekkehard organization: Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39706311$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1u1DAUhS1URKeFF2CBsmSTcO38OEYIqSotRapExcDacpwb6mlip3aCOm-PrSkskICN7cV3ju8954QcWWeRkJcUCgq0ebMrUN-6ggGrCkoLoPUTsqEgeN5wUR-RDbSiynlJ-TE5CWEHAHUL8Iwcl4JDU1K6IX6LD_l2Rm0Go7MPZhjQo9UYMmOzi2ivle-N--7VfBuBG-XVhAv6kLkh-2LCXbZdvFqSOp7OJtnNOk7OKr_PznxEjRqzq_2M8W1DRJ6Tp4MaA754vE_Jt8uLr-dX-fXnj5_Oz65zXbZ8yTtKSy5YX7a9qpuOMQagdIdNzZlqRN92AIJWumpFV7F6aIe2QcGrjmHHGRflKXl98J29u18xLHIyQeM4KotuDbKkFRe8rKGN6KtHdO0m7OXszRTnl79yigA7ANq7EDwOvxEKMpUhdzKVIVMZklIZy4iidwcRxi1_GPQyaJPC7Y1HvcjemX_L3_8h16OxMefxDvcYdm71NuYnqQxMgtymtlPZrII4dJMCePt3g__9_hOoDbr- |
| Cites_doi | 10.1007/s11906-016-0689-7 10.1016/j.cardfail.2018.11.013 10.1161/CIRCIMAGING.115.003810 10.1161/CIRCULATIONAHA.108.800938 10.1016/S0735-1097(02)01744-8 10.1111/echo.13531 10.1016/j.ijcard.2018.12.040 10.1016/j.ijcard.2018.01.053 10.1016/j.echo.2012.08.013 10.1111/j.1540-8175.2010.01290.x 10.1016/j.echo.2010.05.010 10.3389/fphys.2022.831179 10.1016/j.jcmg.2022.12.020 10.1161/HCI.0000000000000027 10.1111/echo.12909 10.1002/j.2040-4603.2020.tb00109.x 10.1183/13993003.00879-2022 10.1136/thx.39.11.818 10.1164/rccm.202006-2147ED 10.1016/j.ijcard.2012.10.026 10.1161/CIRCIMAGING.112.978031 10.1164/rccm.201007-1027OC 10.1016/j.phrs.2016.10.018 10.1159/000371472 10.1016/j.amjcard.2023.03.016 10.1161/CIRCULATIONAHA.110.985515 10.1016/j.healun.2021.11.004 10.1161/01.CIR.70.4.657 10.1038/s41598-021-01968-y 10.1067/mje.2002.123962 |
| ContentType | Journal Article |
| Copyright | 2024 American Society of Echocardiography American Society of Echocardiography Copyright © 2024 American Society of Echocardiography. All rights reserved. |
| Copyright_xml | – notice: 2024 American Society of Echocardiography – notice: American Society of Echocardiography – notice: Copyright © 2024 American Society of Echocardiography. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.echo.2024.11.015 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1097-6795 |
| EndPage | 285 |
| ExternalDocumentID | 39706311 10_1016_j_echo_2024_11_015 S0894731724006369 1_s2_0_S0894731724006369 |
| Genre | Journal Article |
| GroupedDBID | --- --K -RU .1- .FO .GJ .XZ 0R~ 1B1 1P~ 4.4 457 53G 5GY 5RE 5VS 6PF AAEDT AAEDW AALRI AAQFI AAQQT AAQXK AAWTL AAXUO AAYWO ABDQB ABFRF ABJNI ABLJU ABMAC ABOCM ABWVN ACGFO ACGFS ACRPL ACVFH ADBBV ADCNI ADMUD ADNMO ADVLN AEFWE AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AGCQF AGQPQ AIGII AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN BELOY C45 C5W CAG COF CS3 DU5 EBS EFJIC EFKBS EJD EX3 F5P FDB FEDTE FGOYB GBLVA HVGLF HZ~ IHE K-O KOM M41 MO0 N9A NQ- O9- OA. OL~ OVD P2P R2- ROL RPZ SEL SES SJN SSZ TEORI UNMZH UV1 WOW XH2 Z5R AFCTW RIG 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c387t-b113792d38da56b22200acbe6572a69d8b00914c489b425f8f86e974b2eb72793 |
| ISSN | 0894-7317 1097-6795 |
| IngestDate | Thu Jul 10 18:38:38 EDT 2025 Mon Jul 21 05:47:27 EDT 2025 Wed Aug 20 07:47:25 EDT 2025 Sat Jul 05 17:10:33 EDT 2025 Fri Jun 27 03:51:14 EDT 2025 Tue Aug 26 16:32:28 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | TAPSE/sPAP Prognosis RV TTE ERS TAPSE RHC Sex difference Survival PVR RA BSA Right ventricular area ESC PAH PH sPAP Right atrial area BMI WHO Right atrial Right heart catheterization Body mass index European Respiratory Society Pulmonary arterial hypertension Body surface area Pulmonary vascular resistance Systolic pulmonary artery pressure World Health Organization Transthoracic echocardiography Pulmonary hypertension European Society of Cardiology Tricuspid annular plane systolic excursion Right ventricular |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2024 American Society of Echocardiography. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c387t-b113792d38da56b22200acbe6572a69d8b00914c489b425f8f86e974b2eb72793 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-4730-969X |
