Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder
Dopamine and cyclic adenosine 3′:5′-monophosphate (AMP)-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32), plays an important role in modulating the functions of various neurotransmitter systems. To explore the alterations in DARPP-32 in subjects with schizophrenia and bipolar diso...
Saved in:
| Published in | Progress in neuro-psychopharmacology & biological psychiatry Vol. 31; no. 6; pp. 1177 - 1181 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Inc
15.08.2007
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0278-5846 1878-4216 |
| DOI | 10.1016/j.pnpbp.2007.04.013 |
Cover
Loading…
| Abstract | Dopamine and cyclic adenosine 3′:5′-monophosphate (AMP)-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32), plays an important role in modulating the functions of various neurotransmitter systems. To explore the alterations in DARPP-32 in subjects with schizophrenia and bipolar disorder, we employed immunohistochemical and Western blotting techniques and examined the distribution and expression of DARPP-32 in the postmortem dorsolateral prefrontal cortex (DLPFC) from 12 subjects with schizophrenia, 10 subjects with bipolar disorder, and 11 control subjects. Immunohistochemical study demonstrated that DARPP-32 immunolabeling in the neuronal soma from subjects with schizophrenia and bipolar disorder was lower than in that from the controls. The results of the immunoblot analysis were consistent with those of the immunohistochemistry, and the amount of DARPP-32 in subjects with schizophrenia and bipolar disorder was found to be lower than that in the control subjects. The present study suggests that DARPP-32 decreases in the DLPFC of patients with schizophrenia and bipolar disorder, and further suggests that this decrease is associated with dysfunction of dopaminoceptive neurons in the DLPFC of patients affected by these two mental disorders. |
|---|---|
| AbstractList | Dopamine and cyclic adenosine 3′:5′-monophosphate (AMP)-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32), plays an important role in modulating the functions of various neurotransmitter systems. To explore the alterations in DARPP-32 in subjects with schizophrenia and bipolar disorder, we employed immunohistochemical and Western blotting techniques and examined the distribution and expression of DARPP-32 in the postmortem dorsolateral prefrontal cortex (DLPFC) from 12 subjects with schizophrenia, 10 subjects with bipolar disorder, and 11 control subjects. Immunohistochemical study demonstrated that DARPP-32 immunolabeling in the neuronal soma from subjects with schizophrenia and bipolar disorder was lower than in that from the controls. The results of the immunoblot analysis were consistent with those of the immunohistochemistry, and the amount of DARPP-32 in subjects with schizophrenia and bipolar disorder was found to be lower than that in the control subjects. The present study suggests that DARPP-32 decreases in the DLPFC of patients with schizophrenia and bipolar disorder, and further suggests that this decrease is associated with dysfunction of dopaminoceptive neurons in the DLPFC of patients affected by these two mental disorders. Dopamine and cyclic adenosine 3':5'-monophosphate (AMP)-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32), plays an important role in modulating the functions of various