Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats

• Published in: Toxicological sciences Vol. 140; no. 2; pp. 374 - 392
• Main Authors: Ferguson, Sherry A., Law, Charles Delbert, Kissling, Grace E.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.08.2014
• Subjects: Animals; Behavior, Animal - drug effects; Benzhydryl Compounds - toxicity; Body Weight - drug effects; Drinking Behavior - drug effects; Endocrine Disruptors - toxicity; Ethinyl Estradiol - toxicity; Feeding Behavior - drug effects; Female; Humans; Male; Neurotoxicology; Organ Size - drug effects; Phenols - toxicity; Rats, Sprague-Dawley; Sex Characteristics; Sexual Maturation - drug effects; developmental; bisphenol A; estrous cycle; puberty; behavior; ethinyl estradiol

The developing central nervous system may be particularly sensitive to bisphenol A (BPA)-induced alterations. Here, pregnant Sprague Dawley rats (n = 11-12/group) were gavaged daily with vehicle, 2.5 or 25.0 μg/kg BPA, or 5.0 or 10.0 μg/kg ethinyl estradiol (EE2) on gestational days 6-21. The BPA do...