| OpenAccessLink | https://www.clinicalkey.com/#!/content/1-s2.0-S0894731724006369 |
| PMID | 39706311 |
| PQID | 3147973508 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | proquest_miscellaneous_3147973508 pubmed_primary_39706311 crossref_primary_10_1016_j_echo_2024_11_015 elsevier_sciencedirect_doi_10_1016_j_echo_2024_11_015 elsevier_clinicalkeyesjournals_1_s2_0_S0894731724006369 elsevier_clinicalkey_doi_10_1016_j_echo_2024_11_015 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-03-01 |
| PublicationDateYYYYMMDD | 2025-03-01 |
| PublicationDate_xml | – month: 03 year: 2025 text: 2025-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of the American Society of Echocardiography |
| PublicationTitleAlternate | J Am Soc Echocardiogr |
| PublicationYear | 2025 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Grünig, Biskupek, D'Andrea (bib9) 2015; 89 Tello, Naeije, Ghofrani (bib5) 2019; 278 Douglas, Carabello, Lang (bib14) 2019; 12 Hernandez-Suarez, Lopez Menendez, Lopez-Candales (bib22) 2017; 34 Batal, Dardari, Costabile (bib6) 2015; 32 Yock, Popp (bib16) 1984; 70 Ogunyankin, Liu, Lloyd-Jones (bib19) 2011; 28 Marra, Benjamin, Eichstaedt (bib25) 2016; 114 Keller, Sinning, Schulz (bib20) 2021; 11 Hester, Ventetuolo, Lahm (bib26) 2019; 10 Tello, Axmann, Ghofrani (bib4) 2018; 266 van Wezenbeek, Groeneveldt, Llucia-Valldeperas (bib29) 2022; 41 D'Oronzio, Senn, Biaggi (bib18) 2012; 25 Foderaro, Ventetuolo (bib27) 2016; 18 Foppa, Arora, Gona (bib24) 2016; 9 Ventetuolo, Ouyang, Bluemke (bib31) 2011; 183 Grünig, Henn, D'Andrea (bib8) 2013; 6 Guyatt, Pugsley, Sullivan (bib17) 1984; 39 Raymond, Hinderliter, Willis (bib2) 2002; 39 Bustamante-Labarta, Perrone, De La Fuente (bib3) 2002; 15 Mukherjee, Ogunmoroti, Jani (bib12) 2023; 196 Hoeper, Huscher, Ghofrani (bib7) 2013; 168 Wolsk, Bakkestrom, Kristensen (bib11) 2019; 25 Kawut, Lima, Barr (bib10) 2011; 123 Humbert, Kovacs, Hoeper (bib1) 2023; 61 St Pierre, Peirlinck, Kuhl (bib21) 2022; 13 Eriksen-Volnes, Grue, Hellum Olaisen (bib23) 2023; 16 Keen, Prisco, Prins (bib30) 2020; 11 Thenappan, Weir (bib28) 2020; 202 Grunig, Weissmann, Ehlken (bib13) 2009; 119 Rudski, Lai, Afilalo (bib15) 2010; 23 Foderaro (10.1016/j.echo.2024.11.015_bib27) 2016; 18 Hernandez-Suarez (10.1016/j.echo.2024.11.015_bib22) 2017; 34 Grunig (10.1016/j.echo.2024.11.015_bib13) 2009; 119 Mukherjee (10.1016/j.echo.2024.11.015_bib12) 2023; 196 Marra (10.1016/j.echo.2024.11.015_bib25) 2016; 114 Tello (10.1016/j.echo.2024.11.015_bib4) 2018; 266 Foppa (10.1016/j.echo.2024.11.015_bib24) 2016; 9 Keller (10.1016/j.echo.2024.11.015_bib20) 2021; 11 Guyatt (10.1016/j.echo.2024.11.015_bib17) 1984; 39 Raymond (10.1016/j.echo.2024.11.015_bib2) 2002; 39 Douglas (10.1016/j.echo.2024.11.015_bib14) 2019; 12 Kawut (10.1016/j.echo.2024.11.015_bib10) 2011; 123 Thenappan (10.1016/j.echo.2024.11.015_bib28) 2020; 202 Humbert (10.1016/j.echo.2024.11.015_bib1) 2023; 61 Rudski (10.1016/j.echo.2024.11.015_bib15) 2010; 23 van Wezenbeek (10.1016/j.echo.2024.11.015_bib29) 2022; 41 Keen (10.1016/j.echo.2024.11.015_bib30) 2020; 11 Hoeper (10.1016/j.echo.2024.11.015_bib7) 