neurotransmitter systems. To explore the alterations in DARPP-32 in subjects with schizophrenia and bipolar disorder, we employed immunohistochemical and Western blotting techniques and examined the distribution and expression of DARPP-32 in the postmortem dorsolateral prefrontal cortex (DLPFC) from 12 subjects with schizophrenia, 10 subjects with bipolar disorder, and 11 control subjects. Immunohistochemical study demonstrated that DARPP-32 immunolabeling in the neuronal soma from subjects with schizophrenia and bipolar disorder was lower than in that from the controls. The results of the immunoblot analysis were consistent with those of the immunohistochemistry, and the amount of DARPP-32 in subjects with schizophrenia and bipolar disorder was found to be lower than that in the control subjects. The present study suggests that DARPP-32 decreases in the DLPFC of patients with schizophrenia and bipolar disorder, and further suggests that this decrease is associated with dysfunction of dopaminoceptive neurons in the DLPFC of patients affected by these two mental disorders.Dopamine and cyclic adenosine 3':5'-monophosphate (AMP)-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32), plays an important role in modulating the functions of various neurotransmitter systems. To explore the alterations in DARPP-32 in subjects with schizophrenia and bipolar disorder, we employed immunohistochemical and Western blotting techniques and examined the distribution and expression of DARPP-32 in the postmortem dorsolateral prefrontal cortex (DLPFC) from 12 subjects with schizophrenia, 10 subjects with bipolar disorder, and 11 control subjects. Immunohistochemical study demonstrated that DARPP-32 immunolabeling in the neuronal soma from subjects with schizophrenia and bipolar disorder was lower than in that from the controls. The results of the immunoblot analysis were consistent with those of the immunohistochemistry, and the amount of DARPP-32 in subjects with schizophrenia and bipolar disorder was found to be lower than that in the control subjects. The present study suggests that DARPP-32 decreases in the DLPFC of patients with schizophrenia and bipolar disorder, and further suggests that this decrease is associated with dysfunction of dopaminoceptive neurons in the DLPFC of patients affected by these two mental disorders. |
| Author | Ishikawa, Masanori Asada, Takashi Mizukami, Katsuyoshi Iwakiri, Masahiko |
| Author_xml | – sequence: 1 givenname: Masanori surname: Ishikawa fullname: Ishikawa, Masanori – sequence: 2 givenname: Katsuyoshi surname: Mizukami fullname: Mizukami, Katsuyoshi email: mizukami@md.tsukuba.ac.jp – sequence: 3 givenname: Masahiko surname: Iwakiri fullname: Iwakiri, Masahiko – sequence: 4 givenname: Takashi surname: Asada fullname: Asada, Takashi |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18968235$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17521792$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kttu1DAQhiNURLeFJ0BCvgGB1Cw-5HjBxarlUKmIFYJry3EmZFaJndpOYXlRXgfvAZC46IVle_T94_H8c5acGGsgSZ4yumSUFa83y8lMzbTklJZLmi0pEw-SBavKKs04K06SBeXxnFdZcZqceb-hNCJUPEpOWZlzVtZ8kfy6HsfZ2B59sLqHEbUaiDItwX28GWyIVzVsPXpiO3JlJzWigT2jt3pATVYf16mDb_OgArRk6q2Pa3I2AJoL4iDG8Q7IaAfQEXJkVN4TwS9iQeTl1erzep0K_oqgIaEHMjnonDUhFqKtC_Bj966fmw3o4Ml3DD3xusefduodGFT7Uhqc7C51i966Ftzj5GGnBg9Pjvt58vXd2y-XH9KbT--vL1c3qRZVGdJaFzltVEYbmjNW6lZx3pYZ8IbqrhWsKoqCZXkNlW6FajLQQvAq64SqWcarWpwnLw55439vZ_BBjug1DIMyYGcvS1oWNFoSwWdHcG5GaOXkcFRuK_9YEYHnR0D5aELnlNHo_3FVXVRc5JGrD5x21vvYK6kxxA7HjjmFg2RU7sZDbuR-PORuPCTNZPQ-asV_2r_p71W9OaggNvIOwUmvEYyGFl30RLYW79X_Bm362DI |
