Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion

• Published in: The Journal of neuroscience Vol. 43; no. 9; pp. 1475 - 1491
• Main Authors: Seibert, Michael J, Evans, Chantell S, Stanley, Kevin S, Wu, Zhenyong, Chapman, Edwin R
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 01.03.2023
• Subjects: Animals; Brain; Calcium; Calcium - metabolism; Calcium ions; Dense core vesicles; Exocytosis; Hippocampus; Membrane fusion; Mice; Mutation; Neostriatum; Neuromodulation; Neurons; Neurons - metabolism; Neurotransmitter Agents - metabolism; Neurotransmitter release; Neurotransmitters; Sensors; Substance P; Substance P - metabolism; Synaptic transmission; Synaptic Transmission - physiology; Synaptic Vesicles - metabolism; Synaptotagmin; Synaptotagmin I - metabolism; Synaptotagmins - metabolism; neuromodulation; exocytosis; synaptic transmission; synaptotagmin; spontaneous neurotransmitter release; neuropeptide

Synaptotagmin 9 (SYT9) is a tandem C2 domain Ca sensor for exocytosis in neuroendocrine cells; its function in neurons remains unclear. Here, we show that, in mixed-sex cultures, SYT9 does not trigger rapid synaptic vesicle exocytosis in mouse cortical, hippocampal, or striatal neurons, unless it is...