2013; 168 Ventetuolo (10.1016/j.echo.2024.11.015_bib31) 2011; 183 Tello (10.1016/j.echo.2024.11.015_bib5) 2019; 278 Grünig (10.1016/j.echo.2024.11.015_bib9) 2015; 89 D'Oronzio (10.1016/j.echo.2024.11.015_bib18) 2012; 25 Bustamante-Labarta (10.1016/j.echo.2024.11.015_bib3) 2002; 15 St Pierre (10.1016/j.echo.2024.11.015_bib21) 2022; 13 Hester (10.1016/j.echo.2024.11.015_bib26) 2019; 10 Wolsk (10.1016/j.echo.2024.11.015_bib11) 2019; 25 Ogunyankin (10.1016/j.echo.2024.11.015_bib19) 2011; 28 Batal (10.1016/j.echo.2024.11.015_bib6) 2015; 32 Grünig (10.1016/j.echo.2024.11.015_bib8) 2013; 6 Yock (10.1016/j.echo.2024.11.015_bib16) 1984; 70 Eriksen-Volnes (10.1016/j.echo.2024.11.015_bib23) 2023; 16 |
| References_xml | – volume: 168 start-page: 871 year: 2013 end-page: 880 ident: bib7 article-title: Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry publication-title: Int J Cardiol – volume: 11 year: 2020 ident: bib30 article-title: Sex differences in right ventricular dysfunction: insights from the bench to bedside publication-title: Front Physiol – volume: 12 year: 2019 ident: bib14 article-title: 2019 ACC/AHA/ASE key data elements and definitions for transthoracic echocardiography: a report of the American College of Cardiology/American Heart Association task force on clinical data standards (Writing committee to develop cardiovascular endpoints data standards) and the American Society of Echocardiography publication-title: Circ Cardiovasc Imaging – volume: 39 start-page: 818 year: 1984 end-page: 822 ident: bib17 article-title: Effect of encouragement on walking test performance publication-title: Thorax – volume: 11 year: 2021 ident: bib20 article-title: Right atrium size in the general population publication-title: Sci Rep – volume: 32 start-page: 1471 year: 2015 end-page: 1476 ident: bib6 article-title: Prognostic value of pericardial effusion on serial Echocardiograms in pulmonary arterial hypertension publication-title: Echocardiography – volume: 6 start-page: 117 year: 2013 end-page: 124 ident: bib8 article-title: Reference values for and determinants of right atrial area in healthy adults by 2-dimensional echocardiography publication-title: Circ Cardiovasc Imaging – volume: 183 start-page: 659 year: 2011 end-page: 667 ident: bib31 article-title: Sex hormones are associated with right ventricular structure and function: the MESA-right ventricle study publication-title: Am J Respir Crit Care Med – volume: 41 start-page: 445 year: 2022 end-page: 457 ident: bib29 article-title: Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort publication-title: J Heart Lung Transplant – volume: 16 start-page: 1501 year: 2023 end-page: 1515 ident: bib23 article-title: Normalized echocardiographic values from guideline-directed dedicated views for cardiac dimensions and left ventricular function publication-title: JACC Cardiovasc Imaging – volume: 39 start-page: 1214 year: 2002 end-page: 1219 ident: bib2 article-title: Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension publication-title: J Am Coll Cardiol – volume: 18 start-page: 84 year: 2016 ident: bib27 article-title: Pulmonary arterial hypertension and the sex hormone paradox publication-title: Curr Hypertens Rep – volume: 202 start-page: 928 year: 2020 end-page: 929 ident: bib28 article-title: Pulmonary arterial hypertension and sex in the right ventricle: it is an interesting picture! publication-title: Am J Respir Crit Care Med – volume: 266 start-page: 229 year: 2018 end-page: 235 ident: bib4 