| CODEN | PNPPD7 |
| CitedBy_id | crossref_primary_10_1016_j_pnpbp_2008_10_020 crossref_primary_10_1007_s12264_016_0088_8 crossref_primary_10_1016_j_neubiorev_2009_06_005 crossref_primary_10_1016_j_schres_2008_05_014 crossref_primary_10_1159_000481929 crossref_primary_10_1016_j_brainresbull_2011_12_001 crossref_primary_10_1002_ajmg_b_30707 crossref_primary_10_1016_j_pnpbp_2024_111060 crossref_primary_10_1007_s11064_007_9470_2 crossref_primary_10_1186_1477_5751_9_4 crossref_primary_10_3389_fcell_2023_919297 crossref_primary_10_3390_ijms24065945 crossref_primary_10_1016_j_pnpbp_2011_07_010 crossref_primary_10_1016_j_psychres_2015_08_026 crossref_primary_10_1016_j_jpain_2018_12_008 crossref_primary_10_1016_S1516_4446_12_70015_6 crossref_primary_10_1016_j_jchemneu_2010_09_004 crossref_primary_10_1016_j_pnpbp_2014_03_014 crossref_primary_10_1038_mp_2012_174 crossref_primary_10_1038_tp_2011_1 crossref_primary_10_1016_j_pnpbp_2011_03_016 crossref_primary_10_3390_biom13081220 crossref_primary_10_1016_j_jad_2015_07_014 crossref_primary_10_1080_14728222_2017_1279149 crossref_primary_10_1177_0269881114523864 crossref_primary_10_1007_s00795_010_0524_1 crossref_primary_10_1038_s41598_019_51456_7 crossref_primary_10_1038_tp_2016_261 crossref_primary_10_1016_j_neuropharm_2020_108047 crossref_primary_10_1515_rns_2011_012 crossref_primary_10_1007_s11064_008_9595_y crossref_primary_10_1007_s10571_010_9562_4 crossref_primary_10_1038_npp_2011_267 crossref_primary_10_3389_fncel_2019_00331 crossref_primary_10_1016_j_neuroscience_2015_12_028 crossref_primary_10_18632_oncotarget_17339 crossref_primary_10_1016_j_neuroscience_2016_07_022 crossref_primary_10_1016_j_neuropharm_2011_07_025 crossref_primary_10_1124_pr_110_002642 crossref_primary_10_3389_fnins_2022_989046 crossref_primary_10_1016_j_neuroimage_2011_08_036 crossref_primary_10_1111_j_1399_5618_2009_00717_x crossref_primary_10_1186_1744_9081_8_19 crossref_primary_10_1038_npp_2009_111 |
| Cites_doi | 10.1126/science.281.5378.838 10.1111/j.1471-4159.1992.tb08361.x 10.1038/sj.mp.4001547 10.1016/S0301-0082(02)00017-5 10.1001/archpsyc.59.8.705 10.1126/science.294.5544.1024 10.1111/j.1471-4159.1990.tb08839.x 10.1016/j.neulet.2005.04.025 10.1016/j.neures.2004.06.006 10.1002/syn.20292 10.1016/S0165-0173(99)00044-2 10.1176/ajp.154.4.1 10.1152/jn.2000.83.5.2996 10.1523/JNEUROSCI.4650-03.2004 |
| ContentType | Journal Article |
| Copyright | 2007 Elsevier Inc. 2007 INIST-CNRS |
| Copyright_xml | – notice: 2007 Elsevier Inc. – notice: 2007 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.pnpbp.2007.04.013 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1878-4216 |
| EndPage | 1181 |
| ExternalDocumentID | 17521792 18968235 10_1016_j_pnpbp_2007_04_013 S0278584607001406 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIMH NIH HHS grantid: MH/NS 31862 |
| GroupedDBID | --- --K --M .GJ .~1 0R~ 123 1B1 1RT 1~. 1~5 29P 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXLA AAXUO ABCQJ ABFRF ABIVO ABJNI ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMQ HMT HVGLF HZ~ IHE J1W KOM L7B M2V M34 M41 MO0 MOBAO N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SES SEW SNS SPT SSN SSP SSZ T5K TEORI WUQ ZGI ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH 08R AAPBV ABPIF ABPTK IQODW CGR CUY CVF ECM EFKBS EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c387t-9c650ba40b05117cda22d74e2b0cfd3186661459e8cd3ab4ec33284f3a9142893 |
