Evolutionary dynamics of Enterococcus faecium reveals complex genomic relationships between isolates with independent emergence of vancomycin resistance

• Published in: Microbial genomics Vol. 2; no. 1
• Main Authors: van Hal, Sebastiaan J., Ip, Camilla L. C., Ansari, M. Azim, Wilson, Daniel J., Espedido, Bjorn A., Jensen, Slade O., Bowden, Rory
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 19.01.2016
• Subjects: Bacterial Typing Techniques; Enterococcus faecium - genetics; Enterococcus faecium - isolation & purification; Evolution, Molecular; Genome, Bacterial - genetics; Multilocus Sequence Typing; Phylogeny; Species Specificity; Vancomycin Resistance - genetics; transposon; Enterococcus faecium; multi-locus sequence typing; infection control; recombination; vancomycin resistance

, a major cause of hospital-acquired infections, remains problematic because of its propensity to acquire resistance to vancomycin, which currently is considered first-line therapy. Here, we assess the evolution and resistance acquisition dynamics of in a clinical context using a series of 132 blood...