article-title: Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension publication-title: Int J Cardiol – volume: 15 start-page: 1160 year: 2002 end-page: 1164 ident: bib3 article-title: Right atrial size and tricuspid regurgitation severity predict mortality or transplantation in primary pulmonary hypertension publication-title: J Am Soc Echocardiogr – volume: 119 start-page: 1747 year: 2009 end-page: 1757 ident: bib13 article-title: Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia publication-title: Circulation – volume: 25 start-page: 1251 year: 2012 end-page: 1258 ident: bib18 article-title: Right heart assessment by echocardiography: gender and body size matters publication-title: J Am Soc Echocardiogr – volume: 10 start-page: 125 year: 2019 end-page: 170 ident: bib26 article-title: Sex, gender, and sex hormones in pulmonary hypertension and right ventricular failure publication-title: Compr Physiol – volume: 34 start-page: 810 year: 2017 end-page: 816 ident: bib22 article-title: Maximal systolic excursion of the tricuspid annulus is independent of right atrial size and function in chronic pulmonary hypertension publication-title: Echocardiography – volume: 278 start-page: 240 year: 2019 end-page: 241 ident: bib5 article-title: Reply to "a pediatric perspective on the TAPSE/PASP ratio in pulmonary arterial hypertension" publication-title: Int J Cardiol – volume: 28 start-page: 142 year: 2011 end-page: 149 ident: bib19 article-title: Reference values of right ventricular end-diastolic area defined by ethnicity and gender in a young adult population: the CARDIA study publication-title: Echocardiography – volume: 61 year: 2023 ident: bib1 article-title: 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension publication-title: Eur Respir J – volume: 196 start-page: 41 year: 2023 end-page: 51 ident: bib12 article-title: Characteristics of right ventricular to pulmonary arterial coupling and association with functional status among older aged adults from the multi-ethnic study of atherosclerosis publication-title: Am J Cardiol – volume: 89 start-page: 284 year: 2015 end-page: 293 ident: bib9 article-title: Reference ranges for and determinants of right ventricular area in healthy adults by two-dimensional echocardiography publication-title: Respiration – volume: 114 start-page: 103 year: 2016 end-page: 109 ident: bib25 article-title: Gender-related differences in pulmonary arterial hypertension targeted drugs administration publication-title: Pharmacol Res – volume: 25 start-page: 51 year: 2019 end-page: 59 ident: bib11 article-title: Right ventricular and pulmonary vascular function are influenced by age and volume expansion in healthy humans publication-title: J Card Fail – volume: 13 year: 2022 ident: bib21 article-title: Sex matters: a comprehensive comparison of female and male hearts publication-title: Front Physiol – volume: 70 start-page: 657 year: 1984 end-page: 662 ident: bib16 article-title: Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation publication-title: Circulation – volume: 123 start-page: 2542 year: 2011 end-page: 2551 ident: bib10 article-title: Sex and race differences in right ventricular structure and function: the multi-ethnic study of atherosclerosis-right ventricle study publication-title: Circulation – volume: 23 start-page: 685 year: 2010 end-page: 713 ident: bib15 article-title: Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography publication-title: J Am Soc Echocardiogr – volume: 9 year: 2016 ident: bib24 article-title: Right ventricular