Effect of bacterial chemotactic peptides on intestinal inflammation in animal models of acute and chronic relapsed colitis

• Published in: Digestive diseases and sciences Vol. 50; no. 8; pp. 1444 - 1453
• Main Authors: HERNANDEZ, Gerardo A, VALENTIN, Melanie R, APPLEYARD, Caroline B
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.08.2005; Springer Nature B.V
• Subjects: Acute Disease; Animals; Bacteria; Bacterial Proteins - pharmacology; Biological and medical sciences; Chronic Disease; Colitis - etiology; Colitis - metabolism; Colitis - physiopathology; Disease Models, Animal; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Gastric Mucosa - drug effects; Gastric Mucosa - metabolism; Gastric Mucosa - physiopathology; Gastroenterology. Liver. Pancreas. Abdomen; Male; Medical sciences; N-Formylmethionine Leucyl-Phenylalanine - pharmacology; Other diseases. Semiology; Rats; Rats, Sprague-Dawley; Recurrence; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Animal model; Rat; Acute; Rodentia; Metabolic diseases; Inflammation; Chemotactic peptide; inflammatory bowel disease; Inflammatory disease; Crohn disease; Vertebrata; Chronic; Mammalia; Animal; bacterial peptides; Gastroenterology; Digestive diseases; Intestinal disease; trinitrobenzenesulfonic acid; Colitis; Ulcerative colitis
• DOI: 10.1007/s10620-005-2859-3
• ISSN: 0163-2116

It is known that bacterial chemotactic peptides such as formyl-methionyl-leucyl-phenylalanine (fMLP) exacerbate colitis during the acute phase, but the precise role of fMLP during chronic "relapse" is unknown. In this study we examined the effect of bacterial peptides in animal models of acute and chronic "relapsed" colitis. Different parameters were evaluated, such as tissue damage, myeloperoxidase activity, and mucosal function. In acute trinitrobenezene sulfonic acid colitis, fMLP had significant adverse effects on mucosal function and worsened several parameters. In contrast, in chronic "relapsed" colitis the ability of fMLP to exacerbate the inflammation was dependent on whether it was confined to the lumen of the colon. Bacterial peptides such as fMLP appear to play a different role in the acute phase of inflammation compared with the chronic phase, depending on the integrity of the mucosal barrier.