| IEDL.DBID | AIKHN |
| ISSN | 0278-5846 |
| IngestDate | Fri Jul 11 04:36:53 EDT 2025 Mon Jul 21 05:33:45 EDT 2025 Sun Oct 22 16:04:59 EDT 2023 Tue Jul 01 01:50:06 EDT 2025 Thu Apr 24 23:10:04 EDT 2025 Fri Feb 23 02:32:22 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | AMPA AMP DLPFC Schizophrenia DARPP-32 Bipolar disorder AMP-regulated phosphoprotein Prefrontal cortex PMI PP1 CDK5 PP2B GABA NMDA Thr Mood disorder Human Immunohistochemistry Dopamine Central nervous system Cyclic AMP Catecholamine Encephalon Psychosis Neurotransmitter Immunoblotting assay |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c387t-9c650ba40b05117cda22d74e2b0cfd3186661459e8cd3ab4ec33284f3a9142893 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 17521792 |
| PQID | 70760878 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_70760878 pubmed_primary_17521792 pascalfrancis_primary_18968235 crossref_citationtrail_10_1016_j_pnpbp_2007_04_013 crossref_primary_10_1016_j_pnpbp_2007_04_013 elsevier_sciencedirect_doi_10_1016_j_pnpbp_2007_04_013 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2007-08-15 |
| PublicationDateYYYYMMDD | 2007-08-15 |
| PublicationDate_xml | – month: 08 year: 2007 text: 2007-08-15 day: 15 |
| PublicationDecade | 2000 |
| PublicationPlace | Amsterdam |
| PublicationPlace_xml | – name: Amsterdam – name: England |
| PublicationTitle | Progress in neuro-psychopharmacology & biological psychiatry |
| PublicationTitleAlternate | Prog Neuropsychopharmacol Biol Psychiatry |
| PublicationYear | 2007 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Emamian, Karayiorgou, Gogos (bib5) 2004; 24 Albert, Hemmings, Adamo, Potkin, Akbarian, Sandman (bib1) 2002; 59 Grebb, Girault, Ehrlich, Greengard (bib7) 1990; 55 Ogden, Rich, Schork, Paulus, Geyer, Lohr (bib14) 2004; 9 American Psychiatric Association (bib2) 1994 Baracskay, Haroutunian, Meador-Woodruff (bib4) 2006; 60 Fienberg, Hiroi, Mermelstein, Song, Snyder, Nishi (bib6) 1998; 281 Meador-Woodruff, Healy (bib13) 2000; 31 American Psychiatric Association (bib3) 1997; 154 Ishikawa, Mizukami, Iwakiri, Asada (bib10) 2005; 383 Ishikawa, Mizukami, Iwakiri, Hidak, Asada (bib11) 2004; 50 Jorge, Hernandez, Snyder, Yan, Fienberg, Moss (bib12) 2000; 83 Pralong, Magistretti, Stoop (bib15) 2002; 67 Greengard (bib8) 2001; 294 Guitart, Nestler (bib9) 1992; 59 American Psychiatric Association (10.1016/j.pnpbp.2007.04.013_bib2) 1994 Ishikawa (10.1016/j.pnpbp.2007.04.013_bib11) 2004; 50 Baracskay (10.1016/j.pnpbp.2007.04.013_bib4) 2006; 60 Emamian (10.1016/j.pnpbp.2007.04.013_bib5) 2004; 24 Meador-Woodruff (10.1016/j.pnpbp.2007.04.013_bib13) 2000; 31 Ogden (10.1016/j.pnpbp.2007.04.013_bib14) 2004; 9 Albert (10.1016/j.pnpbp.2007.04.013_bib1) 2002; 59 Guitart (10.1016/j.pnpbp.2007.04.013_bib9) 1992; 59 Jorge (10.1016/j.pnpbp.2007.04.013_bib12) 2000; 83 Ishikawa (10.1016/j.pnpbp.2007.04.013_bib10) 2005; 383 Fienberg (10.1016/j.pnpbp.2007.04.013_bib6) 1998; 281 Grebb (10.1016/j.pnpbp.2007.04.013_bib7) 1990; 55 Greengard (10.1016/j.pnpbp.2007.04.013_bib8) 2001; 294 Pralong (10.1016/j.pnpbp.2007.04.013_bib15) 2002; 67 American Psychiatric Association (10.1016/j.pnpbp.2007.04.013_bib3) 1997; 154 |