volumes and systolic function by cardiac magnetic resonance and the impact of sex, age, and obesity in a longitudinally followed cohort free of pulmonary and cardiovascular disease: the framingham heart study publication-title: Circ Cardiovasc Imaging – volume: 18 start-page: 84 year: 2016 ident: 10.1016/j.echo.2024.11.015_bib27 article-title: Pulmonary arterial hypertension and the sex hormone paradox publication-title: Curr Hypertens Rep doi: 10.1007/s11906-016-0689-7 – volume: 25 start-page: 51 year: 2019 ident: 10.1016/j.echo.2024.11.015_bib11 article-title: Right ventricular and pulmonary vascular function are influenced by age and volume expansion in healthy humans publication-title: J Card Fail doi: 10.1016/j.cardfail.2018.11.013 – volume: 9 year: 2016 ident: 10.1016/j.echo.2024.11.015_bib24 article-title: Right ventricular volumes and systolic function by cardiac magnetic resonance and the impact of sex, age, and obesity in a longitudinally followed cohort free of pulmonary and cardiovascular disease: the framingham heart study publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.115.003810 – volume: 119 start-page: 1747 year: 2009 ident: 10.1016/j.echo.2024.11.015_bib13 article-title: Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.108.800938 – volume: 39 start-page: 1214 year: 2002 ident: 10.1016/j.echo.2024.11.015_bib2 article-title: Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(02)01744-8 – volume: 34 start-page: 810 year: 2017 ident: 10.1016/j.echo.2024.11.015_bib22 article-title: Maximal systolic excursion of the tricuspid annulus is independent of right atrial size and function in chronic pulmonary hypertension publication-title: Echocardiography doi: 10.1111/echo.13531 – volume: 278 start-page: 240 year: 2019 ident: 10.1016/j.echo.2024.11.015_bib5 article-title: Reply to "a pediatric perspective on the TAPSE/PASP ratio in pulmonary arterial hypertension" publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2018.12.040 – volume: 266 start-page: 229 year: 2018 ident: 10.1016/j.echo.2024.11.015_bib4 article-title: Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2018.01.053 – volume: 25 start-page: 1251 year: 2012 ident: 10.1016/j.echo.2024.11.015_bib18 article-title: Right heart assessment by echocardiography: gender and body size matters publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2012.08.013 – volume: 28 start-page: 142 year: 2011 ident: 10.1016/j.echo.2024.11.015_bib19 article-title: Reference values of right ventricular end-diastolic area defined by ethnicity and gender in a young adult population: the CARDIA study publication-title: Echocardiography doi: 10.1111/j.1540-8175.2010.01290.x – volume: 23 start-page: 685 year: 2010 ident: 10.1016/j.echo.2024.11.015_bib15 publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2010.05.010 – volume: 13 year: 2022 ident: 10.1016/j.echo.2024.11.015_bib21 article-title: Sex matters: a comprehensive comparison of female and male hearts publication-title: Front Physiol doi: 10.3389/fphys.2022.831179 – volume: 16 start-page: 1501 year: 2023 ident: 10.1016/j.echo.2024.11.015_bib23 article-title: Normalized echocardiographic values from guideline-directed dedicated views for cardiac dimensions and left ventricular function publication-title: JACC Cardiovasc Imaging doi: 10.1016/j.jcmg.2022.12.020 – volume: 12 year: 2019 ident: 10.1016/j.echo.2024.11.015_bib14 publication-title: Circ Cardiovasc Imaging doi: 10.1161/HCI.0000000000000027 – volume: 32 start-page: 1471 year: 2015 