Ectopic Agouti protein overexpression increases stimulated corticosterone production without effect on adenylate cyclase activity in mouse adrenal cells

• Published in: European journal of endocrinology Vol. 151; no. 5; pp. 613 - 618
• Main Authors: SHEVCHENKO, Antonyna Y, BAZHAN, Nadezhda M, MAKAROVA, Elena N, YAKOVLEVA, Tatyana V, KARKAEVA, Nelli R
• Format: Journal Article
• Language: Russian; English
• Published: Colchester Portland Press 01.11.2004
• Subjects: Adenylyl Cyclases - metabolism; Adrenal Glands - cytology; Adrenal Glands - drug effects; Adrenal Glands - enzymology; Adrenal Glands - metabolism; Adrenocorticotropic Hormone - pharmacology; Agouti Signaling Protein; Agouti-Related Protein; Animals; Bucladesine - pharmacology; Colforsin - pharmacology; Corticosterone - biosynthesis; Cyclic AMP - metabolism; Genes, Dominant; Genotype; Intercellular Signaling Peptides and Proteins - metabolism; Male; Mice; Mice, Inbred C57BL - genetics; Mutation; Progesterone - pharmacology; Tissue Distribution

The antagonism of Agouti protein (AP) and Agouti-related protein on melanocortin receptors suggests an inhibitory role in the regulation of steroidogenesis. However, we have previously demonstrated that ectopic AP overexpression increased restraint-induced corticosterone release and adrenal reactivi...