| References_xml | – volume: 24 start-page: 1561 year: 2004 end-page: 1564 ident: bib5 article-title: Decreased phosphorylation of NMDA receptor 1 at serine 897 in brains of patients with schizophrenia publication-title: J Neurosci – volume: 60 start-page: 271 year: 2006 end-page: 279 ident: bib4 article-title: Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex publication-title: Synapse – volume: 83 start-page: 2996 year: 2000 end-page: 3004 ident: bib12 article-title: D1 dopamine receptor activation reduces GABAA receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade publication-title: J Neurophysiol – volume: 59 start-page: 705 year: 2002 end-page: 712 ident: bib1 article-title: Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia publication-title: Arch Gen Psychiatry – volume: 31 start-page: 288 year: 2000 end-page: 294 ident: bib13 article-title: Glutamate receptor expression in schizophrenic brain publication-title: Brain Res Brain Res Rev – volume: 50 start-page: 77 year: 2004 end-page: 84 ident: bib11 article-title: Immunohistochemical and immunoblot study of GABAA α1 and β2/3 subunits in the prefrontal cortex of subjects with schizophrenia and bipolar disorder publication-title: Neurosci Res – volume: 281 start-page: 838 year: 1998 end-page: 842 ident: bib6 article-title: DARPP-32: regulator of the efficacy of dopaminergic neurotransmission publication-title: Science – volume: 67 start-page: 173 year: 2002 end-page: 202 ident: bib15 article-title: Cellular perspectives on the glutamate-monoamine interactions in limbic lobe structures and their relevance for some psychiatric disorders publication-title: Prog Neurobiol – volume: 154 start-page: 1 year: 1997 end-page: 63 ident: bib3 article-title: Practical guideline for the treatment of patients with schizophrenia publication-title: Am J Psychiatry – volume: 294 start-page: 1024 year: 2001 end-page: 1030 ident: bib8 article-title: The neurobiology of slow synaptic transmission publication-title: Science – volume: 9 start-page: 1007 year: 2004 end-page: 1029 ident: bib14 article-title: Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach publication-title: Mol Psychiatry – volume: 59 start-page: 1164 year: 1992 end-page: 1167 ident: bib9 article-title: Chronic administration of lithium or other antidepressants increases levels of DARPP-32 in rat frontal cortex publication-title: J Neurochem – year: 1994 ident: bib2 article-title: Diagnostic and Statistical Manual of Mental Disorders – volume: 383 start-page: 272 year: 2005 end-page: 277 ident: bib10 article-title: Immunohistochemical and immunoblot analysis of gamma-aminobutyric acid B receptor in the prefrontal cortex of subjects with schizophrenia and bipolar disorder publication-title: Neurosci Lett – volume: 55 start-page: 204 year: 1990 end-page: 207 ident: bib7 article-title: Chronic treatment of rats with SCH-23390 or raclopride does not affect the concentrations of DARPP-32 or its mRNA in dopamine-innervated brain regions publication-title: J Neurochem – volume: 281 start-page: 838 year: 1998 ident: 10.1016/j.pnpbp.2007.04.013_bib6 article-title: DARPP-32: regulator of the efficacy of dopaminergic neurotransmission publication-title: Science doi: 10.1126/science.281.5378.838 – volume: 59 start-page: 1164 year: 1992 ident: 10.1016/j.pnpbp.2007.04.013_bib9 article-title: Chronic administration of lithium or other antidepressants increases levels of DARPP-32 in