ident: 10.1016/j.echo.2024.11.015_bib6 article-title: Prognostic value of pericardial effusion on serial Echocardiograms in pulmonary arterial hypertension publication-title: Echocardiography doi: 10.1111/echo.12909 – volume: 10 start-page: 125 year: 2019 ident: 10.1016/j.echo.2024.11.015_bib26 article-title: Sex, gender, and sex hormones in pulmonary hypertension and right ventricular failure publication-title: Compr Physiol doi: 10.1002/j.2040-4603.2020.tb00109.x – volume: 61 year: 2023 ident: 10.1016/j.echo.2024.11.015_bib1 article-title: 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension publication-title: Eur Respir J doi: 10.1183/13993003.00879-2022 – volume: 39 start-page: 818 year: 1984 ident: 10.1016/j.echo.2024.11.015_bib17 article-title: Effect of encouragement on walking test performance publication-title: Thorax doi: 10.1136/thx.39.11.818 – volume: 202 start-page: 928 year: 2020 ident: 10.1016/j.echo.2024.11.015_bib28 article-title: Pulmonary arterial hypertension and sex in the right ventricle: it is an interesting picture! publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.202006-2147ED – volume: 168 start-page: 871 year: 2013 ident: 10.1016/j.echo.2024.11.015_bib7 article-title: Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2012.10.026 – volume: 6 start-page: 117 year: 2013 ident: 10.1016/j.echo.2024.11.015_bib8 article-title: Reference values for and determinants of right atrial area in healthy adults by 2-dimensional echocardiography publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.112.978031 – volume: 183 start-page: 659 year: 2011 ident: 10.1016/j.echo.2024.11.015_bib31 article-title: Sex hormones are associated with right ventricular structure and function: the MESA-right ventricle study publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201007-1027OC – volume: 114 start-page: 103 year: 2016 ident: 10.1016/j.echo.2024.11.015_bib25 article-title: Gender-related differences in pulmonary arterial hypertension targeted drugs administration publication-title: Pharmacol Res doi: 10.1016/j.phrs.2016.10.018 – volume: 89 start-page: 284 year: 2015 ident: 10.1016/j.echo.2024.11.015_bib9 article-title: Reference ranges for and determinants of right ventricular area in healthy adults by two-dimensional echocardiography publication-title: Respiration doi: 10.1159/000371472 – volume: 196 start-page: 41 year: 2023 ident: 10.1016/j.echo.2024.11.015_bib12 article-title: Characteristics of right ventricular to pulmonary arterial coupling and association with functional status among older aged adults from the multi-ethnic study of atherosclerosis publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2023.03.016 – volume: 123 start-page: 2542 year: 2011 ident: 10.1016/j.echo.2024.11.015_bib10 article-title: Sex and race differences in right ventricular structure and function: the multi-ethnic study of atherosclerosis-right ventricle study publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.110.985515 – volume: 41 start-page: 445 year: 2022 ident: 10.1016/j.echo.2024.11.015_bib29 article-title: Interplay of sex hormones and long-term right ventricular adaptation in a Dutch PAH-cohort publication-title: J Heart Lung Transplant doi: 10.1016/j.healun.2021.11.004 – volume: 70 start-page: 657 year: 1984 ident: 10.1016/j.echo.2024.11.015_bib16 article-title: Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation publication-title: Circulation doi: 10.1161/01.CIR.70.4.657 – volume: 11 year: 2021 ident: 10.1016/j.echo.2024.11.015_bib20 