Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum

• Published in: Cell chemical biology Vol. 26; no. 4; pp. 571 - 583.e6
• Main Authors: Gamayun, Igor, O'Keefe, Sarah, Pick, Tillman, Klein, Marie-Christine, Nguyen, Duy, McKibbin, Craig, Piacenti, Michela, Williams, Helen M., Flitsch, Sabine L., Whitehead, Roger C., Swanton, Eileithyia, Helms, Volkhard, High, Stephen, Zimmermann, Richard, Cavalié, Adolfo
• Format: Journal Article
• Language: English
• Published: Cell Press 18.04.2019

Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport within the endomembrane system. Here, we show that ES1 impairs Ca 2+ homeostasis by enhancing the Ca 2+ leakage from mammalian ER. A com...