rat frontal cortex publication-title: J Neurochem doi: 10.1111/j.1471-4159.1992.tb08361.x – volume: 9 start-page: 1007 year: 2004 ident: 10.1016/j.pnpbp.2007.04.013_bib14 article-title: Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001547 – volume: 67 start-page: 173 year: 2002 ident: 10.1016/j.pnpbp.2007.04.013_bib15 article-title: Cellular perspectives on the glutamate-monoamine interactions in limbic lobe structures and their relevance for some psychiatric disorders publication-title: Prog Neurobiol doi: 10.1016/S0301-0082(02)00017-5 – volume: 59 start-page: 705 year: 2002 ident: 10.1016/j.pnpbp.2007.04.013_bib1 article-title: Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.59.8.705 – volume: 294 start-page: 1024 year: 2001 ident: 10.1016/j.pnpbp.2007.04.013_bib8 article-title: The neurobiology of slow synaptic transmission publication-title: Science doi: 10.1126/science.294.5544.1024 – volume: 55 start-page: 204 year: 1990 ident: 10.1016/j.pnpbp.2007.04.013_bib7 article-title: Chronic treatment of rats with SCH-23390 or raclopride does not affect the concentrations of DARPP-32 or its mRNA in dopamine-innervated brain regions publication-title: J Neurochem doi: 10.1111/j.1471-4159.1990.tb08839.x – volume: 383 start-page: 272 year: 2005 ident: 10.1016/j.pnpbp.2007.04.013_bib10 article-title: Immunohistochemical and immunoblot analysis of gamma-aminobutyric acid B receptor in the prefrontal cortex of subjects with schizophrenia and bipolar disorder publication-title: Neurosci Lett doi: 10.1016/j.neulet.2005.04.025 – volume: 50 start-page: 77 year: 2004 ident: 10.1016/j.pnpbp.2007.04.013_bib11 article-title: Immunohistochemical and immunoblot study of GABAA α1 and β2/3 subunits in the prefrontal cortex of subjects with schizophrenia and bipolar disorder publication-title: Neurosci Res doi: 10.1016/j.neures.2004.06.006 – volume: 60 start-page: 271 year: 2006 ident: 10.1016/j.pnpbp.2007.04.013_bib4 article-title: Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex publication-title: Synapse doi: 10.1002/syn.20292 – volume: 31 start-page: 288 year: 2000 ident: 10.1016/j.pnpbp.2007.04.013_bib13 article-title: Glutamate receptor expression in schizophrenic brain publication-title: Brain Res Brain Res Rev doi: 10.1016/S0165-0173(99)00044-2 – year: 1994 ident: 10.1016/j.pnpbp.2007.04.013_bib2 – volume: 154 start-page: 1 year: 1997 ident: 10.1016/j.pnpbp.2007.04.013_bib3 article-title: Practical guideline for the treatment of patients with schizophrenia publication-title: Am J Psychiatry doi: 10.1176/ajp.154.4.1 – volume: 83 start-page: 2996 year: 2000 ident: 10.1016/j.pnpbp.2007.04.013_bib12 article-title: D1 dopamine receptor activation reduces GABAA receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade publication-title: J Neurophysiol doi: 10.1152/jn.2000.83.5.2996 – volume: 24 start-page: 1561 year: 2004 ident: 10.1016/j.pnpbp.2007.04.013_bib5 article-title: Decreased phosphorylation of NMDA receptor 1 at serine 897 in brains of patients with schizophrenia publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4650-03.2004 |
| SSID | ssj0001303 |
| Score | 2.0672743 |
| Snippet | Dopamine and cyclic adenosine 3′:5′-monophosphate (AMP)-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32), plays an important role in... Dopamine and cyclic adenosine 3':5'-monophosphate (AMP)-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32), plays an important role in... |
