Integrated miRNA and mRNA expression profiling in response to eriodictyol in human endothelial cells
Eriodictyol, a flavonoid commonly found in citrus fruits, shows neurotrophic, antioxidant, anti- inflammatory, and anti-cancer effects under diverse pathophysiological conditions such as vascular diseases. In this study, we evaluated whether eriodictyol modulates miRNA and mRNA expression. Using mic...
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| Published in | Biochip journal Vol. 11; no. 3; pp. 188 - 195 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
The Korean BioChip Society (KBCS)
01.09.2017
Springer Nature B.V 한국바이오칩학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1976-0280 2092-7843 |
| DOI | 10.1007/s13206-017-1303-z |
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| Abstract | Eriodictyol, a flavonoid commonly found in citrus fruits, shows neurotrophic, antioxidant, anti- inflammatory, and anti-cancer effects under diverse pathophysiological conditions such as vascular diseases. In this study, we evaluated whether eriodictyol modulates miRNA and mRNA expression. Using microarray analysis, we examined miRNA and mRNA expression in human endothelial cells treated with 10 μM of eriodictyol for 24 h. Using numerous bioinformatic systems, we evaluated the signatures of the potential biological processes and signaling pathways. Our results provide insight into the underlying molecular mechanisms of action of eriodictyol and suggest that eriodictyol can be used for therapeutic intervention in vascular disease. |
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| AbstractList | Eriodictyol, a flavonoid commonly found in citrus fruits, shows neurotrophic, antioxidant, anti- inflammatory, and anti-cancer effects under diverse pathophysiological conditions such as vascular diseases. In this study, we evaluated whether eriodictyol modulates miRNA and mRNA expression. Using microarray analysis, we examined miRNA and mRNA expression in human endothelial cells treated with 10 μM of eriodictyol for 24 h. Using numerous bioinformatic systems, we evaluated the signatures of the potential biological processes and signaling pathways. Our results provide insight into the underlying molecular mechanisms of action of eriodictyol and suggest that eriodictyol can be used for therapeutic intervention in vascular disease. Eriodictyol, a flavonoid commonly found in citrus fruits, shows neurotrophic, antioxidant, anti- inflammatory, and anti-cancer effects under diverse pathophysiological conditions such as vascular diseases. In this study, we evaluated whether eriodictyol modulates miRNA and mRNA expression. Using microarray analysis, we examined miRNA and mRNA expression in human endothelial cells treated with 10 μM of eriodictyol for 24 h. Using numerous bioinformatic systems, we evaluated the signatures of the potential biological processes and signaling pathways. Our results provide insight into the underlying molecular mechanisms of action of eriodictyol and suggest that eriodictyol can be used for therapeutic intervention in vascular disease. KCI Citation Count: 7 |
| Author | Park, Hye Rim Ahn, Hyun-Jong Park, Cheung-Seog Park, Yong Seek Lee, Seung Eun Yun, Hong Duck Cho, Jeong-Je |
| Author_xml | – sequence: 1 givenname: Seung Eun surname: Lee fullname: Lee, Seung Eun organization: Department of Microbiology, School of Medicine, Kyung Hee University – sequence: 2 givenname: Hye Rim surname: Park fullname: Park, Hye Rim organization: Department of Biomedical Science, Graduate School, Kyung Hee University – sequence: 3 givenname: Hong Duck surname: Yun fullname: Yun, Hong Duck organization: Department of Biomedical Science, Graduate School, Kyung Hee University – sequence: 4 givenname: Jeong-Je surname: Cho fullname: Cho, Jeong-Je organization: Department of Microbiology, School of Medicine, Kyung Hee University – sequence: 5 givenname: Hyun-Jong surname: Ahn fullname: Ahn, Hyun-Jong organization: Department of Microbiology, School of Medicine, Kyung Hee University – sequence: 6 givenname: Cheung-Seog surname: Park fullname: Park, Cheung-Seog organization: Department of Microbiology, School of Medicine, Kyung Hee University – sequence: 7 givenname: Yong Seek surname: Park fullname: Park, Yong Seek email: yongseek@khu.ac.kr organization: Department of Microbiology, School of Medicine, Kyung Hee University |
| BackLink | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002262990$$DAccess content in National Research Foundation of Korea (NRF) |
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| CitedBy_id | crossref_primary_10_3390_nu16234237 crossref_primary_10_1039_C8AN01739E crossref_primary_10_1038_s41427_019_0184_0 crossref_primary_10_1016_j_jpba_2023_115266 crossref_primary_10_1039_C9LC00958B crossref_primary_10_1007_s12257_020_0002_0 crossref_primary_10_1021_acs_jafc_8b03865 crossref_primary_10_2147_DDDT_S239662 crossref_primary_10_1007_s13206_018_2201_8 |
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| Keywords | miRNA Vascular diseases Flavonoid Endothelial cells Eriodictyol |
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| SubjectTerms | Anticancer properties Antioxidants Biological activity Biomedical Engineering and Bioengineering Biotechnology Chemistry Chemistry and Materials Science Citrus fruits Disease Endothelial cells Flavonoids Gene expression Genomes Inflammation MicroRNAs miRNA Molecular modelling Original Article Vascular diseases 생물공학 |
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