Lyme Disease Pathogenesis

• Published in: Current Issues in Molecular Biology Vol. 42; pp. 473 - 518
• Main Authors: Coburn, Jenifer, Garcia, Brandon, Hu, Linden T., Jewett, Mollie W., Kraiczy, Peter, Norris, Steven J., Skare, Jon
• Format: Journal Article
• Language: English
• Published: Switzerland 2021
• Subjects: Animals; Arthropod Vectors - microbiology; Borrelia - genetics; Disease Models, Animal; Disease Susceptibility; Gene Expression Regulation, Bacterial; Host-Pathogen Interactions; Humans; Lyme Disease - microbiology; Lyme Disease - transmission; Ticks - microbiology; Virulence; Virulence Factors - genetics

Lyme disease are obligately parasitic, tick- transmitted, invasive, persistent bacterial pathogens that cause disease in humans and non-reservoir vertebrates primarily through the induction of inflammation. During transmission from the infected tick, the bacteria undergo significant changes in gene...