| SourceID | proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1177 |
| SubjectTerms | Adult Adult and adolescent clinical studies Aged Aged, 80 and over Biological and medical sciences Bipolar disorder Bipolar Disorder - metabolism Bipolar Disorder - pathology Bipolar disorders Blotting, Western - methods DARPP-32 Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism Female Humans Immunohistochemistry - methods Male Medical sciences Middle Aged Mood disorders Neuropharmacology Pharmacology. Drug treatments Postmortem Changes Prefrontal cortex Prefrontal Cortex - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - metabolism Schizophrenia - pathology |
| Title | Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder |
| URI | https://dx.doi.org/10.1016/j.pnpbp.2007.04.013 https://www.ncbi.nlm.nih.gov/pubmed/17521792 https://www.proquest.com/docview/70760878 |
| Volume | 31 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb5wwELbyuFSqqr67TbudQxW10pIFGzAcV0mjTatEqzaRckPGGIVqF1DYjbqX_s3-nc4YyDaH5NADB4wtLDPMfB7PfMPYR6rmoHicO0px4_jaE04UpLkTKMQKaNGVjCjB-fQsnF74Xy-Dyy122OfCUFhlp_tbnW61ddcy7lZzXBfF-AedmZH5dKUliQm32S4XcYiivTs5-TY9u1XIpKatq0VSkpEf9uRDNsyrLuu07qgM_QPXE_cZqMe1anDZ8rbexf2A1Bqm46fsSYcoYdJO-hnbMuVztj9rKanXIzjfZFg1I9iH2Yasev2C_TmhBJHK0g7rjjwAVJlBYdvTebXE25a4BKocjnCTvUBkavvotZ4XGianM-e6rWlvMqivqgYvSwBRlCNos2VuDCz6SrywQMQOgo9w1eDT0eT7bOYI_hmKEhCOQo1rQrQKOBFNocC_6L3NKiWPUQPkOIbm31BBO5W0qGmTDlnHJvqSXRx_OT-cOl2xB0eLSC6dWCNWTJXvpqgmPKkzxXkmfcNTV-eZIF4-RBJBbCKdCZX6RguBpjUXKibSuFi8YjtlVZo3DHLlKZ4rX-k88vFhTJxvnvE0HYNmsRww3n_hRHdM6FSQY570IW8_EysWVKNTJq6foFgM2Oh2UN0SgTzcPexFJ7kjzwmaqocHDu8I2uZlURxGXAQD9qGXvARVAZ3vqNJUqyaRdMoayWjAXrcCuRkrEaXJmL_931ntsUetUztyvOAd21ler8x7RGPLdMi2D357w-6f-wtK4jeC |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLfGOICEEN-Uj-0d0ARSsza2UyfHamPqYJ0q6KTdIsdxRFCbREuL6IV_k3-H95yEssN24JBDHFu2nOf3frbf-z3G3lE2B82jzNOaW08aX3hhkGReoBEroEXXKqQA5-n5aHIhP10GlzvsqIuFIbfKVvc3Ot1p67Zk0M7moMrzwVe6MyPzOVSOJGZ0h92VuHxpdR7-2vp5kJJ2By2KQozkqKMeck5eVVElVUtkKA-HvrjJPD2odI2TljXZLm6Go84snTxiD1s8CeNmyI_Zji2esINZQ0i96cN8G19V9-EAZluq6s1T9vuUwkNKRzpsWuoA0EUKuStPFuUKXxvaEigzOMYt9hJxqatjNmaRGxhPZ95Vk9HeplB9K2t8HP1DXvShiZX5YWHZ5eGFJeJ1ELyPswbvj8dfZjNP8A-QF4BgFCqcEyJVwIEYcgT-Sf3W64TOi2qgY2Oo_3UUdENJ8oq26JC2XKLP2MXJx_nRxGtTPXhGhGrlRQaRYqLlMEEl4SuTas5TJS1PhiZLBbHyIY4IIhuaVOhEWiMEGtZM6Igo4yLxnO0WZWFfMsi0r3mmpTZZKPFjRIxvvvUNXYKmkeox3v3h2LQ86JSOYxF3Dm_fYycWlKFTxUMZo1j0WP9vo6qhAbm9-qgTnfiaNMdoqG5vuHdN0LadhdEo5CLosf1O8mJUBHS7owtbrutY0R1rqMIee9EI5LatQoymIv7qf0e1z-5N5tOz-Oz0_PNrdr853g49P3jDdldXa_sWcdkq2XPr7g_jszhG |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunohistochemical+and+immunoblot+analysis+of+Dopamine+and+cyclic+AMP-regulated+phosphoprotein%2C+relative+molecular+mass+32%2C000+%28DARPP-32%29+in+the+prefrontal+cortex+of+subjects+with+schizophrenia+and+bipolar+disorder&rft.jtitle=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.au=Ishikawa%2C+Masanori&rft.au=Mizukami%2C+Katsuyoshi&rft.au=Iwakiri%2C+Masahiko&rft.au=Asada%2C+Takashi&rft.date=2007-08-15&rft.issn=0278-5846&rft.volume=31&rft.issue=6&rft.spage=1177&rft_id=info:doi/10.1016%2Fj.pnpbp.2007.04.013&rft_id=info%3Apmid%2F17521792&rft.externalDocID=17521792 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0278-5846&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0278-5846&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0278-5846&client=summon |