Chronic Hyperglycemia before Spinal Cord Injury Increases Inflammatory Reaction and Astrogliosis after Injury: Human and Rat Studies

• Published in: Journal of neurotrauma Vol. 37; no. 9; pp. 1165 - 1181
• Main Authors: Park, Ki-Su, Kim, Jin Bum, Keung, Martin, Seo, Ye Jin, Seo, Sung Young, Mun, Seul Ah, Lee, Young-Seok, Cho, Dae-Chul, Hwang, Jeong-Hyun, Han, Inbo, Kim, Chi Heon, Kim, Kyoung-Tae
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.05.2020
• Subjects: Aneurysms; Cerebrospinal fluid; Diabetes; Free radicals; Gliosis; Glucose; Hemoglobin; Hospitals; Hyperglycemia; Inflammation; Insulin; Interleukin 8; Laboratories; Magnetic resonance imaging; Quality of life; Recovery of function; Risk factors; Spinal cord injuries; Trauma; Minneapolis Minnesota; United States > US; Germany; SCI; hyperglycemia; gliosis; inflammation

Traumatic spinal cord injury (SCI) can cause permanent disabilities that seriously reduce quality of life. We evaluated the effects of chronic hyperglycemia before SCI on inflammatory markers and functional recovery after SCI in human patients and a rat model. In the human study, multivariate logist...