article-title: Right atrium size in the general population publication-title: Sci Rep doi: 10.1038/s41598-021-01968-y – volume: 11 year: 2020 ident: 10.1016/j.echo.2024.11.015_bib30 article-title: Sex differences in right ventricular dysfunction: insights from the bench to bedside publication-title: Front Physiol – volume: 15 start-page: 1160 year: 2002 ident: 10.1016/j.echo.2024.11.015_bib3 article-title: Right atrial size and tricuspid regurgitation severity predict mortality or transplantation in primary pulmonary hypertension publication-title: J Am Soc Echocardiogr doi: 10.1067/mje.2002.123962 |
| SSID | ssj0005800 |
| Score | 2.4503882 |
| Snippet | In healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study was to... BackgroundIn healthy subjects, sex differences in right heart function have been detected for various echocardiographic parameters. The objective of this study... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 273 |
| SubjectTerms | Aged Cardiovascular Cross-Sectional Studies Echocardiography - methods Female Follow-Up Studies Heart Atria - diagnostic imaging Heart Atria - physiopathology Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Male Middle Aged Prognosis Pulmonary Arterial Hypertension - diagnostic imaging Pulmonary Arterial Hypertension - mortality Pulmonary Arterial Hypertension - physiopathology Retrospective Studies Right atrial area Right ventricular area Risk Assessment - methods Sex difference Sex Factors Survival Survival Rate TAPSE/sPAP Ventricular Function, Right - physiology |
| Title | Sex-Specific Differences in Echocardiographic Parameters of Risk Stratification in Pulmonary Arterial Hypertension |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0894731724006369 https://www.clinicalkey.es/playcontent/1-s2.0-S0894731724006369 https://dx.doi.org/10.1016/j.echo.2024.11.015 https://www.ncbi.nlm.nih.gov/pubmed/39706311 https://www.proquest.com/docview/3147973508 |
| Volume | 38 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zj9MwELbKroR4WXFTLhmJN5QqiXM4jwUtVIhFK7qL-mbZib20sCnqISH-FH-RGdtJ0-0ux75EVSp3nJmv4xnnmzEhL02sdFKGaWAqnQeJBBhzyUyg0zwpDdeVsSSao4_Z6DR5P0knvd6vDmtpvVKD8ueldSXXsSrcA7tilex_WLb9UbgBn8G-cAULw_WfbDzWPwJ7gLyZluC8jK_dsxTXQ_BrpSWb2p7UyICXSMTCbpq2Awlyym1vWhwtG87j8fobTB-pdEMke-J--ghS1YUlunsT7saynfqUuiWCImdxexKb4gldz-S5a19gsdguDuPyi30Oy7_V2Lj3a_vdJ72UZy1LZdrCeiKxA4Iv9D62By_NV7K7nxGnG0KX22RrCm22eKAhL5IgZ67Ms3HcjHcAyrpe2J2O4hf02J0JtLNWuG2L2UCDKgYwk2SA7VxdcemFHtxjlI_ikXGbsay4QfZjyEvAse6_e_3h83DDKuKu6qmZr6_TcpTCi5KuioWuynVszHNymxx4A9OhQ94d0tP1XXLzyNMx7pFFF4C0A0A6rekOAOkGgHRuKAKQbgMQh7UApA0AaReA98np28OTN6PAH-IRlIznq0BFEcuLuGK8kmmmIBwNQ1kqnaV5LLOi4uD3iygpE14oWD8MNzzTkOSqWCuIrQv2gOzV81o_IhQUHhZchyoLVcLAr4QVpP-yyAxE1Vku--RVo07x3fVqEQ2JcSZQ-QKVD0mvAOX3CWs0LpoqZFg3BcDjj6Pyy0bppXcLSxGJZSxCsQOZPknbkT66dVHrXyW-aOAgwPXj-zxZ6_l6KViU5EXOIMXqk4cOJ-1zQ5oBUqPo8TWlPiG3Nn_Op2RvtVjrZxB-r9RzD_nfv13gKQ |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sex-Specific+Differences+in+Echocardiographic+Parameters+of+Risk+Stratification+in+Pulmonary+Arterial+Hypertension&rft.jtitle=Journal+of+the+American+Society+of+Echocardiography&rft.au=Benjamin%2C+Nicola&rft.au=Schiffer%2C+Veronika&rft.au=Resag%2C+Carolin&rft.au=Xanthouli%2C+Panagiota&rft.date=2025-03-01&rft.pub=Elsevier+Inc&rft.issn=0894-7317&rft.volume=38&rft.issue=3&rft.spage=273&rft.epage=285&rft_id=info:doi/10.1016%2Fj.echo.2024.11.015&rft.externalDocID=S0894731724006369 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F08947317%2FS0894731725X00031%2Fcov150h.gif |